Invariant NKT Cells Promote the Development of Highly Cytotoxic Multipotent CXCR3+CCR4+CD8+ T Cells That Mediate Rapid Hepatocyte Allograft Rejection

Autor: Jing Han, Madison M Hart, Ginny L. Bumgardner, Robert T. Warren, Chelsea M Peterson, Bryce A Ringwald, Sachi R Chaudhari, Mahmoud Abdel-Rasoul, Jason M. Zimmerer

Publikováno v: J Immunol

Hepatocyte transplant represents a treatment for metabolic disorders but is limited by immunogenicity. Our prior work identified the critical role of CD8+ T cells, with or without CD4+ T cell help, in mediating hepatocyte rejection. In this study, we

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72bd6691be0e085cab8786d555bd82bd
https://doi.org/10.4049/jimmunol.2100334

Antibody-suppressor CXCR5 ⁺ CD8 ⁺ T cellular therapy ameliorates antibody-mediated rejection following kidney transplant in CCR5 KO mice.

Autor: Zimmerer JM; Department of Surgery, Comprehensive Transplant Center, The Ohio State University, Columbus, Ohio, USA., Han JL; Department of Surgery, Comprehensive Transplant Center, The Ohio State University, Columbus, Ohio, USA.; Biomedical Sciences Graduate Program, The Ohio State University College of Medicine, Columbus, Ohio, USA., Peterson CM; Department of Surgery, Comprehensive Transplant Center, The Ohio State University, Columbus, Ohio, USA., Zeng Q; Center for Regenerative Medicine, The Research Institute at Nationwide Children's Hospital, Columbus, Ohio, USA., Ringwald BA; Medical Student Research Program, The Ohio State University College of Medicine, Columbus, Ohio, USA., Cassol C; Department of Pathology, The Ohio State University, Columbus, Ohio, USA., Chaudhari S; Department of Surgery, Comprehensive Transplant Center, The Ohio State University, Columbus, Ohio, USA., Hart M; Department of Surgery, Comprehensive Transplant Center, The Ohio State University, Columbus, Ohio, USA., Hemminger J; Department of Pathology, The Ohio State University, Columbus, Ohio, USA., Satoskar A; Department of Pathology, The Ohio State University, Columbus, Ohio, USA., Abdel-Rasoul M; Center for Biostatistics, The Ohio State University, Columbus, Ohio, USA., Wang JJ; Department of Surgery, Comprehensive Transplant Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA., Warren RT; Department of Surgery, Comprehensive Transplant Center, The Ohio State University, Columbus, Ohio, USA., Zhang ZJ; Department of Surgery, Comprehensive Transplant Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA., Breuer CK; Center for Regenerative Medicine, The Research Institute at Nationwide Children's Hospital, Columbus, Ohio, USA., Bumgardner GL; Department of Surgery, Comprehensive Transplant Center, The Ohio State University, Columbus, Ohio, USA.

Publikováno v: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons [Am J Transplant] 2022 Jun; Vol. 22 (6), pp. 1550-1563. Date of Electronic Publication: 2022 Feb 15.