Zobrazeno 1 - 10 of 25 pro vyhledávání: '"Madhu P. Sirivelu"'
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Akademický článek
Circulating neurofilament light chain as a promising biomarker of AAV-induced dorsal root ganglia toxicity in nonclinical toxicology species
Autor: Kelly A. Fader, Ingrid D. Pardo, Ramesh C. Kovi, Christopher J. Somps, Helen Hong Wang, Vishal S. Vaidya, Shashi K. Ramaiah, Madhu P. Sirivelu
Publikováno v: Molecular Therapy: Methods & Clinical Development, Vol 25, Iss , Pp 264-277 (2022)
Adeno-associated virus (AAV)-induced dorsal root ganglia (DRG) toxicity has been observed in several nonclinical species, where lesions are characterized by neuronal degeneration/necrosis, nerve fiber degeneration, and mononuclear cell infiltration.
Externí odkaz: https://doaj.org/article/86125310200649c0a9c68fcd0e3733f4
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2
Methodologies and Emerging Technologies for the Evaluation of the Hematopoietic System
Autor: Florence Poitout-Belissent, Allison Vitsky, Mark A. Smith, Madhu P. Sirivelu
Publikováno v: Toxicologic Pathology. 50:867-870
Hematology and bone marrow analysis is central to our understanding of the hematopoietic system and how it responds to insults, and this session presented during the 2022 STP symposium provided a review of current and novel approaches for the evaluat
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b38a5c982a9c30ac7fd84045c6163af0
https://doi.org/10.1177/01926233221128755
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4
Circulating neurofilament light chain as a promising biomarker of AAV-induced dorsal root ganglia toxicity in nonclinical toxicology species
Autor: Kelly A. Fader, Ingrid D. Pardo, Ramesh C. Kovi, Christopher J. Somps, Helen Hong Wang, Vishal S. Vaidya, Shashi K. Ramaiah, Madhu P. Sirivelu
Adeno-associated virus (AAV)-induced dorsal root ganglia (DRG) toxicity has been observed in several nonclinical species, where lesions are characterized by neuronal degeneration/necrosis, nerve fiber degeneration, and mononuclear cell infiltration.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3887d189c54e6f093f86109ff2fb660f
https://doi.org/10.1101/2021.12.23.473896
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5
Biodistribution and Tolerability of AAV-PHP.B-CBh
Autor: Xavier, Palazzi, Ingrid D, Pardo, Madhu P, Sirivelu, Leah, Newman, Steven W, Kumpf, Jessie, Qian, Tania, Franks, Sarah, Lopes, June, Liu, Laura, Monarski, Sandra, Casinghino, Casey, Ritenour, Hayley, Ritenour, Christopher, Dubois, Jennifer, Olson, John, Graves, Kristin E, Alexander, Timothy, Coskran, Thomas A, Lanz, Joseph, Brady, Douglas, McCarty, Somanathan, Suryanarayan, Laurence O, Whiteley
Publikováno v: Human gene therapy. 33(3-4)
Recombinant adeno-associated viruses (AAVs) have emerged as promising vectors for human gene therapy, but some variants have induced severe toxicity in Rhesus monkeys and piglets following high-dose intravenous (IV) administration. To characterize bi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::794cfa4b206b8704a968304aa634a197
https://pubmed.ncbi.nlm.nih.gov/34931542
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6
Evaluation of the Central Effects of Systemic Lentiviral-Mediated Leptin Delivery in Streptozotocin-Induced Diabetic Rats
Autor: Kimberly A. Clark, Andrew C. Shin, Madhu P. Sirivelu, Ramya C. MohanKumar, Sreenivasa R. Maddineni, Ramesh Ramachandran, Puliyur S. MohanKumar, Sheba M. J. MohanKumar
Publikováno v: International Journal of Molecular Sciences, Vol 22, Iss 13197, p 13197 (2021)
International Journal of Molecular Sciences
International Journal of Molecular Sciences; Volume 22; Issue 24; Pages: 13197
Type 1 diabetes (T1D) is characterized by hyperphagia, hyperglycemia and activation of the hypothalamic–pituitary–adrenal (HPA) axis. We have reported previously that daily leptin injections help to alleviate these symptoms. Therefore, we hypothe
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b8ec12e3fa4cde56389208bb11c696c
https://doi.org/10.3390/ijms222413197
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8
Responsiveness of hypothalamo-pituitary-adrenal axis to leptin is impaired in diet-induced obese rats
Autor: Michelle James, Sheba M.J. MohanKumar, Puliyur S MohanKumar, Katrina D. Linning, Priya Balasubramanian, Madhu P. Sirivelu, Andrew Shin, Andrew Woolcock
Publikováno v: Nutrition & Diabetes
Nutrition & Diabetes, Vol 9, Iss 1, Pp 1-11 (2019)
Background/objectives Diet-induced obese (DIO) rats have altered stress (HPA) axis activity compared to diet-resistant (DR) rats when chronically exposed to a high-fat (HF) diet. Since stress axis is tightly regulated by leptin, an adipocyte-secreted
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::345653ec8e875a6c7632df251ed6aee9
https://doi.org/10.1038/s41387-019-0076-y
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9
Mitochondrial Translocator Protein (TSPO) Function Is Not Essential for Heme Biosynthesis
Autor: Roy Cohen, Amy H. Zhao, Kanako Morohaku, Lan N. Tu, Madhu P. Sirivelu, Viju V. Pillai, Chinatsu Mukai, Vimal Selvaraj
Publikováno v: Journal of Biological Chemistry. 291:1591-1603
Function of the mammalian translocator protein (TSPO; previously known as the peripheral benzodiazepine receptor) remains unclear because its presumed role in steroidogenesis and mitochondrial permeability transition established using pharmacological
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa87fcb8e1b41117f5f4fdc5725e3266
https://doi.org/10.1074/jbc.m115.686360
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