Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Madhulika Tripathi"'
Autor:
Reddemma Sandireddy, Suganya Sakthivel, Priyanka Gupta, Jatin Behari, Madhulika Tripathi, Brijesh Kumar Singh
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 12 (2024)
Metabolic dysfunction-associated steatotic liver disease (MASLD), previously known as non-alcoholic fatty liver disease (NAFLD), is the most common liver disorder worldwide, with an estimated global prevalence of more than 31%. Metabolic dysfunction-
Externí odkaz:
https://doaj.org/article/2743a4cc294e4557961a319afae5bacc
Autor:
Jin Zhou, Jeremy Pang, Madhulika Tripathi, Jia Pei Ho, Anissa Anindya Widjaja, Shamini Guna Shekeran, Stuart Alexander Cook, Ayako Suzuki, Anna Mae Diehl, Enrico Petretto, Brijesh Kumar Singh, Paul Michael Yen
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Spermidine, a polyamine reported to extend lifespan and reduce the risk of age-related diseases, serves as a substrate for the post-translational modification hypusination. Here the authors report that EIF5A hypusination, which regulates mitochondria
Externí odkaz:
https://doaj.org/article/27de688eb5a24929b14771a4cd8acfce
Autor:
Jinrui Dong, Sivakumar Viswanathan, Eleonora Adami, Brijesh K. Singh, Sonia P. Chothani, Benjamin Ng, Wei Wen Lim, Jin Zhou, Madhulika Tripathi, Nicole S. J. Ko, Shamini G. Shekeran, Jessie Tan, Sze Yun Lim, Mao Wang, Pei Min Lio, Paul M. Yen, Sebastian Schafer, Stuart A. Cook, Anissa A. Widjaja
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
IL11 contributes to the development of non-alcoholic steatohepatitis (NASH) through incompletely understood mechanisms. Here, the authors report that lipotoxicity-driven autocrine IL11 activity underlies hepatocyte metabolic dysfunction and death via
Externí odkaz:
https://doaj.org/article/ce2b5ee017d5453ea86274564e8eb24f
Autor:
Eveline Bruinstroop, Jin Zhou, Madhulika Tripathi, Winifred W. Yau, Anita Boelen, Brijesh Kumar Singh, Paul M. Yen
Publikováno v:
Molecular Metabolism, Vol 53, Iss , Pp 101266- (2021)
Objective: Nonalcoholic fatty liver disease (NAFLD) comprises a spectrum ranging from hepatosteatosis to progressive nonalcoholic steatohepatitis that can lead to cirrhosis. Humans with low levels of prohormone thyroxine (T4) have a higher incidence
Externí odkaz:
https://doaj.org/article/d879531f2fef46d28ca34500556eedee
Publikováno v:
STAR Protocols, Vol 1, Iss 2, Pp 100064- (2020)
Summary: Previously developed senescent primary fibroblast models have limited relevance to study age-related changes in metabolically active tissues such as the liver. Here, we describe a protocol to generate senescent cells from the mouse hepatic c
Externí odkaz:
https://doaj.org/article/e6ee686542c84003b84e890e1d30daf6
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 5, p 1645 (2020)
The estrogen-related receptor alpha (ESRRA) is an orphan nuclear receptor (NR) that significantly influences cellular metabolism. ESRRA is predominantly expressed in metabolically-active tissues and regulates the transcription of metabolic genes, inc
Externí odkaz:
https://doaj.org/article/d6402862b1cf47eb9ca5025774568788
Autor:
Radhika Kapoor, Shruti Singh, Madhulika Tripathi, Priyanka Bhatnagar, Poonam Kakkar, Kailash Chand Gupta
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e89124 (2014)
Nanotized phytochemicals are being explored by researchers for promoting their uptake and effectiveness at lower concentrations. In this study, O-hexadecyl-dextran entrapped berberine chloride nanoparticles (BC-HDD NPs) were prepared, and evaluated f
Externí odkaz:
https://doaj.org/article/00ff19613dea4e0789a4710e63940ff9
Publikováno v:
PLoS ONE, Vol 7, Iss 4, p e34200 (2012)
Nimesulide, an anti-inflammatory and analgesic drug, is reported to cause severe hepatotoxicity. In this study, molecular mechanisms involved in deranged oxidant-antioxidant homeostasis and mitochondrial dysfunction during nimesulide-induced hepatoto
Externí odkaz:
https://doaj.org/article/faff0610c9204187a1bb9b2e672306e0
Autor:
Madhulika Tripathi1 singhbrijeshk@duke-nus.edu.sg, Singh, Brijesh Kumar1 madhulika.tripathi@duke-nus.edu.sg
Publikováno v:
FEBS Journal. Mar2023, Vol. 290 Issue 6, p1473-1476. 4p.
Autor:
Madhulika Tripathi, Brijesh Kumar Singh, Jin Zhou, Keziah Tikno, Anissa Widjaja, Reddemma Sandireddy, Kabilesh Arul, Siti Aishah Binte Abdul Ghani, George Goh Boon Bee, Kiraely Adam Wong, Ho Jia Pei, Shamini Guna Shekeran, Rohit Anthony Sinha, Manvendra K. Singh, Stuart Alexander Cook, Ayako Suzuki, Teegan Reina Lim, Chang-Chuen Cheah, Jue Wang, Rui-Ping Xiao, Xiuqing Zhang, Pierce Kah Hoe Chow, Paul Michael Yen
Publikováno v:
Journal of Hepatology. 77:1246-1255