Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Madhu Gowravaram"'
Autor:
Madhu Gowravaram, Helena Käck, Ekundayo Osimoni, Charles J. Eyermann, Gregory S. Basarab, Pamela Hill
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:5600-5607
Structure-activity relationships are presented around a series of pyrazolopyrimidinediones that inhibit the growth of Helicobacter pylori by targeting glutamate racemase, an enzyme that provides d-glutamate for the construction of N-acetylglucosamine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba6af1a67e6ab049a153fe3d453efed3
https://doi.org/10.1016/j.bmcl.2012.07.004
https://doi.org/10.1016/j.bmcl.2012.07.004
Autor:
P. Ann Boriack-Sjodin, Lakshmaiah Gingipalli, Madhu Gowravaram, Amy Kutschke, Herbert Oguto, Kerry E. Murphy-Benenato, Sahil Patel, James T. Loch, Michele Johnstone, Dan Carcanague, Charles J. Eyermann, Matthew D. Miller, Harris Jahic, Gabriel Martínez-Botella, Georgine Ioannidis, Valerie A. Laganas, Jenna Harang, Michael R. Hale
Publikováno v:
Bioorganicmedicinal chemistry letters. 25(22)
Two novel compounds, pyridopyrimidines (1) and naphthyridines (2) were identified as potent inhibitors of bacterial NAD(+)-dependent DNA ligase (Lig) A in a fragment screening. SAR was guided by molecular modeling and X-ray crystallography. It was ob
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::596c0423dc15e4224bbd8ca0095c379d
https://pubmed.ncbi.nlm.nih.gov/26463129
https://pubmed.ncbi.nlm.nih.gov/26463129