Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Madhushika Ratnayake"'
Autor:
Madhushika Ratnayake, Maria Tselepi, Robert Bloxham, Frank Plöger, Louise N Reynard, John Loughlin
Publikováno v:
PLoS ONE, Vol 12, Iss 5, p e0176523 (2017)
Osteoarthritis (OA) is a common joint disease characterised by the focal loss of the protective cartilage layer at the ends of the bones. It is painful, disabling, multifactorial and polygenic. The growth differentiation factor 5 gene GDF5 was one of
Externí odkaz:
https://doaj.org/article/d79d26bc93634509b282c10bbb86e9cc
Publikováno v:
PLoS ONE, Vol 11, Iss 7, p e0159024 (2016)
The single nucleotide polymorphism (SNP) rs835487 is associated with hip osteoarthritis (OA) at the genome-wide significance level and is located within CHST11, which codes for carbohydrate sulfotransferase 11. This enzyme post-translationally modifi
Externí odkaz:
https://doaj.org/article/481312e702cb440dac5f62a3b298f550
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e86590 (2014)
A genetic deficit mediated by SNP rs143383 that leads to reduced expression of GDF5 is strongly associated with large-joint osteoarthritis. We speculated that this deficit could be attenuated by the application of exogenous GDF5 protein and as a firs
Externí odkaz:
https://doaj.org/article/40a72ee6bd1a4c28b313a5976a8f96b2
Autor:
Konstantinos, Hatzikotoulas, Andreas, Roposch, Karan M, Shah, Matthew J, Clark, Selina, Bratherton, Vasanti, Limbani, Julia, Steinberg, Eleni, Zengini, Kaltuun, Warsame, Madhushika, Ratnayake, Maria, Tselepi, Jeremy, Schwartzentruber, John, Loughlin, Deborah M, Eastwood, Eleftheria, Zeggini, Manoj, Ramachandran
Publikováno v:
Communications biology. 1
Developmental dysplasia of the hip (DDH) is the most common skeletal developmental disease. However, its genetic architecture is poorly understood. We conduct the largest DDH genome-wide association study to date and replicate our findings in indepen
Autor:
Selina Bratherton, Jeremy Mark Wilkinson, Eleftheria Zeggini, Julia Steinberg, Eleni Zengini, M. Tselepi, Andreas Roposch, Madhushika Ratnayake, M.J. Clark, Vasanti Limbani, Kaltuun Warsame, Konstantinos Hatzikotoulas, Jeremy Schwartzentruber, Karan M. Shah, John Loughlin, Deborah M. Eastwood, Wilkinson Jm
Background: Developmental dysplasia of the hip (DDH) is a common, heritable condition characterised by abnormal formation of the hip joint, but has a poorly understood genetic architecture due to small sample sizes. We apply a novel case-ascertainmen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfc7efd86c806148d7df52f44e648bb1
Autor:
Madhushika Ratnayake, Maria Tselepi, Robert Bloxham, Frank Plöger, Louise N Reynard, John Loughlin
Publikováno v:
PLoS ONE
PLoS ONE, Vol 12, Iss 5, p e0176523 (2017)
PLoS ONE, Vol 12, Iss 5, p e0176523 (2017)
Osteoarthritis (OA) is a common joint disease characterised by the focal loss of the protective cartilage layer at the ends of the bones. It is painful, disabling, multifactorial and polygenic. The growth differentiation factor 5 gene GDF5 was one of
Autor:
