A Single Nucleotide Polymorphism in Human APOBEC3C Enhances Restriction of Lentiviruses.

Autor: Cristina J Wittkopp, Madison B Adolph, Lily I Wu, Linda Chelico, Michael Emerman

Publikováno v: PLoS Pathogens, Vol 12, Iss 10, p e1005865 (2016)

Humans express seven human APOBEC3 proteins, which can inhibit viruses and endogenous retroelements through cytidine deaminase activity. The seven paralogs differ in the potency of their antiviral effects, as well as in their antiviral targets. One A

Externí odkaz: https://doaj.org/article/8c1ebe9e16a6497285fc401a3c48e6d0

The DNA cytosine deaminase APOBEC3H haplotype I likely contributes to breast and lung cancer mutagenesis

Autor: Gabriel J. Starrett, Elizabeth M. Luengas, Jennifer L. McCann, Diako Ebrahimi, Nuri A. Temiz, Robin P. Love, Yuqing Feng, Madison B. Adolph, Linda Chelico, Emily K. Law, Michael A. Carpenter, Reuben S Harris

Publikováno v: Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)

The APOBEC family of enzymes are cytidine deaminases with APOBEC3A and APOBEC3B thought to contribute to DNA damage signatures detected in cancer genomes. Here, the authors demonstrate an unappreciated role for APOBEC3H haplotype I in the generation

Externí odkaz: https://doaj.org/article/341af74da85247c89f420036391ce4bf

RADX controls RAD51 filament dynamics to regulate replication fork stability

Autor: Florian Morati, Madison B. Adolph, Chaoyou Xue, Eric C. Greene, Swati Balakrishnan, Walter J. Chazin, Taha M. Mohamed, David Cortez, Mauro Modesti

Publikováno v: Molecular Cell
Molecular Cell, Elsevier, 2021, 81 (5), pp.1074-1083.e5. ⟨10.1016/j.molcel.2020.12.036⟩
Mol Cell
Molecular Cell, 2021, 81 (5), pp.1074-1083.e5. ⟨10.1016/j.molcel.2020.12.036⟩

The RAD51 recombinase forms nucleoprotein filaments to promote double-strand break repair, replication fork reversal, and fork stabilization. The stability of these filaments is highly regulated since both too little and too much RAD51 activity can c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5c5b95b3ec381eed0bcd2c15d461636
https://hal-amu.archives-ouvertes.fr/hal-03438611

APOBEC3 enzymes mediate efficacy of cisplatin and are epistatic with base excision repair and mismatch repair in platinum response

Autor: Linda Chelico, Seongho Kim, Kayla L. Conner, Ashley M. Floyd, Michele L. Cote, Wen Lei, Jacob Lindquist, Steve M. Patrick, Akshada Sawant, Ashok S. Bhagwat, Asra N. Shaik, Madison B. Adolph, Sachini U. Siriwardena, Katie A Marshall, Elmira Ekinci

Publikováno v: Nar Cancer

Identifying the mechanisms mediating cisplatin response is essential for improving patient response. Previous research has identified base excision repair (BER) and mismatch repair (MMR) activity in sensitizing cells to cisplatin. Cisplatin forms DNA

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f68c914ae47b3521bbcc03538c65f37
https://doi.org/10.1093/narcan/zcaa033

APOBEC3 Host Restriction Factors of HIV-1 Can Change the Template Switching Frequency of Reverse Transcriptase

Autor: Anjuman Ara, Madison B. Adolph, Linda Chelico

Publikováno v: Journal of molecular biology. 431(7)

The APOBEC3 family of deoxycytidine deaminases has the ability to restrict HIV-1 through deamination-dependent and deamination-independent mechanisms. Although the generation of mutations through deamination of cytosine to uracil in single-stranded H

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a020d0ccd6689b1b7a54ade1516f0af3
https://pubmed.ncbi.nlm.nih.gov/30797859