Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Mads Dyrvig"'
Autor:
Mads Dyrvig, Per Qvist, Jacek Lichota, Knud Larsen, Mette Nyegaard, Anders D Børglum, Jane H Christensen
Publikováno v:
PLoS ONE, Vol 12, Iss 1, p e0170121 (2017)
The bromodomain containing 1 gene, BRD1 is essential for embryogenesis and CNS development. It encodes a protein that participates in histone modifying complexes and thereby regulates the expression of a large number of genes. Genetic variants in the
Externí odkaz:
https://doaj.org/article/033937e3b6484e4bbe840f95e9744fce
Publikováno v:
Dyrvig, M, Mikkelsen, J D & Lichota, J 2019, ' DNA methylation regulates CHRNA7 transcription and can be modulated by valproate ', Neuroscience Letters, vol. 704, pp. 145-152 . https://doi.org/10.1016/j.neulet.2019.04.015
The CHRNA7 gene encoding the α7 nicotinic acetylcholine receptor (nAChR) has repeatedly been linked with schizophrenia and the P50 sensory gating deficit. The α7 nAChR is considered a promising drug target for treatment of cognitive dysfunction in
Autor:
Knud Larsen, Jane H. Christensen, Mette Nyegaard, Per Qvist, Jacek Lichota, Anders D. Børglum, Mads Dyrvig
Publikováno v:
PLoS ONE, Vol 12, Iss 1, p e0170121 (2017)
Dyrvig, M, Qvist, P, Lichota, J, Larsen, K, Nyegaard, M, Børglum, A D & Christensen, J H 2017, ' DNA methylation analysis of BRD1 promoter regions and the schizophrenia rs138880 risk allele ', PLOS ONE, vol. 12, no. 1, e0170121 . https://doi.org/10.1371/journal.pone.0170121
PLoS ONE
Johannesen, M D, Qvist, P, Lichota, J, Larsen, K E, Nyegaard, M, Børglum, A D & Christensen, J H 2017, ' DNA Methylation Analysis of BRD1 Promoter Regions and the Schizophrenia rs138880 Risk Allele ', P L o S One, vol. 12, no. 1, e0170121 . https://doi.org/10.1371/journal.pone.0170121
Dyrvig, M, Qvist, P, Lichota, J, Larsen, K, Nyegaard, M, Børglum, A D & Christensen, J H 2017, ' DNA methylation analysis of BRD1 promoter regions and the schizophrenia rs138880 risk allele ', PLOS ONE, vol. 12, no. 1, e0170121 . https://doi.org/10.1371/journal.pone.0170121
PLoS ONE
Johannesen, M D, Qvist, P, Lichota, J, Larsen, K E, Nyegaard, M, Børglum, A D & Christensen, J H 2017, ' DNA Methylation Analysis of BRD1 Promoter Regions and the Schizophrenia rs138880 Risk Allele ', P L o S One, vol. 12, no. 1, e0170121 . https://doi.org/10.1371/journal.pone.0170121
The bromodomain containing 1 gene, BRD1 is essential for embryogenesis and CNS development. It encodes a protein that participates in histone modifying complexes and thereby regulates the expression of a large number of genes. Genetic variants in the
Autor:
Mads E. Hauberg, Kimmo Jensen, Anto P. Rajkumar, Ole Mors, Ernst-Martin Füchtbauer, Kim Fejgin, Jonatan Pallesen, Irina Vardya, Veerle Paternoster, Mads Dyrvig, Arne Mørk, Birgitte Lundsberg, Jane H. Christensen, Tue Fryland, Mette Nyegaard, Per Qvist, Anders D. Børglum, Jens R. Nyengaard, Michael Didriksen
Publikováno v:
