Výsledky vyhledávání

Comparison of pharmacokinetic study profiles of insulin in rat plasma through conventional sampling and microsampling by micro-LC–MS/MS

Autor: Gaudry Bruno Troché, Tue Søeborg, Thóra Brynja Bödvarsdottir, Mads Bjelke, Nikoline Juul Nielsen

Publikováno v: Bioanalysis. 15:283-294

Aim: With microsamples of blood, full pharmacokinetic profiles from individual animals can be obtained as an alternative to the sparse-sampling approach, where conventional volume samples from several animals are required. However, microsamples requi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::db849092278d0a80c0a2af3c28ff7512
https://doi.org/10.4155/bio-2023-0006

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A novel next‐generation FVIIIa mimetic, Mim8, has a favorable safety profile and displays potent pharmacodynamic effects: Results from safety studies in cynomolgus monkeys

Autor: Brian Lauritzen, Mads Bjelke, Olle Björkdahl, Esther Bloem, Kevin Keane, Marianne Kjalke, Marie Rossen, Solvej Lund Lippert, Karin Nana Weldingh, Mikala Skydsgaard, Stine Kjellev

Publikováno v: Journal of Thrombosis and Haemostasis. 20:1312-1324

Mim8 is a novel, next-generation factor VIIIa mimetic in development for subcutaneous prophylactic treatment of patients with hemophilia A with and without inhibitors. In vitro and in vivo models indicate that Mim8 has a distinct hemostatic potential

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8a297c1a3dbd1aa78cc4af6bf7161de
https://doi.org/10.1111/jth.15682

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Structure identification of circulating metabolites from somapacitan, a long-acting growth hormone derivative, and pharmacokinetics after single and multiple subcutaneous dosing in rats

Autor: Hans Helleberg, Mads Bjelke, Peter Thygesen, Rikke Hvid Lindecrona

Publikováno v: European Journal of Pharmaceutical Sciences. 168:106032

Somapacitan is a growth hormone derivative approved for once-weekly treatment of growth hormone deficiency in adults and currently in clinical development for once-weekly dosing in children. The purpose of this study was to obtain non-clinical data f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2ec13ade70e7a60dbb41b8cd11c8fb8
https://doi.org/10.1016/j.ejps.2021.106032

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Knowledge lost - or gained? The changing knowledge base of Danish social work

Autor: Mads Bjelke Damgaard, Anna Olejasz Lyneborg

Publikováno v: Lyneborg, A O & Damgaard, M B 2019, ' Knowledge lost-or gained? The changing knowledge base of Danish social work ', Nordic Social Work Research, vol. 9, no. 3, pp. 206-219 . https://doi.org/10.1080/2156857X.2018.1494031

As the institutional setting and conditions of Danish social work have changed to attain new levels of efficiency, social work practice has changed substantially. The demands for social services of high quality have intensified as a result of high pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9eb6cc5571bd8044527b4fe091d25fe2
https://doi.org/10.1080/2156857x.2018.1494031

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A Novel Next-Generation FVIII Mimetic, Mim8, Has a Favourable Safety Profile. Results from a 26-Week Safety Study in Cynomolgus Monkeys

Autor: Brian Lauritzen, Marie Rossen, Mads Bjelke, Olle Björkdahl, Stine Kjellev, Marianne Kjalke, Mikala Skydsgaard

Publikováno v: Blood. 136:26-27

Introduction Mim8 is in clinical development as a novel, next generation FVIII mimetic for subcutaneous prophylactic treatment for people with Hemophilia A (HA) with and without inhibitors. Mim8 is a fully human bispecific antibody bridging FIXa and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7f2f41ff5c33c5655fd75caabcab0aae
https://doi.org/10.1182/blood-2020-137006

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Elektronická kniha

Media Leaks and Corruption in Brazil : The Infostorm of Impeachment and the Lava-Jato Scandal

Autor: Mads Bjelke Damgaard

Analyzing the political consequences of the most extensive corruption investigation in recent Latin American history, Operação Lava-Jato, Media Leaks and Corruption in Brazil answers two central questions about the contradictory effects news media

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Car Wash, Crisis, and Political Cataclysm:Corruption Narratives in the Brazilian Mediascape

Autor: Damgaard, Mads Bjelke

Publikováno v: Damgaard, M B 2018, Car Wash, Crisis, and Political Cataclysm : Corruption Narratives in the Brazilian Mediascape . Det Humanistiske Fakultet, Københavns Universitet .

A wave of corruption disclosure, leaks, and media exposés engulfed the Brazilian democracy in the period 2014–2018. Below the surface of an uncommonly successful investigation into high-level corruption, undercurrents of political crisis swept Pre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______2751::b7dd8270768eaef12a7e9ddd72656176
https://curis.ku.dk/portal/da/publications/car-wash-crisis-and-political-cataclysm(28827ec0-a446-4edb-a5cd-9d8aa67edf6b).html

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Administration of recombinant FVIIa (rFVIIa) to concizumab-dosed monkeys is safe, and concizumab does not affect the potency of rFVIIa in hemophilic rabbits

Autor: Kristoffer W. Balling, Brian Lauritzen, Janne Olling, Mads Bjelke, Cecilia Augustsson, Ida Hilden, Anne Charlotte Hegelund, Kristin L. Abel

Publikováno v: Journal of thrombosis and haemostasis : JTH. 17(3)

Essentials Hemophilia patients on concizumab prophylaxis may need rFVIIa to treat breakthrough bleeds. Effect and safety of concizumab + rFVIIa were tested in vitro and in vivo. Concizumab + rFVIIa had no additive effects on bleeding in hemophilic ra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::528632585c3f57299874fefbf22845cf
https://pubmed.ncbi.nlm.nih.gov/30614620

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