Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Mads Kærn"'
Autor:
Hertek Gill, Mahdi Ahsan, Yara Khalil, Victoria Feng, Jessie Pearce, Tarasha Sharma, Mohamad Radwan, Austin Boucinha, Mads Kærn
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 10 (2022)
Post-secondary education is falling behind in delivering the talent and skills development needed to support the growth of biology-based economies and the demands of professional and research-based graduate degree programs. Here, we describe an appli
Externí odkaz:
https://doaj.org/article/45b33becd9a2426482d2b0c4c48fd0e7
Publikováno v:
BMC Genomics, Vol 20, Iss 1, Pp 1-19 (2019)
Abstract Background Phenotypic variability of human populations is partly the result of gene polymorphism and differential gene expression. As such, understanding the molecular basis for diversity requires identifying genes with both high and low pop
Externí odkaz:
https://doaj.org/article/8008a172817b473b886a6e0d248fbe65
Autor:
Louis Dacquay, Annika Flint, James Butcher, Danny Salem, Michael Kennedy, Mads Kaern, Alain Stintzi, Kristin Baetz
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 7, Iss 6, Pp 1799-1809 (2017)
Actively proliferating cells constantly monitor and readjust their metabolic pathways to ensure the replenishment of phospholipids necessary for membrane biogenesis and intracellular trafficking. In Saccharomyces cerevisiae, multiple studies have sug
Externí odkaz:
https://doaj.org/article/0f1be6d03df244588a4133165f36ffd7
Publikováno v:
Engineering Biology (2019)
Drug resistance complicates the treatment of cancer and infectious diseases, and often arises from the elevated expression of a gene that neutralises or reduces drug activity. To investigate this and other expression-based mechanisms of drug resistan
Externí odkaz:
https://doaj.org/article/fed4bb08befb47b78cd2cede2470ea17
Publikováno v:
Applied Sciences, Vol 11, Iss 6, p 2692 (2021)
Accurate and efficient segmentation of live-cell images is critical in maximizing data extraction and knowledge generation from high-throughput biology experiments. Despite recent development of deep-learning tools for biomedical imaging applications
Externí odkaz:
https://doaj.org/article/5fda3203387a4eebbf1ff2b106ac29b8
Publikováno v:
Cell Reports, Vol 5, Iss 4, Pp 961-973 (2013)
The subgranular zone (SGZ) of the adult hippocampus contains a pool of quiescent neural progenitor cells (QNPs) that are capable of entering the cell cycle and producing newborn neurons. The mechanisms that control the timing and extent of adult neur
Externí odkaz:
https://doaj.org/article/57a2ee747e974ea4b10e793eb5c85ca9
Autor:
Hilary Phenix, Katy Morin, Cory Batenchuk, Jacob Parker, Vida Abedi, Liu Yang, Lioudmila Tepliakova, Theodore J Perkins, Mads Kærn
Publikováno v:
PLoS Computational Biology, Vol 7, Iss 5, p e1002048 (2011)
Inferring regulatory and metabolic network models from quantitative genetic interaction data remains a major challenge in systems biology. Here, we present a novel quantitative model for interpreting epistasis within pathways responding to an externa
Externí odkaz:
https://doaj.org/article/44582b5da47d4f9b8a6daa90782662e7
Autor:
Carl Song, Hilary Phenix, Vida Abedi, Matthew Scott, Brian P. Ingalls, Mads Kærn, Theodore J. Perkins
Publikováno v:
PLoS Computational Biology, Vol 6, Iss 3 (2010)
Externí odkaz:
https://doaj.org/article/b6db0884543941d29a0acb72e43fe464
Autor:
Carl Song, Hilary Phenix, Vida Abedi, Matthew Scott, Brian P Ingalls, Mads Kaern, Theodore J Perkins
Publikováno v:
PLoS Computational Biology, Vol 6, Iss 3, p e1000699 (2010)
High throughput measurement of gene expression at single-cell resolution, combined with systematic perturbation of environmental or cellular variables, provides information that can be used to generate novel insight into the properties of gene regula
Externí odkaz:
https://doaj.org/article/71a9497a21404f98a96345c4045853f0
Publikováno v:
PLoS ONE, Vol 3, Iss 8, p e2956 (2008)
Caspase proteases are a conserved protein family predominantly known for engaging and executing apoptotic cell death. Nevertheless, in higher eukaryotes, caspases also influence a variety of cell behaviors including differentiation, proliferation and
Externí odkaz:
https://doaj.org/article/38a64e8a8597407e95bc1d33b08231a9