Qvist, P, Christensen, J H, Vardya, I, Rajkumar, A P, Mørk, A, Paternoster, V, Füchtbauer, E-M, Pallesen, J, Fryland, T, Dyrvig, M, Hauberg, M E, Lundsberg, B, Fejgin, K, Nyegaard, M, Jensen, K, Nyengaard, J R, Mors, O, Didriksen, M & Børglum, A D 2017, ' The schizophrenia-associated BRD1 gene regulates behavior, neurotransmission, and expression of schizophrenia risk enriched gene sets in mice ', Biological Psychiatry, vol. 82, no. 1, pp. 62-76 . https://doi.org/10.1016/j.biopsych.2016.08.037
Qvist, P, Christensen, J H, Vardya, I, Rajkumar, A P, Mørk, A, Paternoster, V, Füchtbauer, E-M, Pallesen, J, Fryland, T, Dyrvig, M, Hauberg, M E, Lundsberg, B, Fejgin, K, Nyegaard, M, Jensen, K, Nyengaard, J R, Mors, O, Didriksen, M & Børglum, A D 2017, ' The Schizophrenia-Associated BRD1 Gene Regulates Behavior, Neurotransmission, and Expression of Schizophrenia Risk Enriched Gene Sets in Mice ', Biological Psychiatry, vol. 82, no. 1, pp. 62-76 . https://doi.org/10.1016/j.biopsych.2016.08.037
Qvist, P, Christensen, J H, Vardya, I, Rajkumar, A P, Mørk, A, Paternoster, V, Füchtbauer, E-M, Pallesen, J, Fryland, T, Dyrvig, M, Hauberg, M E, Lundsberg, B, Fejgin, K, Nyegaard, M, Jensen, K, Nyengaard, J R, Mors, O, Didriksen, M & Børglum, A D 2016, ' The schizophrenia associated BRD1 gene regulates behavior, neurotransmission, and expression of schizophrenia risk enriched gene sets in mice ', Biological psychiatry . https://doi.org/10.1016/j.biopsych.2016.08.037
Qvist, P, Christensen, J H, Vardya, I, Rajkumar, A P, Mørk, A, Paternoster, V, Füchtbauer, E-M, Pallesen, J, Fryland, T, Dyrvig, M, Hauberg, M E, Lundsberg, B, Fejgin, K, Nyegaard, M, Jensen, K, Nyengaard, J R, Mors, O, Didriksen, M & Børglum, A D 2017, ' The Schizophrenia-Associated BRD1 Gene Regulates Behavior, Neurotransmission, and Expression of Schizophrenia Risk Enriched Gene Sets in Mice ', Biological Psychiatry, vol. 82, no. 1, pp. 62-76 . https://doi.org/10.1016/j.biopsych.2016.08.037
Qvist, P, Christensen, J H, Vardya, I, Rajkumar, A P, Mørk, A, Paternoster, V, Füchtbauer, E-M, Pallesen, J, Fryland, T, Dyrvig, M, Hauberg, M E, Lundsberg, B, Fejgin, K, Nyegaard, M, Jensen, K, Nyengaard, J R, Mors, O, Didriksen, M & Børglum, A D 2016, ' The schizophrenia associated BRD1 gene regulates behavior, neurotransmission, and expression of schizophrenia risk enriched gene sets in mice ', Biological psychiatry . https://doi.org/10.1016/j.biopsych.2016.08.037
Background The schizophrenia-associated BRD1 gene encodes a transcriptional regulator whose comprehensive chromatin interactome is enriched with schizophrenia risk genes. However, the biology underlying the disease association of BRD1 remains specula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7197cdf2a824af3d701dbcabe7526cbc
https://vbn.aau.dk/da/publications/8469c96c-3ae2-4a7d-b7d0-ab3dd45c4d45
https://vbn.aau.dk/da/publications/8469c96c-3ae2-4a7d-b7d0-ab3dd45c4d45
Autor:
Christensen, Jane H., Mads Dyrvig, Per Qvist, Jacek Lichota, Knud Larsen, Mette Nyegaard, Børglum, Anders D.
