Zobrazeno 1 - 10
of 148
pro vyhledávání: '"Mads Hartvig Clausen"'
Autor:
Zhijie Yang, Yijun Qiao, Emil Strøbech, Jens Preben Morth, Grit Walther, Tue Sparholt Jørgensen, Kah Yean Lum, Gundela Peschel, Miriam A. Rosenbaum, Viola Previtali, Mads Hartvig Clausen, Marie Vestergaard Lukassen, Charlotte Held Gotfredsen, Oliver Kurzai, Tilmann Weber, Ling Ding
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract Fungal infections pose a great threat to public health and there are only four main types of antifungal drugs, which are often limited with toxicity, drug-drug interactions and antibiotic resistance. Streptomyces is an important source of an
Externí odkaz:
https://doaj.org/article/66b2159e873649b59f7476838a72b699
Autor:
Sebastian J. Muderspach, Folmer Fredslund, Verena Volf, Jens-Christian Navarro Poulsen, Thomas H. Blicher, Mads Hartvig Clausen, Kim Krighaar Rasmussen, Kristian B. R. M. Krogh, Kenneth Jensen, Leila Lo Leggio
Publikováno v:
Biotechnology for Biofuels, Vol 14, Iss 1, Pp 1-16 (2021)
Abstract Background Endo-β-1,4-galactanases are glycoside hydrolases (GH) from the GH53 family belonging to the largest clan of GHs, clan GH-A. GHs are ubiquitous and involved in a myriad of biological functions as well as being widely used industri
Externí odkaz:
https://doaj.org/article/1a7bd7f27616404d8c9ce8214bb41518
Autor:
Viola Previtali, Ulrik Bering Keiding, Asger Hegelund Olsen, Jorge Peiró Cadahía, Anne Skovsbo Clausen, Andreas Kjaer, Thomas Lars Andresen, Anders Elias Hansen, Mads Hartvig Clausen
Publikováno v:
European Journal of Medicinal Chemistry Reports, Vol 4, Iss , Pp 100019- (2022)
Tofacitinib (CP-690,550), an approved Janus kinase (JAK) inhibitor, has been proven highly efficacious in treating rheumatoid arthritis (RA). Unfortunately, tofacitinib's clinical application has been limited by adverse side effects that arise from i
Externí odkaz:
https://doaj.org/article/287cda2a79ce492082e2d346cf4a50cb
Publikováno v:
Molecules, Vol 25, Iss 20, p 4664 (2020)
Floral colour change is a widespread phenomenon in angiosperms, but poorly understood from the genetic and chemical point of view. This article investigates this phenomenon in Pleroma raddianum, a Brazilian endemic species whose flowers change from w
Externí odkaz:
https://doaj.org/article/df112afaccb341b1b2df13874c6991fb
Autor:
Fernanda Mendes Rezende, Marcelo José Pena Ferreira, Mads Hartvig Clausen, Magdalena Rossi, Claudia Maria Furlan
Publikováno v:
Molecules, Vol 24, Iss 4, p 718 (2019)
Tibouchina pulchra (Cham.) Cogn. is a plant native to Brazil whose genus and family (Melastomataceae) are poorly studied with regards to its metabolite profile. Phenolic pigments of pink flowers were studied by ultra-performance liquid chromatography
Externí odkaz:
https://doaj.org/article/f4719574212149709ddef7a3c375f6c1
Autor:
Sang-Woo Lee, Kim Tai Tran, Ruben Vazquez-Uribe, Charlotte Held Gotfredsen, Mads Hartvig Clausen, Blanca Lopez Mendez, Guillermo Montoya, Anders Bach, Morten Otto Alexander Sommer
Publikováno v:
Lee, S-W, Tran, K T, Vazquez-Uribe, R, Gotfredsen, C H, Clausen, M H, Mendez, B L, Montoya, G, Bach, A & Sommer, M O A 2022, ' Identification and Optimization of Novel Small-Molecule Cas9 Inhibitors by Cell-Based High-Throughput Screening ', Journal of Medicinal Chemistry, vol. 65, no. 4, pp. 3266–3305 . https://doi.org/10.1021/acs.jmedchem.1c01834
CRISPR/Cas9 has revolutionized several areas of life science; however, methods to control the Cas9 activity are needed for both scientific and therapeutic applications. Anti-CRISPR proteins are known to inhibit the CRISPR/Cas adaptive immunity; howev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3c9b9a2c544d4af95a51a7ce0a14b9a
https://doi.org/10.1021/acs.jmedchem.1c01834
https://doi.org/10.1021/acs.jmedchem.1c01834
Autor:
Cecilia Romanò, Enzo Mancuso, Philipp J. Gritsch, Mads Hartvig Clausen, Nino Trattnig, Paul Kosma
Publikováno v:
Mancuso, E, Romanò, C, Trattnig, N, Gritsch, P, Kosma, P & Clausen, M H 2021, ' Rhamnogalacturonan II-Chemical Synthesis of a Substructure Including α-2,3-Linked Kdo ', Chemistry-A European Journal, vol. 27, no. 24, pp. 7099-7102 . https://doi.org/10.1002/chem.202100837
The synthesis of a fully deprotected Kdo-containing rhamnogalacturonan II pentasaccharide is described. The strategy relies on the preparation of a suitably protected homogalacturonan tetrasaccharide backbone through a post-glycosylation oxidation ap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b1fd0bcbf00bf079fd2216971731548
