Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Mads Holger Rønnest"'
Publikováno v:
Petersen, A B, Rønnest, M H, Larsen, T O & Clausen, M H 2014, ' The Chemistry of Griseofulvin ', Chemical Reviews, vol. 114, no. 24, pp. 12088-12107 . https://doi.org/10.1021/cr400368e
Specific synthetic routes are presented in schemes to illustrate the chemistry, and the analogs are presented in a table format to give an accessible overview of the structures. Several patents have been published regarding the properties of griseofu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61afa7eb4e18a9e5e5a1a7b08f42d7d0
https://doi.org/10.1021/cr400368e
https://doi.org/10.1021/cr400368e
Identification of Griseofulvin as an Inhibitor of Centrosomal Clustering in a Phenotype-Based Screen
Autor:
Alwin Krämer, Blanka Rebacz, Thomas Ostenfeld Larsen, Mads Hartvig Clausen, Anthony D. Ho, Mads Holger Rønnest, Harald Löffler
Publikováno v:
Cancer Research. 67:6342-6350
A major drawback of cancer chemotherapy is the lack of tumor-specific targets which would allow for the selective eradication of malignant cells without affecting healthy tissues. In contrast with normal cells, most tumor cells contain multiple centr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adafddc6a439ff4c982e6610e801401f
https://doi.org/10.1158/0008-5472.can-07-0663
https://doi.org/10.1158/0008-5472.can-07-0663
Autor:
Simon Anderhub, Gleb Konotop, Anthony D. Ho, Johannes Fruehauf, Klaus Podar, Ludmila Weiz, Mads Hartvig Clausen, Iris Breitkreutz, Hartmut Goldschmidt, Kenneth C. Anderson, Uwe Haberkorn, Walter Mier, Mads Holger Rønnest, Alwin Krämer, Felix Nissen, Patrick Hayden, Marc S. Raab, Blanka Leber, Thomas Ostenfeld Larsen
Publikováno v:
Cancer research. 72(20)
In contrast to normal cells, malignant cells are frequently aneuploid and contain multiple centrosomes. To allow for bipolar mitotic division, supernumerary centrosomes are clustered into two functional spindle poles in many cancer cells. Recently, w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf73b8cfbda76430fa8203443e484d26
https://pubmed.ncbi.nlm.nih.gov/22942257
https://pubmed.ncbi.nlm.nih.gov/22942257
Autor:
Sven Boesen, Simon Anderhub, Thomas Ostenfeld Larsen, Mads Hartvig Clausen, Marc S. Raab, Alwin Krämer, Mads Holger Rønnest
Publikováno v:
Rønnest, M H, Raab, M S, Anderhub, S, Boesen, S, Krämer, A, Larsen, T O & Clausen, M H 2012, ' Disparate SAR Data of Griseofulvin Analogues for the Dermatophytes Trichophyton mentagrophytes, T. rubrum, and MDA-MB-231 Cancer Cells ', Journal of Medicinal Chemistry, vol. 55, no. 2, pp. 652-660 . https://doi.org/10.1021/jm200835c
Griseofulvin and 53 analogues of this compound have been tested against the pathogenic dermatophytes Trichophyton rubrum and Trichophyton mentagrophytes as well as against the breast cancer cell line MDA-MB-231. The modifications to griseofulvin incl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::486e2a7569d483c25be9bbe1ffa2d66c
https://orbit.dtu.dk/en/publications/cfadfe8d-afd0-45d7-9df3-4ced51914cd2
https://orbit.dtu.dk/en/publications/cfadfe8d-afd0-45d7-9df3-4ced51914cd2
Autor:
Morten Thrane Nielsen, Thomas Ostenfeld Larsen, Mads Hartvig Clausen, Blanka Leber, Mads Holger Rønnest, Uffe Hasbro Mortensen, Alwin Krämer, Pernille Harris
Publikováno v:
Rønnest, M H, Nielsen, M T, Leber, B, Mortensen, U H, Krämer, A, Clausen, M H, Larsen, T O & Harris, P 2011, ' (+)-Geodin from Aspergillus terreus. ', Acta Crystallographica. Section C: Crystal Structure Communications, vol. 67, no. Pt 3, pp. o125-o128 . https://doi.org/10.1107/S0108270111005816
The fungal metabolite (+)-geodin [systematic name: (2R)-methyl 5,7-dichloro-4-hydroxy-6'-methoxy-6-methyl-3,4'-dioxospiro[benzofuran-2,1'-cyclohexa-2',5'-diene]-2'-carboxylate], C(17)H(12)Cl(2)O(7), was isolated from Aspergillus terreus. The crystal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::498f01bcf722b896def51bc66a9a3476
https://pubmed.ncbi.nlm.nih.gov/21368412
https://pubmed.ncbi.nlm.nih.gov/21368412
Autor:
Anette Hinsch Terp, Lene Markworth, Blanka Rebacz, Mads Holger Rønnest, Mads Hartvig Clausen, Thomas Ostenfeld Larsen, Alwin Krämer
Publikováno v:
Journal of medicinal chemistry. 52(10)
Griseofulvin was identified as an inhibitor of centrosomal clustering in a recently developed assay. Centrosomal clustering is an important cellular event that enables bipolar mitosis for cancer cell lines harboring supernumerary centrosomes. We repo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31ad75f8bf1c1fc4fa526cc7be834bfd
https://pubmed.ncbi.nlm.nih.gov/19402668
https://pubmed.ncbi.nlm.nih.gov/19402668
Autor:
Charlotte Held Gotfredsen, Thomas Ostenfeld Larsen, Mads Holger Rønnest, Mads Hartvig Clausen, Pernille Harris
Publikováno v:
Tetrahedron Letters. 51:5881-5882
The two phenols, 6-O-desmethyl griseofulvin and 4-O-desmethyl griseofulvin are metabolites of the antifungal drug griseofulvin. Herein, we present an improved synthesis of the 6-phenol derivative, and an unequivocal proof of both structures by single
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eb5ee218f75d069fd332d14dfc26d3ee
https://doi.org/10.1016/j.tetlet.2010.08.095
https://doi.org/10.1016/j.tetlet.2010.08.095
Autor:
Kasper Worm, Mads Holger Rønnest, Blanka Rebacz, Thomas Ostenfeld Larsen, Alwin Krämer, Mads Hartvig Clausen
Publikováno v:
Technical University of Denmark Orbit
CIÊNCIAVITAE
CIÊNCIAVITAE
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::0dfe97b5f1265c781e35054943a6035d
https://orbit.dtu.dk/en/publications/a520e735-c69b-4b57-a464-fc8a899e55e9
https://orbit.dtu.dk/en/publications/a520e735-c69b-4b57-a464-fc8a899e55e9