Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Madhwesh C Ravichandran"'
Autor:
Venu Thatikonda, Verena Supper, Johannes Wachter, Onur Kaya, Anju Kombara, Ceren Bilgilier, Madhwesh C. Ravichandran, Jesse J. Lipp, Rahul Sharma, Lukas Badertscher, Andrew S. Boghossian, Matthew G. Rees, Melissa M. Ronan, Jennifer A. Roth, Sarah Grosche, Ralph A. Neumüller, Barbara Mair, Federico Mauri, Alexandra Popa
Publikováno v:
Cell Reports, Vol 43, Iss 5, Pp 114175- (2024)
Summary: Transcription factors (TFs) are important mediators of aberrant transcriptional programs in cancer cells. In this study, we focus on TF activity (TFa) as a biomarker for cell-line-selective anti-proliferative effects, in that high TFa predic
Externí odkaz:
https://doaj.org/article/cf2194b70a344373b2d1a869bceef1a4
Autor:
Venu Thatikonda, Verena Supper, Madhwesh C. Ravichandran, Jesse J. Lipp, Andrew S. Boghossian, Matthew G. Rees, Melissa M. Ronan, Jennifer A. Roth, Sara Grosche, Ralph A. Neumüller, Barbara Mair, Federico Mauri, Alexandra Popa
Transcription factors (TFs) are key components of the aberrant transcriptional programs in cancer cells. In this study, we used TF activity (TFa), inferred from the downstream regulons as a potential biomarker to identify associated genetic vulnerabi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::49167a733aa3def504d91a1b261f0825
https://doi.org/10.1101/2023.02.23.529701
https://doi.org/10.1101/2023.02.23.529701
Autor:
Matthew N Clarke, Theodor Marsoner, Manuel Alonso Y Adell, Madhwesh C Ravichandran, Christopher S Campbell
Publikováno v:
The EMBO Journal. 42
Both an increased frequency of chromosome missegregation (chromosomal instability, CIN) and the presence of an abnormal complement of chromosomes (aneuploidy) are hallmarks of cancer. To better understand how cells are able to adapt to high levels of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35bbd4fa060d67e130fd15173e0831fe
https://doi.org/10.15252/embj.2022111500
https://doi.org/10.15252/embj.2022111500
Autor:
Matthew N. Clarke, Theodor Marsoner, Manuel Alonso Y Adell, Madhwesh C. Ravichandran, Christopher S. Campbell
Both an increased frequency of chromosome missegregation (chromosomal instability) and the presence of an abnormal complement of chromosomes (aneuploidy) are hallmarks of cancer. Paradoxically, both chromosomal instability and aneuploidy are also ass
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5d741bf2701d5e991e775efddf4e1840
https://doi.org/10.1101/2022.04.21.489003
https://doi.org/10.1101/2022.04.21.489003
Autor:
Anna Köferle, Andreas Schlattl, Alexandra Hörmann, Fiona Spreitzer, Alexandra Popa, Venu Thatikonda, Teresa Puchner, Verena Supper, Madhwesh C. Ravichandran, Sarah Oberndorfer, Corinna Wieshofer, Maja Corcokovic, Christoph Reiser, Simon Wöhrle, Johannes Popow, Mark Pearson, Barbara Mair, Ralph A. Neumüller
Publikováno v:
Cancer Research. 82:4004-4004
Genetic networks are characterized by extensive buffering. During tumor evolution, disruption of these functional redundancies can create de novo vulnerabilities that are specific to cancer cells. In this regard, paralog genes are of particular inter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eef1d7607419cdd22e074905dbf74f20
https://doi.org/10.1158/1538-7445.am2022-4004
https://doi.org/10.1158/1538-7445.am2022-4004
Autor:
Anna Köferle, Andreas Schlattl, Alexandra Hörmann, Venu Thatikonda, Alexandra Popa, Fiona Spreitzer, Madhwesh C. Ravichandran, Verena Supper, Sarah Oberndorfer, Teresa Puchner, Corinna Wieshofer, Maja Corcokovic, Christoph Reiser, Simon Wöhrle, Johannes Popow, Mark Pearson, Javier Martinez, Stefan Weitzer, Barbara Mair, Ralph A. Neumüller
Publikováno v:
Cell Reports. 39:110636
Genetic networks are characterized by extensive buffering. During tumor evolution, disruption of functional redundancies can create de novo vulnerabilities that are specific to cancer cells. Here, we systematically search for cancer-relevant paralog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba2bb486e7a7e4103639150fed5c4db8
https://doi.org/10.1016/j.celrep.2022.110636
https://doi.org/10.1016/j.celrep.2022.110636
Autor:
J.A. Newman, Katja Hauer, Klaus Rumpel, Opher Gileadi, Patrick Werni, Madhwesh C Ravichandran, Angeline E Gavard, John R. Engen, Jark Böttcher, Simone Lieb, Leonhard Geist, Mark Petronczki, Matthias Samwer
Publikováno v:
Life Science Alliance
WRN is a key drug target for cancers with microsatellite instability. A crystal structure of the helicase domain of WRN identifies its unique features and provides a basis for structure-guided design of inhibitors.
Loss of WRN, a DNA repair heli
Loss of WRN, a DNA repair heli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8537331a31ae7f2dac10e861eafb5cae
https://doi.org/10.26508/lsa.202000795
https://doi.org/10.26508/lsa.202000795