https://doi.org/10.1002/chem.202100837
https://doi.org/10.1002/chem.202100837
Autor:
Mads Hartvig Clausen, Cecilia Romanò
Publikováno v:
Romanò, C & Clausen, M H 2022, ' Chemical Biology of αGalCer : A Chemist’s Toolbox for the Stimulation of Invariant Natural Killer T (iNKT) Cells ', European Journal of Organic Chemistry, vol. 2022, no. 26, e202200246 . https://doi.org/10.1002/ejoc.202200246
Often referred to as the “Swiss Army knife” of the immune system, invariant natural killer T (iNKT) cells are a subpopulation of T lymphocytes stimulated by the synthetic glycolipid α-galactosylceramide (αGalCer) when in complex with the CD1d r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1e9ea0f7dc1c3696c038cbeab9ca49a
https://doi.org/10.1002/ejoc.202200246
https://doi.org/10.1002/ejoc.202200246
Autor:
Mario Wibowo, Jette Melchiorsen, Lone Gram, Ling Ding, Elisa Sassetti, Charlotte Held Gotfredsen, Mads Hartvig Clausen
Publikováno v:
Journal of Natural Products
Wibowo, M, Gotfredsen, C H, Sassetti, E, Melchiorsen, J, Clausen, M H, Gram, L & Ding, L 2020, ' Azodyrecins A-C: Azoxides from a Soil-Derived Streptomyces Species ', Journal of Natural Products, vol. 83, no. 12, pp. 3519-3525 . https://doi.org/10.1021/acs.jnatprod.0c00339
Wibowo, M, Gotfredsen, C H, Sassetti, E, Melchiorsen, J, Clausen, M H, Gram, L & Ding, L 2020, ' Azodyrecins A-C: Azoxides from a Soil-Derived Streptomyces Species ', Journal of Natural Products, vol. 83, no. 12, pp. 3519-3525 . https://doi.org/10.1021/acs.jnatprod.0c00339
Azoxy compounds belong to a small group of natural products sharing a common functional group with the general structure RN = N+(O-)R. Three new azoxides, azodyrecins A-C (1-3), were isolated from a soil-derived Streptomyces sp. strain P8-A2. The cis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f4fd25c9caee8ef83bc1c7d6a110286
https://doi.org/10.1021/acs.jnatprod.0c00339
https://doi.org/10.1021/acs.jnatprod.0c00339
A Glycan Array‐Based Assay for the Identification and Characterization of Plant Glycosyltransferases
Autor:
Max Peter Bartetzko, Michael G. Hahn, Digantkumar Chapla, Colin Ruprecht, Peter J. Smith, Hyunil Oh, Anna Lakhina, Maria J. Soto, Daniel Varón Silva, Mads Hartvig Clausen, Jeong-Yeh Yang, Deborah Senf, Fabian Pfrengle, Kelley W. Moremen, Breeanna R. Urbanowicz
Publikováno v:
Angewandte Chemie (International Ed. in English)
Ruprecht, C, Bartetzko, M P, Senf, D, Lakhina, A, Smith, P J, Soto, M J, Oh, H, Yang, J-Y, Chapla, D, Silva, D V, Clausen, M H, Hahn, M G, Moremen, K W, Urbanowicz, B R & Pfrengle, F 2020, ' A Glycan Array-Based Assay for the Identification and Characterization of Plant Glycosyltransferases ', Angewandte Chemie, vol. 132, pp. 12593-1259 . https://doi.org/10.1002/ange.202003105
Angewandte Chemie International Edition
Angewandte Chemie
Ruprecht, C, Bartetzko, M P, Senf, D, Lakhina, A, Smith, P J, Soto, M J, Oh, H, Yang, J-Y, Chapla, D, Silva, D V, Clausen, M H, Hahn, M G, Moremen, K W, Urbanowicz, B R & Pfrengle, F 2020, ' A Glycan Array-Based Assay for the Identification and Characterization of Plant Glycosyltransferases ', Angewandte Chemie International Edition, vol. 59, no. 30, pp. 12493–12498 . https://doi.org/10.1002/anie.202003105
Ruprecht, C, Bartetzko, M P, Senf, D, Lakhina, A, Smith, P J, Soto, M J, Oh, H, Yang, J-Y, Chapla, D, Silva, D V, Clausen, M H, Hahn, M G, Moremen, K W, Urbanowicz, B R & Pfrengle, F 2020, ' A Glycan Array-Based Assay for the Identification and Characterization of Plant Glycosyltransferases ', Angewandte Chemie, vol. 132, pp. 12593-1259 . https://doi.org/10.1002/ange.202003105
Angewandte Chemie International Edition
Angewandte Chemie
Ruprecht, C, Bartetzko, M P, Senf, D, Lakhina, A, Smith, P J, Soto, M J, Oh, H, Yang, J-Y, Chapla, D, Silva, D V, Clausen, M H, Hahn, M G, Moremen, K W, Urbanowicz, B R & Pfrengle, F 2020, ' A Glycan Array-Based Assay for the Identification and Characterization of Plant Glycosyltransferases ', Angewandte Chemie International Edition, vol. 59, no. 30, pp. 12493–12498 . https://doi.org/10.1002/anie.202003105
Growing plants with modified cell wall compositions is a promising strategy to improve resistance to pathogens, increase biomass digestibility, and tune other important properties. In order to alter biomass architecture, a detailed knowledge of cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40b078330ed1372b0095263891d41ad5
https://doi.org/10.1002/ange.202003105
https://doi.org/10.1002/ange.202003105