Single priming and a booster dose of 10-valent and 13-valent pneumococcal conjugate vaccine (PCV) maintains suppression of vaccine serotype colonization in South African children at 3, 4, and 5 years of age: a single-centre, open-labelled, randomized trial

Autor: Courtney P. Olwagen, Alane Izu, Lara Van der Merwe, Lisa Jose, Anthonet Koen, Shabir A. Madhi

Publikováno v: Expert Review of Vaccines, Vol 23, Iss 1, Pp 1011-1019 (2024)

Background Surveillance on nasopharyngeal Streptococcus pneumoniae carriage in older children would be informative in determining whether a single priming and booster dose of pneumococcal conjugate vaccine (PCV) provides durable protection against pn

Externí odkaz: https://doaj.org/article/1fe16186088c40d4ae74aecdf715b3b1

Risk factors for severe respiratory syncytial virus-associated respiratory tract infection in a high HIV prevalence setting, South Africa, 2012 – 2018

Autor: Jocelyn Moyes, Stefano Tempia, Sibongile Walaza, Adam L. Cohen, Florette Treurnicht, Orienka Hellferscee, Nicole Wolter, Anne von Gottberg, Halima Dawood, Ebrahim Variava, Kathleen Kahn, Shabir A. Madhi, Cheryl Cohen

Publikováno v: BMC Infectious Diseases, Vol 24, Iss 1, Pp 1-10 (2024)

Abstract Background Identifying risk factors for respiratory syncytial virus (RSV)–associated severe acute respiratory illness (SARI) will assist with targeting vaccine interventions. Methods Using surveillance data from South Africa (2012–2018),

Externí odkaz: https://doaj.org/article/f53b61d300d645698e38030a2748a7fe

Phylogenetic analysis of Klebsiella pneumoniae isolates of respiratory tract infections in humans and sheep

Autor: Khadeeja Sami Madhi, Alyaa Sabti Jasim, Hiba Ali Nasear, Hanaa Khaleel Ibraheim, Hasanain A.J. Gharban

Publikováno v: Open Veterinary Journal, Vol 14, Iss 9, Pp 2325-2333 (2024)

Background: Klebsiella pneumoniae is an important opportunistic pathogen, which is capable to colonizing the respiratory system in both human and animals causing mild to severe infections. Aim: This study aims to isolate K. pneumoniae from the nasal

Externí odkaz: https://doaj.org/article/b76b75ff4bde4cd1ae094baf467322a2

T-cell responses to ancestral SARS-CoV-2 and Omicron variant among unvaccinated pregnant and postpartum women living with and without HIV in South Africa

Autor: William C. McMahon, Gaurav Kwatra, Alane Izu, Stephanie A. Jones, Nkululeko J. Mbele, Nwabisa Jafta, Rushil Lala, Sharon Shalekoff, Caroline T. Tiemessen, Shabir A. Madhi, Marta C. Nunes

Publikováno v: Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)

Abstract SARS-CoV-2 cell-mediated immunity remains understudied during pregnancy in unvaccinated Black African women living with HIV (WLWH) from low- and middle-income countries. We investigated SARS-CoV-2-specific T-cell responses 1 month following

Externí odkaz: https://doaj.org/article/829efcf713b74a8283c2569667e633a0

Contribution of malnutrition to infant and child deaths in Sub-Saharan Africa and South Asia

Autor: Khatia Munguambe, Quique Bassat, Mahbubur Rahman, Sibone Mocumbi, Cynthia G Whitney, Amy Wise, Shams El Arifeen, Meerjady Sabrina Flora, Soter Ameh, Emily S Gurley, Mustafizur Rahman, Ariel Nhacolo, Cheick Bougadari Traore, Inacio Mandomando, Clara Menendez, Janet Agaya, Jane Juma, Shabir A Madhi, Tadesse Gure, George Aol, Hennie Lombaard, Ziyaad Dangor, James Bunn, Samba O Sow, Amara Jambai, Dickson Gethi, Sanwarul Bari, Natalia Rakislova, Tacilta Nhampossa, Maria Maixenchs, Mohammed Kamal, Joseph Oundo, Lola Madrid, Tahmina Shirin, Ikechukwu Udo Ogbuanu, Addisu Alemu, Hailemariam Legesse, Awa Traore, Portia C Mutevedzi, Helina Heluf, Victor Akelo, Dickens Onyango, Richard Omore, Yasmin Adam, Peter Otieno, Margaret Mannah, Karen L Kotloff, Milagritos D Tapia, Rima Koka, Mohammad Zahid Hossain, Dickens Kowuor, Tom Sesay, James Squire, Francis Moses, Kitiezo Aggrey Igunza, Andrew Moseray, Afruna Rahman, Nana Kourouma, Seydou Sissoko, Rosauro Varo, Sana Mahtab, Martin Hale, Jeanie du Toit, Zachary J Madewell, Dianna M Blau, Fatima Solomon, Gillian Sorour, Jeannette Wadula, Karen Petersen, Sanjay G Lala, Sithembiso Velaphi, Richard Chawana, Nellie Myburgh, Shahana Parveen, Mahbubul Hoque, Saria Tasnim, Ferdousi Islam, Farida Ariuman, Mohammad Mosiur Rahman, Dilruba Ahmed, Fikremelekot Temesgen, Melisachew Mulatu Yeshi, Mahlet Abayneh Gizaw, Stian MS Orlien, Solomon Ali, Peter Nyamthimba Onyango, Richard Oliech, Joyce Akinyi Were, Thomas Misore, Harun Owuor, Christopher Muga, Christine Ochola, Ashka Mehta, Brigitte Gaume, Adama Mamby Keita, Diakaridia Kone, Diakaridia Sidibe, Doh Sanogo, Kounandji Diarra, Tiéman Diarra, Kiranpreet Chawla, Zara Manhique, Fatmata Bintu Tarawally, Martin Seppeh, Ronald Mash, Julius Ojulong, Babatunde Duduyemi, Alim Swaray-Deen, Okokon Ita, Cornell Chukwuegbo, Sulaiman Sannoh, Princewill Nwajiobi, Erick Kaluma, Oluseyi Balogun, Carrie Jo Cain, Solomon Samura, Samuel Pratt, Joseph Kamanda Sesay, Osman Kaykay, Binyam Halu, Francis Smart, Sartie Kenneh, Ferdousi Begum, Priya Mehta-Gupta Das, Ogony Benard Oluoch, Caleb K Sagam, Ronita Luke, Milton Kincardett, Elisio G Xerinda, Markus Roos Breines, Ketema Degefa, J. Anthony G Scott, Kazi Munisul Islam, Parminder S Suchdev, Nelesh P. Govender, Peter J. Swart, Nawshad Uddin Ahmed, Alexander M. Ibrahim, Sharon M. Tennant, Carol L. Greene, J. Kristie Johnson, Karen D. Fairchild, Uma U. Onwuchekwa, Joseph Bangura

Publikováno v: BMJ Global Health, Vol 9, Iss 12 (2024)

Introduction Malnutrition contributes to 45% of all childhood deaths globally, but these modelled estimates lack direct measurements in countries with high malnutrition and under-5 mortality rates. We investigated malnutrition’s role in infant and

Externí odkaz: https://doaj.org/article/080ae47446d94bdfba6536fa9e658e9e