Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Madina R. Gerasimov"'
Autor:
Andrew N. Gifford, Dianne E. Lee, Madina R. Gerasimov, Robert L. Balster, Lauren Collier, Abbie Ferrieri, David Alexoff
Publikováno v:
European Journal of Pharmacology. 477:45-52
Toluene is a widely abused solvent with demonstrated addictive potential in humans. Here we explore if conditioned place preference can be used to study the abuse-related effects of inhaled toluene in rats. Animals were confined to a distinctive comp
Autor:
Madina R. Gerasimov, C. L. Woody, Joanna S. Fowler, Paul Vaska, Stephen L. Dewey, David J. Schlyer, Nora D. Volkow, S. P. Stoll, S. Shokouhi
Publikováno v:
IEEE Transactions on Nuclear Science. 49:2208-2212
Several types of scintillation microprobes have recently been developed to directly measure positron activity from radiotracers in live animals. These probes consist of either a small lutetium oxyorthosilicate (LSO) crystal or plastic scintillator co
Autor:
Richard A. Ferrieri, David Alexoff, Stephen L. Dewey, Jean Logan, Ryan D Muller, Madina R. Gerasimov
Publikováno v:
Nuclear Medicine and Biology. 29:607-612
With the goal of investigating the pharmacokinetics of the abused solvent, toluene we have adapted the rapid coupling of methyl iodide with tributylphenylstannane mediated by palladium(0) complex to the synthesis of no-carrier-added [ 11 C]toluene st
Publikováno v:
Nuclear Medicine and Biology. 29:351-357
Abuse of inhalants in today’s society has become such a widespread problem among today’s adolescents that in many parts of the world their use exceeds that of many other illicit drugs or alcohol. Even so, little is known how such inhalants affect
Autor:
Charles R. Ashby, Samuel J. Gatley, Andrew N. Gifford, Madina R. Gerasimov, Stephen L. Dewey, Wynne K. Schiffer, Pauline Carter, David Alexoff, Stephen A. Vitkun, Colleen Shea, Payton King, Victor Garza, Douglas A. Marsteller, Jean Logan, Richard A. Ferrieri
Publikováno v:
Life Sciences. 70:2811-2828
Inhalant abuse is a rapidly growing health problem particularly among adolescents. Yet we know little about the neural mechanisms underlying the abuse liability of inhalants, particularly when compared to other addictive drugs. Specifically, our unde
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 45:199-211
γ-Vinyl-γ-aminobutyric acid (GVG, Vigabatrin®), a suicide inhibitor of GABA-transaminase (GABA-T), has been suggested as a new drug for the treatment of substance abuse. In order to better understand its pharmacokinetics and potential side effects
Autor:
Madina R. Gerasimov, Wynne K. Schiffer, Stephen L. Dewey, Charles R. Ashby, Lauren Hofmann, David Alexoff, Douglas A. Marsteller, Jonathan D. Brodie
Publikováno v:
Neuropsychopharmacology. 25:704-712
To explore the role of endogenous GABA in NMDA antagonist induced dopamine (DA) release, we used in vivo microdialysis to study the effects of pretreatment with gamma-vinyl GABA (GVG) on phencyclidine (PCP)-induced DA release in terminal regions of m
Autor:
Stephen L. Dewey, Stephen J.C Taylor, Madina R. Gerasimov, Wynne K. Schiffer, J. D. Brodie, Ian C Lennon
Publikováno v:
European Journal of Pharmacology. 395:129-135
Dopaminergic activity in the mesocorticolimbic system is associated with reinforcing properties of psychostimulant drugs. We previously demonstrated that increased γ-aminobutyric acid (GABA)-ergic activity produced by γ-vinyl GABA [ d , l -4-amino-
Publikováno v:
Life Sciences. 66:PL169-PL173
Elevation of endogenous GABA by the racemic mixture of gamma vinyl-GABA (GVG, Vigabatrin®) decreases extracellular nucleus accumbens (NAc) dopamine (DA) levels and diminishes the response to many drugs of abuse known to elevate DA in the mesocortico
Autor:
Maja Franceschi, Madina R. Gerasimov, Wynne K. Schiffer, Onarae V. Rice, Stephen L. Dewey, Nora D. Volkow
Publikováno v:
Synapse. 38:432-437
There is a greater prevalence of cigarette smoking among cocaine- dependent individuals and hyperactive children treated with stimulants (e.g., methyl- phenidate, MP). However, little is known about the neurochemical basis of the interac- tion betwee