Výsledky vyhledávání - "Madhavi Sriram"

Synthesis of dihydronaphthalene analogues inspired by combretastatin A-4 and their biological evaluation as anticancer agents

Autor: Heling Zhou, Kevin G. Pinney, Yifan Wang, Tracy E. Strecker, Zhi Chen, Vani P. Mocharla, Casey J. Maguire, Ernest Hamel, David J. Chaplin, Madhavi Sriram, Ralph P. Mason, Mary Lynn Trawick, Ramona Lopez

Publikováno v: MedChemComm. 9:1649-1662

The natural products colchicine and combretastatin A-4 (CA4) have provided inspiration for the discovery and development of a wide array of derivatives and analogues that inhibit tubulin polymerization through a binding interaction at the colchicine

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e7384d367481400c25ac1c2bb02957c
https://doi.org/10.1039/c8md00322j

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Structure and Dynamic Behavior of Phosphine Gold(I)-Coordinated Enamines: Characterization of α-Metalated Iminium Ions

Autor: Yuyang Zhu, Amanda C. Jones, Madhavi Sriram, Andrew M. Camp, Cynthia S. Day

Publikováno v: Organometallics. 33:4157-4164

Cationic gold(I) enamine complexes with the (t-Bu)2(o-biphenyl)phosphine ligand were isolated and characterized by NMR spectroscopy and X-ray crystallography. The complexes display highly distorted coordination modes that are consistent with characte

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e64a6bd9e53b1ed3e7af74e54f9e7a50
https://doi.org/10.1021/om500670z

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Synthesis of structurally diverse benzosuberene analogues and their biological evaluation as anti-cancer agents

Autor: Kevin G. Pinney, Rajendra P. Tanpure, Christine A. Herdman, Chen-Ming Lin, David J. Chaplin, Matthew T. MacDonough, Laxman Devkota, Mary Lynn Trawick, Justin K. Tidmore, Tracy E. Strecker, Clinton S. George, Madhavi Sriram

Publikováno v: Bioorganic & Medicinal Chemistry. 21:8019-8032

Diversely functionalized, fused aryl-alkyl ring systems hold a prominent position as well-established molecular frameworks for a variety of anti-cancer agents. The benzosuberene (6,7 fused, also referred to as dihydro-5H-benzo[7]annulene and benzocyc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b2ffe22c532e72ae6d7ebeb9c2156ab
https://doi.org/10.1016/j.bmc.2013.08.035

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Design, synthesis, biochemical, and biological evaluation of nitrogen-containing trifluoro structural modifications of combretastatin A-4

Autor: Christopher J. Jelinek, George R. Pettit, Justin K. Tidmore, Tracy E. Strecker, Madhavi Sriram, G.D. Kishore Kumar, Mallinath B. Hadimani, Mary Lynn Trawick, John J. Hall, David J. Chaplin, Kevin G. Pinney

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 18:5146-5149

A new trifluorinated amino-combretastatin analogue, ( Z) -2-(4′-methoxy-3′-aminophenyl)-1-(3,4,5-trifluorophenyl)ethene, prepared by chemical synthesis, was found to be a potent inhibitor of tubulin assembly (IC 50 = 2.9 μM), and cytotoxic again

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5888082483e93431c2388d1229fecf9
https://doi.org/10.1016/j.bmcl.2008.07.070

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Carbon-14 radiosynthesis of combretastatin A-1 (CA1) and its corresponding phosphate prodrug (CA1P)

Autor: Kevin G. Pinney, Austin McMordie, Madhavi Sriram, David J. Chaplin, Victor L. Murrell, Suman Sharma, Rodney T. Brown

Publikováno v: Journal of Labelled Compounds and Radiopharmaceuticals.

The natural product combretastatin A-1 (CA1) is isolated from the African bush willow tree, a member of the Combretaceae family. CA1 has important medicinal value, due in part to its ability to inhibit tubulin assembly. The prodrug combretastatin A-1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f500651c44b5625f2180c8f065c085c3
https://doi.org/10.1002/jlcr.1676

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Design, synthesis and biological evaluation of dihydronaphthalene and benzosuberene analogs of the combretastatins as inhibitors of tubulin polymerization in cancer chemotherapy

Autor: Kevin G. Pinney, Mary Lynn Trawick, Madhavi Sriram, Taylor Wootton, John J. Hall, Tracy E. Strecker, Andreas Franken, Nathan C. Grohmann

Publikováno v: Bioorganicmedicinal chemistry. 16(17)

A novel series of dihydronaphthalene and benzosuberene analogs bearing structural similarity to the combretastatins in terms of 1,2-diarylethene, trimethoxyphenyl, and biaryl functionality has been synthesized. The compounds have been evaluated in re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2a019596fcc9feff9cb8bc8260b258e
https://pubmed.ncbi.nlm.nih.gov/18722127

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An amino-benzosuberene analogue that inhibits tubulin assembly and demonstrates remarkable cytotoxicity

Autor: Kevin G. Pinney, Mary Lynn Trawick, David J. Chaplin, Tracy E. Strecker, Rajendra P. Tanpure, Amanda K. Charlton-Sevcik, Justin K. Tidmore, Ernest Hamel, Clinton S. George, Madhavi Sriram

Publikováno v: MedChemComm. 3:720

The recent discovery of a small-molecule benzosuberene-based phenol that demonstrates remarkable picomolar cytotoxicity against selected human cancer cell lines and strongly inhibits tubulin polymerization (1–2 µM) inspired the design and synthesi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db641b90b7e84d4f63ba2370ec18c815
https://doi.org/10.1039/c2md00318j

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