Shin S-Y., Steffan D. Bos, Margreet Kloppenburg, Andres Metspalu, Ashok Rai, Karen E. Chapman, Tõnu Esko, J M Willkinson, Panagiotis Deloukas, Gudmar Thorleifsson, Nigel K Arden, Ingileif Jonsdottir, Andrew Carr, Kalliope Panoutsopoulou, Fernando Rivadeneira, Michelle Ricketts, F O'Neill, Sarah Metrustry, Massimo Mangino, Ollier Wer., Sarah E. Hunt, N Koller, Sally Doherty, M C Lopes, John Loughlin, Raine Eva., Andrew McCaskie, Bridget Watkins, Lorraine Southam, Gillian A. Wallis, Battley P-K., Vijay K. Yadav, U Stykarsdottir, N Aslam, Evangelos Evangelou, van Meurs Jbj., K Walker, Donald Salter, Mike R. Reed, K. Stefansson, I Carluke, E Arden, K Sherburn, Stuart Ralston, Tim D. Spector, Suzannah Bumpstead, Madhushika Ratnayake, Hannah Blackburn, K S Elliott, H Jonnson, Guangju Zhai, Michael Doherty, M. Wheeler, Thorvaldur Ingvarsson, Ingrid Meulenbelt, J Joseph, Fraser Birrell, D Swift, A.G. Uitterlinden, K Dixon, Ioannidis Jpa., Hanneke J. M. Kerkhof, Aaron G. Day-Williams, E Paling, Simon C. Potter, Ana M. Valdes, P E Slagboom, Richard Keen, Sheryl Mitchell, C Beazley, Eleftheria Zeggini, A Hoffman, Vesna Boraska, Jeanine J. Houwing-Duistermaat, Allan Gordon, N W Rayner
Publikováno v:
Lancet
Zeggini, E, Panoutsopoulou, K, Southam, L, Rayner, N W, Day-Williams, A G, Lopes, M C, Boraska, V, Esko, T, Evangelou, E, Hofman, A, Houwing-Duistermaat, J J, Ingvarsson, T, Jonsdottir, I, Jonsson, H, Kerkhof, H J M, Kloppenburg, M, Bos, S D, Mangino, M, Metrustry, S, Slagboom, P E, Thorleifsson, G, Raine, E V A, Ratnayake, M, Ricketts, M, Beazley, C, Blackburn, H, Bumpstead, S, Elliott, K S, Hunt, S E, Potter, S C, Shin, S-Y, Yadav, V K, Zhai, G, Sherburn, K, Dixon, K, Arden, E, Aslam, N, Battley, P-K, Carluke, I, Doherty, S, Gordon, A, Joseph, J, Keen, R, Koller, N C, Mitchell, S, O'Neill, F, Paling, E, Reed, M R & Salter, D & Ralston, S H 2012, ' Identification of new susceptibility loci for osteoarthritis (arcOGEN) : a genome-wide association study ', The Lancet, vol. 380, no. 9844, pp. 815-823 . https://doi.org/10.1016/S0140-6736(12)60681-3
The Lancet; Vol 380
Zeggini, E, Panoutsopoulou, K, Southam, L, Rayner, N W, Day-Williams, A G, Lopes, M C, Boraska, V, Esko, T, Evangelou, E, Hofman, A, Houwing-Duistermaat, J J, Ingvarsson, T, Jonsdottir, I, Jonsson, H, Kerkhof, H J M, Kloppenburg, M, Bos, S D, Mangino, M, Metrustry, S, Slagboom, P E, Thorleifsson, G, Raine, E V A, Ratnayake, M, Ricketts, M, Beazley, C, Blackburn, H, Bumpstead, S, Elliott, K S, Hunt, S E, Potter, S C, Shin, S-Y, Yadav, V K, Zhai, G, Sherburn, K, Dixon, K, Arden, E, Aslam, N, Battley, P-K, Carluke, I, Doherty, S, Gordon, A, Joseph, J, Keen, R, Koller, N C, Mitchell, S, O'Neill, F, Paling, E, Reed, M R & Salter, D & Ralston, S H 2012, ' Identification of new susceptibility loci for osteoarthritis (arcOGEN) : a genome-wide association study ', The Lancet, vol. 380, no. 9844, pp. 815-823 . https://doi.org/10.1016/S0140-6736(12)60681-3
The Lancet; Vol 380
BACKGROUND: Osteoarthritis is the most common form of arthritis worldwide and is a major cause of pain and disability in elderly people. The health economic burden of osteoarthritis is increasing commensurate with obesity prevalence and longevity. Os
Publikováno v:
Osteoarthritis and Cartilage. 24:S463-S464
Publikováno v:
PLoS ONE
PLoS ONE; Vol 9
PLoS ONE, Vol 9, Iss 1, p e86590 (2014)
PLoS ONE; Vol 9
PLoS ONE, Vol 9, Iss 1, p e86590 (2014)
A genetic deficit mediated by SNP rs143383 that leads to reduced expression of GDF5 is strongly associated with large-joint osteoarthritis. We speculated that this deficit could be attenuated by the application of exogenous GDF5 protein and as a firs
Publikováno v:
BMC Medical Genetics, Vol 13, Iss 1, p 12 (2012)
BMC Medical Genetics
BMC Medical Genetics
Background A genome-wide association scan with subsequent replication study that involved over 67,000 individuals of European ancestry has produced evidence of association of single nucleotide polymorphism rs2277831 to primary osteoarthritis (OA) wit