Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Madison T. Wright"'
Autor:
Alexander Munden, Madison T. Wright, Dongsheng Han, Reyhaneh Tirgar, Lars Plate, Jared T. Nordman
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract Replication of the eukaryotic genome requires the formation of thousands of replication forks that must work in concert to accurately replicate the genetic and epigenetic information. Defining replication fork-associated proteins is a key st
Externí odkaz:
https://doaj.org/article/bf3c61eb9a554ecd80c35d1ef55d5ddc
Autor:
Pablo Rozas, Cristina Pinto, Francisca Martínez Traub, Rodrigo Díaz, Viviana Pérez, Daniela Becerra, Patricia Ojeda, Jorge Ojeda, Madison T. Wright, Jessica Mella, Lars Plate, Juan Pablo Henríquez, Claudio Hetz, Danilo B. Medinas
Publikováno v:
Acta Neuropathologica Communications, Vol 9, Iss 1, Pp 1-17 (2021)
Abstract Amyotrophic lateral sclerosis (ALS) is a progressive fatal neurodegenerative disease that affects motoneurons. Mutations in superoxide dismutase 1 (SOD1) have been described as a causative genetic factor for ALS. Mice overexpressing ALS-link
Externí odkaz:
https://doaj.org/article/c57fbc2a7aa8401fb63f027829c4e9a4
Autor:
Madison T Wright, Bibek Timalsina, Valeria Garcia Lopez, Jake N Hermanson, Sarah Garcia, Lars Plate
Publikováno v:
Molecular Systems Biology, Vol 20, Iss 9, Pp 1049-1075 (2024)
Abstract Many cellular processes are governed by protein–protein interactions that require tight spatial and temporal regulation. Accordingly, it is necessary to understand the dynamics of these interactions to fully comprehend and elucidate cellul
Externí odkaz:
https://doaj.org/article/d5370b4873344f5fb352cd1e6022d881
SUMMARYMany cellular processes are governed by protein-protein interactions that require tight spatial and temporal regulation. Accordingly, it is necessary to understand the dynamics of protein interactions to fully comprehend and elucidate cellular
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5f108b20b15f6e65de6bd0958328426c
https://doi.org/10.1101/2022.09.04.506558
https://doi.org/10.1101/2022.09.04.506558
Autor:
Danilo Bilches Medinas, Sajid Malik, Esra Yıldız‐Bölükbaşı, Janina Borgonovo, Mirva J Saaranen, Hery Urra, Eduardo Pulgar, Muhammad Afzal, Darwin Contreras, Madison T Wright, Felipe Bodaleo, Gabriel Quiroz, Pablo Rozas, Sara Mumtaz, Rodrigo Díaz, Carlos Rozas, Felipe Cabral‐Miranda, Ricardo Piña, Vicente Valenzuela, Ozgun Uyan, Christopher Reardon, Ute Woehlbier, Robert H Brown, Miguel Sena‐Esteves, Christian Gonzalez‐Billault, Bernardo Morales, Lars Plate, Lloyd W Ruddock, Miguel L Concha, Claudio Hetz, Aslıhan Tolun
Publikováno v:
EMBO J
Recessive gene mutations underlie many developmental disorders and often lead to disabling neurological problems. Here, we report identification of a homozygous c.170G>A (p.Cys57Tyr or C57Y) mutation in the gene coding for protein disulfide isomerase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6613e8538ac476726f6e672a582c42a8
https://europepmc.org/articles/PMC8762563/
https://europepmc.org/articles/PMC8762563/
Autor:
Michael R. Savona, Paul Brent Ferrell, Bradley I. Reinfeld, Brian O. Bachmann, Madison T. Wright, Gary A. Sulikowski, Rathmell Wk, John L. Rubinstein, Lars Plate, Haiyang Guo, Benjamin J. Reisman, Haley E. Ramsey
Cancer cells have long been recognized to exhibit unique bioenergetic requirements. The apoptolidin family of glycomacrolides are distinguished by their selective cytotoxicity towards oncogene transformed cells, yet their molecular mechanism remains
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6461d9d11637bdcf143daa04267a41c1
https://doi.org/10.1101/2021.05.31.445492
https://doi.org/10.1101/2021.05.31.445492
Autor:
P. Brent Ferrell, Madison T. Wright, Benjamin J. Reisman, Lars Plate, Hui Guo, Bradley I. Reinfeld, Michael R. Savona, Brian O. Bachmann, Gary A. Sulikowski, W. Kimryn Rathmell, John L. Rubinstein, Haley E. Ramsey
Publikováno v:
Nature chemical biology. 18(4)
Cancer cells have long been recognized to exhibit unique bioenergetic requirements. The apoptolidin family of glycomacrolides are distinguished by their selective cytotoxicity towards oncogene-transformed cells, yet their molecular mechanism remains
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd2a8eef8d7705a6ccd271bc4aa7588c
https://pubmed.ncbi.nlm.nih.gov/34857957
https://pubmed.ncbi.nlm.nih.gov/34857957
Autor:
Danilo B. Medinas, Madison T. Wright, Claudio Hetz, Pablo Rozas, Rodrigo Díaz, Jorge Ojeda, Lars Plate, Daniela Becerra, Viviana Pérez, Patricia Ojeda, Juan Pablo Henríquez, Jessica Mella, Cristina Pinto, Francisca Martínez Traub
Publikováno v:
Acta Neuropathologica Communications
Acta Neuropathologica Communications, Vol 9, Iss 1, Pp 1-17 (2021)
Acta Neuropathologica Communications, Vol 9, Iss 1, Pp 1-17 (2021)
Amyotrophic lateral sclerosis (ALS) is a progressive fatal neurodegenerative disease that affects motoneurons. Mutations in superoxide dismutase 1 (SOD1) have been described as a causative genetic factor for ALS. Mice overexpressing ALS-linked mutant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54cc186541fd654657488512250b2f9d
https://doi.org/10.1186/s40478-020-01116-z
https://doi.org/10.1186/s40478-020-01116-z
Autor:
Darren R. Heintzman, Jonathan P. Schlebach, Madison T. Wright, Katherine R. Clowes, Justin T. Marinko, Lars Plate, Charles R. Sanders
Publikováno v:
The Journal of Biological Chemistry
Peripheral myelin protein 22 (PMP22) folds and trafficks inefficiently, with only 20% of newly expressed protein trafficking to the cell surface. This behavior is exacerbated in many of the mutants associated with Charcot–Marie–Tooth disease, mot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04f7aa822492ff0debb73ba9d1a8ad87
https://pubmed.ncbi.nlm.nih.gov/33933451
https://pubmed.ncbi.nlm.nih.gov/33933451
Publikováno v:
Molecular & Cellular Proteomics : MCP
Thyroglobulin (Tg) is a secreted iodoglycoprotein serving as the precursor for triiodothyronine and thyroxine hormones. Many characterized Tg gene mutations produce secretion-defective variants resulting in congenital hypothyroidism. Tg processing an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d17fb4f57923b89d5f68b68711a933e
https://doi.org/10.1074/mcp.ra120.002168
https://doi.org/10.1074/mcp.ra120.002168