Zobrazeno 1 - 10
of 247
pro vyhledávání: '"Madison S. Spach"'
Publikováno v:
Heart Rhythm. 1:500-515
With the advent of new information about alterations of cardiac gap junctions in disease conditions associated with arrhythmias, there have been major advances in the genetic and metabolic manipulation of gap junctions. In contrast, in naturally occu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9f2b646a756778c9950dbde9ae957707
https://doi.org/10.1016/j.hrthm.2004.06.010
https://doi.org/10.1016/j.hrthm.2004.06.010
Autor:
Madison S. Spach
Publikováno v:
Circulation Research. 101:743-745
See related article, pages 839–847 It is widely known that atrial fibrillation (AF) is the most common sustained cardiac arrhythmia, with the problem magnified by the clinical sequelae; eg, thromboembolic events. It is pertinent that the incidence
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ee804bd7d00191ca4addaf29b179e724
https://doi.org/10.1161/circresaha.107.163956
https://doi.org/10.1161/circresaha.107.163956
Publikováno v:
Circulation Research. 83:1144-1164
Abstract —It has become of fundamental importance to understand variations in the shape of the upstroke of the action potential in order to identify structural loading effects. One component of this goal is a detailed experimental analysis of the t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8c10146d84eb352eb4c66b5f6cba60b
https://doi.org/10.1161/01.res.83.11.1144
https://doi.org/10.1161/01.res.83.11.1144
Autor:
Madison S. Spach
Publikováno v:
International Journal of Bifurcation and Chaos. :1637-1656
The object of this paper is to describe cardiac conduction phenomena caused by the discrete nature of cardiac cellular structure. Recent results show that the myocardial architecture creates inhomogeneities of electrical load at the microscopic level
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3836b621598f5f02211167fc70c13e3b
https://doi.org/10.1142/s0218127496000990
https://doi.org/10.1142/s0218127496000990
Autor:
Madison S. Spach
Publikováno v:
Circulation Research. 88:753-755
Because the myocardium was considered to behave structurally as a continuous medium, for many years attention focused on spatial variations in the membrane properties, which allow some cells to recover excitability faster as the mechanism for reentry
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ca5e3c30872927a67b51025c552b566a
https://doi.org/10.1161/hh0801.090538
https://doi.org/10.1161/hh0801.090538
Background Aging is associated with a significant increase in atrial tachyarrhythmias, especially atrial fibrillation. A macroscopic repolarization gradient created artificially by a stimulus at one site before a premature stimulus from a second site
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31dc8ab8755985acfddd00fe03a98787
https://europepmc.org/articles/PMC1847326/
https://europepmc.org/articles/PMC1847326/
Autor:
David A. Lathrop, Peng Sheng Chen, H. Bradley Nuss, Michael R. Rosen, George J. Rozanski, Jeffrey E. Olgin, Kathryn A. Yamada, Madison S. Spach, Jeanne M. Nerbonne, Roger C. Barr, Jonathan C. Makielski, David J. Callans, Dennis A. Przywara, Philip B. Adamson
Publikováno v:
Heart rhythm. 2(6)
Cardiac arrhythmias continue to pose a major medical challenge and significant public health burden. Atrial fibrillation, the most prevalent arrhythmia, affects more than two million Americans annually and is associated with a twofold increase in mor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b1989c27e99e80a4e3c3fae3345c248
https://pubmed.ncbi.nlm.nih.gov/15922277
https://pubmed.ncbi.nlm.nih.gov/15922277
Publikováno v:
Journal of electrocardiology.
Because gene therapy presents a new frontier in the treatment of arrhythmias, it has become important to know how manipulation of the cellular distribution of proteins changes electrical events within individual cells, and whether these cellular chan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0afda46728366138e215bc771e57e94e
https://pubmed.ncbi.nlm.nih.gov/11781939
https://pubmed.ncbi.nlm.nih.gov/11781939
Publikováno v:
Circulation research. 86(3)
Abstract —The increased incidence of arrhythmias in structural heart disease is accompanied by remodeling of the cellular distribution of gap junctions to a diffuse pattern like that of neonatal cardiomyocytes. Accordingly, it has become important
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db3b97dfcc17593ab78df9fe7990da1e
https://pubmed.ncbi.nlm.nih.gov/10679482
https://pubmed.ncbi.nlm.nih.gov/10679482