Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Madison B Adolph"'
Autor:
Gabriel J. Starrett, Elizabeth M. Luengas, Jennifer L. McCann, Diako Ebrahimi, Nuri A. Temiz, Robin P. Love, Yuqing Feng, Madison B. Adolph, Linda Chelico, Emily K. Law, Michael A. Carpenter, Reuben S Harris
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
The APOBEC family of enzymes are cytidine deaminases with APOBEC3A and APOBEC3B thought to contribute to DNA damage signatures detected in cancer genomes. Here, the authors demonstrate an unappreciated role for APOBEC3H haplotype I in the generation
Externí odkaz:
https://doaj.org/article/341af74da85247c89f420036391ce4bf
Publikováno v:
PLoS Pathogens, Vol 12, Iss 10, p e1005865 (2016)
Humans express seven human APOBEC3 proteins, which can inhibit viruses and endogenous retroelements through cytidine deaminase activity. The seven paralogs differ in the potency of their antiviral effects, as well as in their antiviral targets. One A
Externí odkaz:
https://doaj.org/article/8c1ebe9e16a6497285fc401a3c48e6d0
Autor:
Madison B. Adolph, Robin P. Love, Nazanin Mohammadzadeh, Linda Chelico, Louis M. Mansky, Yumeng Z McDaniel, Dake Wang
Publikováno v:
Nucleic Acids Research
The human apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3 (APOBEC3, A3) family member proteins can deaminate cytosines in single-strand (ss) DNA, which restricts human immunodeficiency virus type 1 (HIV-1), retrotransposons, and ot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9672ab12e554dab6beb84f49d5cceda5
http://europepmc.org/articles/PMC7026630
http://europepmc.org/articles/PMC7026630
Autor:
Florian Morati, Madison B. Adolph, Chaoyou Xue, Eric C. Greene, Swati Balakrishnan, Walter J. Chazin, Taha M. Mohamed, David Cortez, Mauro Modesti
Publikováno v:
Molecular Cell
Molecular Cell, Elsevier, 2021, 81 (5), pp.1074-1083.e5. ⟨10.1016/j.molcel.2020.12.036⟩
Mol Cell
Molecular Cell, 2021, 81 (5), pp.1074-1083.e5. ⟨10.1016/j.molcel.2020.12.036⟩
Molecular Cell, Elsevier, 2021, 81 (5), pp.1074-1083.e5. ⟨10.1016/j.molcel.2020.12.036⟩
Mol Cell
Molecular Cell, 2021, 81 (5), pp.1074-1083.e5. ⟨10.1016/j.molcel.2020.12.036⟩
The RAD51 recombinase forms nucleoprotein filaments to promote double-strand break repair, replication fork reversal, and fork stabilization. The stability of these filaments is highly regulated since both too little and too much RAD51 activity can c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5c5b95b3ec381eed0bcd2c15d461636
https://hal-amu.archives-ouvertes.fr/hal-03438611
https://hal-amu.archives-ouvertes.fr/hal-03438611
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e64196 (2013)
It is well established that the cytosine deaminase APOBEC3G can restrict HIV-1 virions in the absence of the virion infectivity factor (Vif) by inducing genome mutagenesis through deamination of cytosine to uracil in single-stranded HIV-1 (-)DNA. How
Externí odkaz:
https://doaj.org/article/de0677f8b0f3425085cb01f5f2feef30
Autor:
Linda Chelico, Seongho Kim, Kayla L. Conner, Ashley M. Floyd, Michele L. Cote, Wen Lei, Jacob Lindquist, Steve M. Patrick, Akshada Sawant, Ashok S. Bhagwat, Asra N. Shaik, Madison B. Adolph, Sachini U. Siriwardena, Katie A Marshall, Elmira Ekinci
Publikováno v:
Nar Cancer
Identifying the mechanisms mediating cisplatin response is essential for improving patient response. Previous research has identified base excision repair (BER) and mismatch repair (MMR) activity in sensitizing cells to cisplatin. Cisplatin forms DNA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f68c914ae47b3521bbcc03538c65f37
https://doi.org/10.1093/narcan/zcaa033
https://doi.org/10.1093/narcan/zcaa033
Publikováno v:
Journal of Biological Chemistry. 298:101672
Genome integrity requires complete and accurate DNA replication once per cell division cycle. Replication stress poses obstacles to this process that must be overcome to prevent replication fork collapse. An important regulator of replication fork st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cae514c002b877541df19e51f32163a0
https://doi.org/10.1016/j.jbc.2022.101672
https://doi.org/10.1016/j.jbc.2022.101672
Autor:
Madison B. Adolph, David Cortez, Alessandro Vindigni, Jessica Jackson, Taha M. Mohamed, Archana Krishnamoorthy
Publikováno v:
Mol Cell
RAD51 facilitates replication fork reversal and protects reversed forks from nuclease degradation. Although potentially a useful replication stress response mechanism, unregulated fork reversal can cause genome instability. Here we show that RADX, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30f31abb2e9f8e27bf64b55bc0739ed4
https://doi.org/10.1016/j.molcel.2021.05.014
https://doi.org/10.1016/j.molcel.2021.05.014
Publikováno v:
Journal of molecular biology. 431(7)
The APOBEC3 family of deoxycytidine deaminases has the ability to restrict HIV-1 through deamination-dependent and deamination-independent mechanisms. Although the generation of mutations through deamination of cytosine to uracil in single-stranded H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a020d0ccd6689b1b7a54ade1516f0af3
https://pubmed.ncbi.nlm.nih.gov/30797859
https://pubmed.ncbi.nlm.nih.gov/30797859
Publikováno v:
ACS infectious diseases. 4(3)
The Apolipoprotein B mRNA editing complex (APOBEC) family of enzymes contains single-stranded polynucleotide cytidine deaminases. These enzymes catalyze the deamination of cytidine in RNA or single-stranded DNA, which forms uracil. From this 11 membe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1699cd4775b63ff4d987f2172fd169e5
https://pubmed.ncbi.nlm.nih.gov/29347817
https://pubmed.ncbi.nlm.nih.gov/29347817