Výsledky vyhledávání - "Madhumita Pradhan"

Data from Positive Cross-Talk between Estrogen Receptor and NF-κB in Breast Cancer

Autor: Adina Stanculescu, Chin-Yo Lin, Lance D. Miller, Yang Dai, Madhumita Pradhan, Aisha Weaver, Jonna Frasor

Estrogen receptors (ER) and nuclear factor-κB (NF-κB) are known to play important roles in breast cancer, but these factors are generally thought to repress each other's activity. However, we have recently found that ER and NF-κB can also act toge

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f633532738da3e0bfc905725dc59047b
https://doi.org/10.1158/0008-5472.c.6500480

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A Kinase-Independent Activity of Cdk9 Modulates Glucocorticoid Receptor-Mediated Gene Induction

Autor: Geoffrey B. Storchan, S. Stoney Simons, Rong Zhu, Carson C. Chow, Stephen P. Armstrong, Xinping Lu, Madhumita Pradhan

Publikováno v: Biochemistry

A gene induction competition assay has recently uncovered new inhibitory activities of two transcriptional cofactors, NELF-A and NELF-B, in glucocorticoid-regulated transactivation. NELF-A and -B are also components of the NELF complex, which partici

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08eb8244407f4d22f5019b5bcb060a8e
http://europepmc.org/articles/PMC3985961

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CBP Mediates NF-κB-Dependent Histone Acetylation and Estrogen Receptor Recruitment to an Estrogen Response Element in the BIRC3 Promoter

Autor: Jonna Frasor, Leslie A. Bembinster, Sarah C. Baumgarten, Madhumita Pradhan

Publikováno v: Molecular and Cellular Biology. 32:569-575

Estrogen receptor (ER) and NF-κB are transcription factors with profound effects on breast cancer cell proliferation and survival. While many studies demonstrate that ER and NF-κB can repress each other, we previously identified a gene signature th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc3c54f1e761870f714249570c6f3d9b
https://doi.org/10.1128/mcb.05869-11

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Positive Cross-Talk between Estrogen Receptor and NF-κB in Breast Cancer

Autor: Aisha E. Weaver, Lance D. Miller, Yang Dai, Chin-Yo Lin, Madhumita Pradhan, Jonna Frasor, Adina Stanculescu

Publikováno v: Cancer Research. 69:8918-8925

Estrogen receptors (ER) and nuclear factor-kappaB (NF-kappaB) are known to play important roles in breast cancer, but these factors are generally thought to repress each other's activity. However, we have recently found that ER and NF-kappaB can also

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a824fba017a8dd0317fc2ccc032858cb
https://doi.org/10.1158/0008-5472.can-09-2608

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Kinetically Defined Mechanisms and Positions of Action of Two New Modulators of Glucocorticoid Receptor-regulated Gene Induction*

Autor: S. Stoney Simons, Dinah S. Singer, Madhumita Pradhan, Petria S. Thompson, Carson C. Chow, Ballachanda N. Devaiah, John A. Blackford

Most of the steps in, and many of the factors contributing to, glucocorticoid receptor (GR)-regulated gene induction are currently unknown. A competition assay, based on a validated chemical kinetic model of steroid hormone action, is now used to ide

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b16ca8322ba78f7dee18a401e23b713
https://europepmc.org/articles/PMC4697169/

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Research resource: modulators of glucocorticoid receptor activity identified by a new high-throughput screening assay

Autor: Zhuyin Li, Christopher P. Austin, John A. Blackford, S. Stoney Simons, Carson C. Chow, Madhumita Pradhan, Edward J. Dougherty, Kyle R. Brimacombe, Min Shen, Douglas S. Auld

Publikováno v: Molecular endocrinology (Baltimore, Md.). 28(7)

Glucocorticoid steroids affect almost every type of tissue and thus are widely used to treat a variety of human pathological conditions. However, the severity of numerous side effects limits the frequency and duration of glucocorticoid treatments. Of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49d6697abfc4d0432b57d158d5a7b694
https://pubmed.ncbi.nlm.nih.gov/24850414

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Proinflammatory cytokines enhance estrogen-dependent expression of the multidrug transporter gene ABCG2 through estrogen receptor and NF{kappa}B cooperativity at adjacent response elements

Autor: Sarah C. Baumgarten, Leslie A. Bembinster, Madhumita Pradhan, Jonna Frasor

Publikováno v: The Journal of biological chemistry. 285(41)

Constitutive activation of NFκB in estrogen receptor (ER)-positive breast cancer is associated with tumor recurrence and development of anti-estrogen resistance. Furthermore, a gene expression signature containing common targets for ER and NFκB has

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::065cd1db2ea02ce8fd22e967483eae73
https://pubmed.ncbi.nlm.nih.gov/20705611

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Synergistic Up-Regulation of Prostaglandin E Synthase Expression in Breast Cancer Cells by 17β-Estradiol and Proinflammatory Cytokines

Autor: Aisha E. Weaver, Kinnari Mehta, Madhumita Pradhan, Jonna Frasor

Inflammatory mediators, such as cytokines and prostaglandins, play a fundamental role in estrogen-dependent breast cancer through their ability to up-regulate aromatase expression and subsequent local production of estrogens in the breast. To study t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5aab333a971d4212ecc3af250026afb1
https://europepmc.org/articles/PMC6285349/

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