Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Madhu Chari"'
Autor:
V. Madhu Chari, Robert Andrew McIvor
Publikováno v:
Canadian Respiratory Journal, Vol 2018 (2018)
Asthma is a chronic disease of airway inflammation with a large global burden. Despite established, guideline-based stepwise therapy, a significant proportion of patients remain symptomatic and poorly controlled. As such, there is a need for addition
Externí odkaz:
https://doaj.org/article/8054eced9f4647e28ab2a4c3b9344ae0
Autor:
Cecilia Pompili, Johnny Moons, Yaron Shargall, Alessandro Brunelli, Madhu Chari, Herbert Decaluwé
Publikováno v:
European Journal of Cardio-Thoracic Surgery. 54:122-126
OBJECTIVES The objective of this study was to evaluate the performance of 3 thoracic surgery centres using the Eurolung risk models for morbidity and mortality. METHODS This was a retrospective analysis performed on data collected from 3 academic cen
Autor:
Maureen J. Charron, Madhu Chari, Nikita R Christian, Jessica T.Y. Yue, Beatrice M. Filippi, Clair S. Yang, Carol K.L. Lam, Tony K.T. Lam, Patricia I. Mighiu, Mona A. Abraham
Publikováno v:
Nature Medicine. 19:766-772
Glucagon activates hepatic protein kinase A (PKA) to increase glucose production, but the gluco-stimulatory effect is transient even in the presence of continuous intravenous glucagon infusion. Continuous intravenous infusion of insulin, however, inh
Publikováno v:
Diabetes
OBJECTIVE Hypothalamic nutrient sensing regulates glucose production, but the neuronal circuits involved remain largely unknown. Recent studies underscore the importance of N-methyl-d-aspartate (NMDA) receptors in the dorsal vagal complex in glucose
Autor:
Tony K.T. Lam, Andrea Kokorovic, Grace W.C. Cheung, Madhu Chari, Carol K.L. Lam, Sun Gao, Isabelle Leclerc, Clair S. Yang, Guy A. Rutter
Publikováno v:
Diabetes
OBJECTIVE The fuel sensor AMP-activated protein kinase (AMPK) in the hypothalamus regulates energy homeostasis by sensing nutritional and hormonal signals. However, the role of hypothalamic AMPK in glucose production regulation remains to be elucidat
Publikováno v:
Cell Metabolism. 10(2):99-109
A recent study suggested that a rise of cholecystokinin (CCK8) in the duodenum may bring about an inhibition of hepatic glucose production. The authors made use of the pancreatic clamp technique to characterize a gut-brain-liver signal generated by C
Publikováno v:
Diabetes. 57:836-840
OBJECTIVE—Hypothalamic lactate metabolism lowers hepatic glucose production and plasma glucose levels in normal rodents. However, it remains unknown whether activation of hypothalamic lactate metabolism lowers glucose production and plasma glucose
Autor:
Tony K.T. Lam, Michelle Ang, Roger Gutierrez-Juarez, Xiaosong Li, Madhu Chari, Carol K.L. Lam, Liora Caspi, Peter E. Light, Penny Y.T. Wang, Gary J. Schwartz
Publikováno v:
Nature. 452:1012-1016
The mere presence of lipids in the intestine is known to reduce nutrient intake in both rodents and humans by activating the intestine–brain neural axis. More recently, studies have indicated that the brain senses blood lipids directly to inhibit g
Autor:
Tony K.T. Lam, Gary J. Schwartz, Luciano Rossetti, Carol K.L. Lam, Liora Caspi, Xiaosong Li, Madhu Chari, Evan D. Muse, Penny Y. T. Wang, Rachel A. Ross, Hiraku Ono, Roger Gutierrez-Juarez, Peter E. Light
Publikováno v:
Diabetes
OBJECTIVE—A selective rise in hypothalamic lipid metabolism and the subsequent activation of SUR1/Kir6.2 ATP-sensitive K+ (KATP) channels inhibit hepatic glucose production. The mechanisms that link the ability of hypothalamic lipid metabolism to t
Autor:
Katie Lee, Penny Y.T. Wang, Teresa Y.Y. Lai, Clair S. Yang, Madhu Chari, Tony K.T. Lam, Patricia I. Mighiu, Andrea Kokorovic, Carol K.L. Lam, Grace W.C. Cheung
Publikováno v:
Diabetes
OBJECTIVE Circulating glucose inhibits glucose production in normal rodents and humans, but this glucose effectiveness is disrupted in diabetes due partly to sustained hyperglycemia. We hypothesize that hyperglycemia in diabetes impairs hypothalamic