Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Madison L. Doolittle"'
Autor:
Madison L. Doolittle, Dominik Saul, Japneet Kaur, Jennifer L. Rowsey, Stephanie J. Vos, Kevin D. Pavelko, Joshua N. Farr, David G. Monroe, Sundeep Khosla
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)
Abstract Senescence drives organismal aging, yet the deep characterization of senescent cells in vivo remains incomplete. Here, we apply mass cytometry by time-of-flight using carefully validated antibodies to analyze senescent cells at single-cell r
Externí odkaz:
https://doaj.org/article/9fa996d1eacd483380e6493e7833f68e
Publikováno v:
JBMR Plus, Vol 7, Iss 10, Pp n/a-n/a (2023)
The regulation of bone mineral density (BMD) is highly influenced by genetics and age. Although genome‐wide association studies (GWAS) for BMD have uncovered many genes through their proximity to associated variants (variant nearest‐neighbor [VNN
Externí odkaz:
https://doaj.org/article/62ba4ba4720b42d3a231ab08683cbcf3
Autor:
Madison L. Doolittle, Brittany A. Eckhardt, Stephanie J. Vos, Sarah Grain, Jennifer L. Rowsey, Ming Ruan, Dominik Saul, Joshua N. Farr, Megan M. Weivoda, Sundeep Khosla, David G. Monroe
Publikováno v:
JBMR Plus, Vol 7, Iss 10, Pp n/a-n/a (2023)
ABSTRACT Estrogen regulates bone mass in women and men, but the underlying cellular mechanisms of estrogen action on bone remain unclear. Although both estrogen receptor (ER)α and ERβ are expressed in bone cells, ERα is the dominant receptor for s
Externí odkaz:
https://doaj.org/article/fce9a970aa3344afb432ff2b7082076c
A new gene set identifies senescent cells and predicts senescence-associated pathways across tissues
Autor:
Dominik Saul, Robyn Laura Kosinsky, Elizabeth J. Atkinson, Madison L. Doolittle, Xu Zhang, Nathan K. LeBrasseur, Robert J. Pignolo, Paul D. Robbins, Laura J. Niedernhofer, Yuji Ikeno, Diana Jurk, João F. Passos, LaTonya J. Hickson, Ailing Xue, David G. Monroe, Tamara Tchkonia, James L. Kirkland, Joshua N. Farr, Sundeep Khosla
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Identification of senescent cells in vivo remains a challenging task. Here the authors present and validate a senescence gene set called SenMayo enriched in human and murine aged tissues.
Externí odkaz:
https://doaj.org/article/e07e402c5be742719a9abae3ab241ab2
Autor:
Japneet Kaur, Dominik Saul, Madison L. Doolittle, Joshua N. Farr, Sundeep Khosla, David G. Monroe
Publikováno v:
JBMR Plus, Vol 7, Iss 6, Pp n/a-n/a (2023)
ABSTRACT Aging is a major risk factor for most chronic diseases, including osteoporosis, and is characterized by an accumulation of senescent cells in various tissues. MicroRNAs (miRNAs) are critical regulators of bone aging and cellular senescence.
Externí odkaz:
https://doaj.org/article/26d0a15186a145048a5618b84caabc90
Autor:
Joshua N. Farr, Dominik Saul, Madison L. Doolittle, Japneet Kaur, Jennifer L. Rowsey, Stephanie J. Vos, Mitchell N. Froemming, Anthony B. Lagnado, Yi Zhu, Megan Weivoda, Yuji Ikeno, Robert J. Pignolo, Laura J. Niedernhofer, Paul D. Robbins, Diana Jurk, João F. Passos, Nathan K. LeBrasseur, Tamara Tchkonia, James L. Kirkland, David G. Monroe, Sundeep Khosla
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 8 (2023)
Clearance of senescent cells (SnCs) can prevent several age-related pathologies, including bone loss. However, the local versus systemic roles of SnCs in mediating tissue dysfunction remain unclear. Thus, we developed a mouse model (p16-LOX-ATTAC) th
Externí odkaz:
https://doaj.org/article/fc80a778d0594c49a7d28805675dc1fe
Autor:
Dominik Saul, David G Monroe, Jennifer L Rowsey, Robyn Laura Kosinsky, Stephanie J Vos, Madison L Doolittle, Joshua N Farr, Sundeep Khosla
Publikováno v:
eLife, Vol 10 (2021)
Senescent cells have detrimental effects across tissues with aging but may have beneficial effects on tissue repair, specifically on skin wound healing. However, the potential role of senescent cells in fracture healing has not been defined. Here, we
Externí odkaz:
https://doaj.org/article/8ba3a1c1e49d4f94bed1c548b3fd0494
Autor:
Parinya Samakkarnthai, Dominik Saul, Lei Zhang, Zaira Aversa, Madison L. Doolittle, Jad G. Sfeir, Japneet Kaur, Elizabeth J. Atkinson, James R. Edwards, Graham G. Russell, Robert J. Pignolo, James L. Kirkland, Tamar Tchkonia, Laura J. Niedernhofer, David G. Monroe, Nathan K. Lebrasseur, Joshua N. Farr, Paul D. Robbins, Sundeep Khosla
Publikováno v:
Aging. 15:3331-3355
Autor:
Madison L Doolittle, Gina M Calabrese, Larry D Mesner, Dana A Godfrey, Robert D Maynard, Cheryl L Ackert-Bicknell, Charles R Farber
Publikováno v:
PLoS Genetics, Vol 16, Iss 6, p e1008805 (2020)
Osteoporosis is a genetic disease characterized by progressive reductions in bone mineral density (BMD) leading to an increased risk of fracture. Over the last decade, genome-wide association studies (GWASs) have identified over 1000 associations for
Externí odkaz:
https://doaj.org/article/ba9084e0cc5e4ca1b66b6852a2ebf052
Autor:
Parinya Samakkarnthai, Dominik Saul, Lei Zhang, Zaira Aversa, Madison L. Doolittle, Jad G. Sfeir, Japneet Kaur, Elizabeth J Atkinson, James R. Edwards, R. Graham G. Russell, Robert J. Pignolo, James L. Kirkland, Tamar Tchkonia, Laura J. Niedernhofer, David G. Monroe, Nathan K. LeBrasseur, Joshua N. Farr, Paul D. Robbins, Sundeep Khosla
Publikováno v:
bioRxiv
In addition to reducing fracture risk, zoledronate has been found in some studies to decrease mortality in humans and extend lifespan and healthspan in animals. Because senescent cells accumulate with aging and contribute to multiple co-morbidities,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::860b17e11361e17f64c5c23f10ba8b50
https://europepmc.org/articles/PMC9980119/
https://europepmc.org/articles/PMC9980119/