Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Madhu Sudan Manna"'
Autor:
Madhu Sudan Manna, Yusuf Talha Tamer, Ilona Gaszek, Nicole Poulides, Ayesha Ahmed, Xiaoyu Wang, Furkan C. R. Toprak, DaNae R. Woodard, Andrew Y. Koh, Noelle S. Williams, Dominika Borek, Ali Rana Atilgan, John D. Hulleman, Canan Atilgan, Uttam Tambar, Erdal Toprak
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
The efficacy of the antibiotic trimethoprim, which inhibits bacterial dihydrofolate reductase (DHFR), is limited by the rapid emergence of resistant bacteria. Here, Manna et al. show that 4’-desmethyltrimethoprim inhibits DHFR and a common TMP-resi
Externí odkaz:
https://doaj.org/article/0c5515c73c4846e48b35aa04d428f118
Autor:
Jennifer S. Hirschi, Madhu Sudan Manna, Sharath Chandra Mallojjala, Santanu Mukherjee, Rahul Sakar, Rachael W. Karugu
Experimental 13C kinetic isotope effects (KIEs) and DFT calculations are used to evaluate the mecha-nism and the origin of enantioselectivity in the C(sp2)‒H alkylative desymmetrization of cyclopentene-1,3-diones using nitroalkanes as the alkylatin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2225f4e3f7eee93de30dfc937771b142
https://doi.org/10.26434/chemrxiv-2021-x5mkp
https://doi.org/10.26434/chemrxiv-2021-x5mkp
Autor:
Nicole Poulides, Erdal Toprak, Madhu Sudan Manna, Uttam K. Tambar, Xiaoyu Wang, Da Nae R. Woodard, Ali Rana Atilgan, Yusuf Talha Tamer, John D. Hulleman, Noelle S. Williams, Andrew Y. Koh, Dominika Borek, Ayesha Ahmed, Canan Atilgan, Furkan C.R. Toprak, Ilona K. Gaszek
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
The antibiotic trimethoprim (TMP) is used to treat a variety of Escherichia coli infections, but its efficacy is limited by the rapid emergence of TMP-resistant bacteria. Previous laboratory evolution experiments have identified resistance-conferring
Publikováno v:
Chemical Science. 8:6686-6690
A formal umpolung strategy is presented for the enantioselective installation of an alkenyl group with a terminal double bond at a tertiary center. This one-pot two-step sequence relies on the unique features of the nitro group, which after inverting
Publikováno v:
Chemistry - A European Journal. 22:14912-14919
An enantioselective formal C(sp2)−H vinylation of prochiral 2,2-disubstituted cyclopentene-1,3-dione is presented. This vinylative desymmetrization is realized by using a two-step procedure that consists of a catalytic enantioselective vinylogous M
Autor:
Madhu Sudan Manna, Santanu Mukherjee
Publikováno v:
Chem. Sci.. 5:1627-1633
An efficient, robust and highly enantioselective catalytic desymmetrization of 2,2-disubstituted cyclopentene-1,3-diones is developed via direct vinylogous nucleophilic addition of deconjugated butenolides. A remarkable influence of the secondary cat
Autor:
Madhu Sudan Manna, Santanu Mukherjee
Publikováno v:
Chemistry - A European Journal. 18:15277-15282
Competition under control: A practical and efficient direct asymmetric vinylogous Michael reaction of deconjugated butenolides has been developed (see scheme). The products of this reaction, highly functionalized chiral succinimides, are obtained in
Publikováno v:
Chemistry (Weinheim an der Bergstrasse, Germany). 22(42)
An enantioselective formal C(sp
Autor:
Santanu Mukherjee, Madhu Sudan Manna
Publikováno v:
ChemInform. 46
The alkylative desymmetrization of prochiral 2,2-disubstituted cyclopentene-1,3-diones with nitroalkanes using a quinine-derived chiral catalyst is described.
Autor:
Madhu Sudan Manna, Santanu Mukherjee
Publikováno v:
ChemInform. 46
Catalytic asymmetric desymmetrization represents an excellent strategy for accessing highly functionalized chiral building blocks. However, the application of desymmetrization for the synthesis of enantioenriched cyclopentane derivatives remained lim