Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Madoka Nakagomi"'
Autor:
Jonghyuk Park, Takahiro Masaki, Yoshihiro Mezaki, Hiroshi Yokoyama, Mariko Nakamura, Haruka Maehashi, Takahiko J Fujimi, Sabine S Gouraud, Keisuke Nagatsuma, Madoka Nakagomi, Naofumi Kimura, Tomokazu Matsuura
Publikováno v:
PLoS ONE, Vol 12, Iss 12, p e0189346 (2017)
We developed a bio-artificial liver (BAL) using a radial-flow bioreactor and rescued mini-pig models with lethal acute liver failure (ALF). The point of the rescue is the recovery from hepatic encephalopathy (HE). HE on ALF has sometimes resulted in
Externí odkaz:
https://doaj.org/article/b6537d1327ff4c668cb7a53d8a4d32d7
Autor:
Madoka Nakagomi, Nobuko Fujimaki, Ai Ito, Takahiro Toda, Hiroshi Fukasawa, Koichi Shudo, Ryoichi Tomita
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e75445 (2013)
Firefly luciferase (Luc) is widely used as a reporter enzyme in cell-based assays for gene expression. A novel aromatic carboxylic acid, F-53, reported here for the first time, substantially inhibited the enzymatic activity of Luc in a Luc reporter s
Externí odkaz:
https://doaj.org/article/e0b3d1ec9ff04663a3e815125babd1fa
Publikováno v:
Heterocycles
Firefly luciferase is used in high-throughput screening based on the detection of chemiluminescence. It catalyzes an esterification reaction of luciferin with adenosine 5’-triphosphate (ATP) followed by decarbonylation with oxygen and concomitance
Publikováno v:
Journal of Applied Toxicology. 38:688-695
Bisphenol A (BPA), 4-nonylphenol (NP) and butyl benzyl phthalate (BBP), termed endocrine-disrupting chemicals, are known to mimic estrogen activity. The effects of these chemicals on 17β-estradiol (E2 ) metabolism in vivo in rats were examined. Male
Publikováno v:
Journal of applied toxicology : JAT. 38(5)
Bisphenol A (BPA), 4-nonylphenol (NP) and butyl benzyl phthalate (BBP), termed endocrine-disrupting chemicals, are known to mimic estrogen activity. The effects of these chemicals on 17β-estradiol (E
Autor:
Takahiro Masaki, Keisuke Nagatsuma, Yoshihiro Mezaki, Naofumi Kimura, Madoka Nakagomi, Tomokazu Matsuura, Mariko Nakamura, Hiroshi Yokoyama, Sabine S. Gouraud, Jonghyuk Park, Takahiko J. Fujimi, Haruka Maehashi
Publikováno v:
PLoS ONE, Vol 12, Iss 12, p e0189346 (2017)
PLoS ONE
PLoS ONE
Background and aims We developed a bio-artificial liver (BAL) using a radial-flow bioreactor and rescued mini-pig models with lethal acute liver failure (ALF). The point of the rescue is the recovery from hepatic encephalopathy (HE). HE on ALF has so
Autor:
Kohichi Kawahara, Yukihiko Sugimoto, Hiroshi Fukasawa, Michita Suenobu, Madoka Nakagomi, Akihiko Kuniyasu, Hideyuki Ohtsuka, Koichi Shudo, Hitoshi Nakayama
Publikováno v:
Journal of Alzheimer's Disease. 42:587-605
Alzheimer's disease (AD) is a neurodegenerative process involving amyloid-β (Aβ) peptide deposition, neuroinflammation, and progressive memory loss. Here, we evaluated whether oral administration of retinoic acid receptor (RAR)α,β agonist Am80 (t
Autor:
Masaharu Nakamura, Yuichi Hashimoto, Madoka Nakagomi, Masahiko Nakamura, Hirozumi Toyama, Yotaro Matsumoto
Publikováno v:
Bioorganic & Medicinal Chemistry. 22:1948-1959
Retinoic acid receptor (RAR)-related orphan receptors (RORs) regulate a variety of physiological processes, including hepatic gluconeogenesis, lipid metabolism, circadian rhythm and immune function. The RAR agonist: all-trans retinoic acid was report
Autor:
Madoka Nakagomi, Emako Suzuki
Publikováno v:
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 1060
15α-Hydroxyestrogens (15α-OHEs) are metabolites of the female hormone estradiol. In this study, to discover physiological markers that can be utilized for monitoring fetal conditions and estrogen-induced cancers, we established a method for quantif
Publikováno v:
Pharmacology Biochemistry and Behavior. 104:1-9
Am80 is a synthetic retinoid that has been used clinically for patients with acute promyelocytic leukemia and has been reported to affect the brain and its neurons. We investigated the influence of Am80 on anti-anxiety-like behavior, which is a chara