Overall survival with circulating tumor DNA-guided therapy in advanced non-small-cell lung cancer

Autor: Justin Jee, Emily S. Lebow, Randy Yeh, Jeeban P. Das, Azadeh Namakydoust, Paul K. Paik, Jamie E. Chaft, Gowtham Jayakumaran, A. Rose Brannon, Ryma Benayed, Ahmet Zehir, Mark Donoghue, Nikolaus Schultz, Debyani Chakravarty, Ritika Kundra, Ramyasree Madupuri, Yonina R. Murciano-Goroff, Hai-Yan Tu, Chong-Rui Xu, Andrés Martinez, Clare Wilhelm, Jesse Galle, Bobby Daly, Helena A. Yu, Michael Offin, Matthew D. Hellmann, Piro Lito, Kathryn C. Arbour, Marjorie G. Zauderer, Mark G. Kris, Kenneth K. Ng, Juliana Eng, Isabel Preeshagul, W. Victoria Lai, John J. Fiore, Afsheen Iqbal, Daniela Molena, Gaetano Rocco, Bernard J. Park, Lee P. Lim, Mark Li, Candace Tong-Li, Madhawa De Silva, David L. Chan, Connie I. Diakos, Malinda Itchins, Stephen Clarke, Nick Pavlakis, Adrian Lee, Natasha Rekhtman, Jason Chang, William D. Travis, Gregory J. Riely, David B. Solit, Mithat Gonen, Valerie W. Rusch, Andreas Rimner, Daniel Gomez, Alexander Drilon, Howard I. Scher, Sohrab P. Shah, Michael F. Berger, Maria E. Arcila, Marc Ladanyi, Ross L. Levine, Ronglai Shen, Pedram Razavi, Jorge S. Reis-Filho, David R. Jones, Charles M. Rudin, James M. Isbell, Bob T. Li

Publikováno v: Nature medicine. 28(11)

Circulating tumor DNA (ctDNA) sequencing guides therapy decisions but has been studied mostly in small cohorts without sufficient follow-up to determine its influence on overall survival. We prospectively followed an international cohort of 1,127 pat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d276500cbe7b30ce520bac26d2b720cf
https://pubmed.ncbi.nlm.nih.gov/36357679

Succinate dehydrogenase-deficient gastrointestinal stromal tumor: from diagnostic dilemma to novel personalised therapy in 2 case reports

Autor: Anthony J. Gill, Alexander Guminski, Sameer Rastogi, Christopher Angel, Owen W.J. Prall, Madhawa De Silva, David Chan

Publikováno v: Translational Cancer Research

Succinate dehydrogenase (SDH)-deficient gastrointestinal stromal tumor (GIST) is a unique and distinctive subtype of gastric GIST. The literature on this subtype from developing countries is exceedingly sparse. Patients with SDH-deficient GIST often

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cf69d2b1f32e49d6acead9ac938bf76
https://doi.org/10.21037/tcr-21-131

Relationship between PD-L1 expression and outcome in EGFR-mutant lung cancer patients treated with EGFR tyrosine kinase inhibitors

Autor: Vanathi Sivasubramaniam, Michael Boyer, Rina Hui, Jia Liu, Prunella Blinman, Jenny H. Lee, Nick Pavlakis, Stephen Clarke, Anthony J. Gill, Steven Kao, Winny Varikatt, Wendy A Cooper, Malinda Itchins, Megan B Barnet, Madhawa De Silva, Bo Gao, Alexander E. Davis, Adnan Nagrial, Kenneth Lee

Publikováno v: Lung cancer (Amsterdam, Netherlands). 155

Predictive biomarkers for poor response to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) is an area of ongoing research. This multicentre retrospective study sought to determine the impact of programmed death-ligand 1 (PD-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fff9c29ae2357a183bfd55710f7232a5
https://pubmed.ncbi.nlm.nih.gov/33721613

Abstract CT225: Phase 1 trial of SQ3370 in solid tumors

Autor: Vivek Bhadri, Jose M. Mejia Oneto, Vivek Subbiah, Nam Bui, Robert J. Steffner, Ding Wang, M. Wayne Saville, Madhawa De Silva, Sangeetha Srinivasan, Alexander Guminski, Nathan Yee

Publikováno v: Cancer Research. 81:CT225-CT225

Conventional chemotherapeutic agents are effective for a broad array of patients, but have limited dosing capabilities, lack specificity, and often result in systemic toxicity. Conversely, newer cancer immunotherapies have been successful but benefit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bcadcca0300f658c82244e168cbb556f
https://doi.org/10.1158/1538-7445.am2021-ct225

A Rapid Access Clinic to improve delivery of ambulatory care to cancer patients

Autor: James C, Kuo, Madhawa, De Silva, Chandra, Diwakarla, Desmond, Yip

Publikováno v: Asia-Pacific journal of clinical oncology. 13(3)

Cancer patients may find it challenging to access timely advice and care. We evaluated the improvement in delivering ambulatory care in establishing a Rapid Assessment Clinic (RAC) in a cancer center.Patients receiving chemotherapy who presented for

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::636b9213dc1c78ae6194fd98240e4fed
https://pubmed.ncbi.nlm.nih.gov/28004512