Publikováno v:
Christensen, J H, Dyrvig, M, Qvist, P, Lichota, J, Larsen, K, Nyegaard, M & Børglum, A D 2016, ' Differential methylation of promoter regions and the schizophrenia rs138880 risk allele affects expression of BRD1 ', FENS Forum of Neuroscience, Copenhagen, Denmark, 02/07/2016-06/07/2016 . < https://ep70.eventpilot.us/web/page.php?page=IntHtml&project=FENS16&id=abstract_196174 >
Aalborg University
Aalborg University
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::13c47731566f4dc204631b3872cfc365
https://vbn.aau.dk/da/publications/d92c152c-bed9-4224-9435-f10f9649d3de
https://vbn.aau.dk/da/publications/d92c152c-bed9-4224-9435-f10f9649d3de
Publikováno v:
Lichota, J, Dyrvig, M & Mikkelsen, J D 2016, Epigenetic regulation of human nicotinic acetylcholine receptor gene promoter . in 46th Annual Meeting of the Society for Neuroscience, Neuroscience 2016, 12-16 November 2016, San Diego, CA, USA ., 650.15 / NNN36, Society for Neuroscience, Annual Meeting of the Society for Neuroscience, San Diego, CA, United States, 12/11/2016 . < http://www.abstractsonline.com/pp8/#!/4071/presentation/31753 >
Aalborg University
Aalborg University
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::c065929902adf284e97be98cdfbec377
https://vbn.aau.dk/da/publications/03a77003-c038-48d8-af53-ae38a71600af
https://vbn.aau.dk/da/publications/03a77003-c038-48d8-af53-ae38a71600af
Autor:
Jens Damsgaard Mikkelsen, Mads Dyrvig, Jacek Lichota, Henrik H. Hansen, David P.D. Woldbye, Søren H. Christiansen
Publikováno v:
Johannesen, M D, Hansen, H H, Christiansen, S H, Woldbye, D P D, Mikkelsen, J D & Lichota, J 2012, ' Epigenetic regulation of Arc and c-Fos in the hippocampus after acute electroconvulsive stimulation in the rat ', Brain Research Bulletin, vol. 88, no. 5, pp. 507–513 . https://doi.org/10.1016/j.brainresbull.2012.05.004
Electroconvulsive stimulation (ECS) remains one of the most effective treatments of major depression. However, the underlying molecular changes still remain to be elucidated. Since ECS causes rapid and significant changes in gene expression we have l
Publikováno v:
Dyrvig, M, Gøtzsche, C R, Woldbye, D P D & Lichota, J 2015, ' Epigenetic regulation of Dnmt3a and Arc gene expression after electroconvulsive stimulation in the rat ', Molecular and Cellular Neuroscience, vol. 67, pp. 137-143 . https://doi.org/10.1016/j.mcn.2015.06.011
Electroconvulsive therapy (ECT) remains one of the most effective treatments of major depression. Unfortunately, some patients report side effects, of which the most prominent are memory deficits. The immediate early gene Arc plays a critical role in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60e83264ad18958d4b746de3780855b2
https://vbn.aau.dk/da/publications/5a9dc8ae-174f-4099-b668-1cbe678efa44
https://vbn.aau.dk/da/publications/5a9dc8ae-174f-4099-b668-1cbe678efa44
Publikováno v:
Johannesen, M D, Christiansen, S H, Woldbye, D P D & Lichota, J 2014, ' Temporal gene expression profile after acute electroconvulsive stimulation in the rat ', Gene, vol. 539, no. 1, pp. 8-14 . https://doi.org/10.1016/j.gene.2014.01.072
Electroconvulsive therapy (ECT) remains one of the most effective treatments of major depression. It has been suggested that the mechanisms of action involve gene expression. In recent decades there have been several investigations of gene expression
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de19d84ea085c0e447b783304c4aadf6
https://vbn.aau.dk/da/publications/5a0914ab-4bea-4957-a896-14495f33fc03
https://vbn.aau.dk/da/publications/5a0914ab-4bea-4957-a896-14495f33fc03
Autor:
Elena V. Bouzinova, Mads Dyrvig, Kim Henningsen, Jesper T. Andreasen, Jacek Lichota, Rupert Palme, Sofie Christiansen, Trine Christensen, Ove Wiborg
Publikováno v:
Henningsen, K, Johannesen, M D, Bouzinova, E, Christiansen, S, Christensen, T, Andreasen, J T, Palme, R, Lichota, J & Wiborg, O 2012, ' Low maternal care exacerbates adult stress susceptibility in the chronic mild stress rat model of depression ', Behavioural Pharmacology, vol. 23, no. 8, pp. 735-743 . https://doi.org/10.1097/FBP.0b013e32835a5184
Henningsen, K, Dyrvig, M, Bouzinova, E V, Christiansen, S, Christensen, T, Andreasen, J T, Palme, R, Lichota, J & Wiborg, O 2012, ' Low maternal care exacerbates adult stress susceptibility in the chronic mild stress rat model of depression ', Behavioural Pharmacology, vol. 23, no. 8, pp. 735-43 . https://doi.org/10.1097/FBP.0b013e32835a5184
Henningsen, K, Dyrvig, M, Bouzinova, E V, Christiansen, S, Christensen, T, Andreasen, J T, Palme, R, Lichota, J & Wiborg, O 2012, ' Low maternal care exacerbates adult stress susceptibility in the chronic mild stress rat model of depression ', Behavioural Pharmacology, vol. 23, no. 8, pp. 735-43 . https://doi.org/10.1097/FBP.0b013e32835a5184
In the present study we report the finding that the quality of maternal care, in early life, increased the susceptibility to stress exposure in adulthood, when rats were exposed to the chronic mild stress paradigm. Our results indicate that high, as