Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Madhavi Pannala"'
Autor:
Madhavi Pannala, Sunil Kher, Ila Sircar, Rick Jack, Kirk Lake, Shao-Hui Zhang, James Zapf, Lisa Morera, Juping Liu, Kui Xu, Farid Bakir, Jie-Fei Cheng, Naoki Sakurai
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:4442-4446
Structure-activity relationship studies on a series of Boc-indole derivatives as LXR agonists are described. Compound 1 was identified as an LXR agonist through structure-based virtual screening followed by high-throughput gene profiling. Replacement
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b33d8f8884334c3855313d44722c5fe
https://doi.org/10.1016/j.bmcl.2007.06.017
https://doi.org/10.1016/j.bmcl.2007.06.017
Autor:
Ila Sircar, Chiaki Fukushima, Lisa Schneider, James Zapf, Madhavi Pannala, Lisa Morera, Trang Nguyen, Jie-Fei Cheng, Rick Jack, Norma Wilson, Shao-Hui Zhang, Kui Xu, Farid Bakir, Juping Liu, Kei Takedomi, Naoki Sakurai, Sunil Kher
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:3473-3479
A structurally novel liver X receptor (LXR) agonist (1) was identified from internal compound collection utilizing the combination of structure-based virtual screening and high-throughput gene profiling. Compound 1 increased ABCA1 gene expression by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7eb508e31f7c0f8a1fb69a6abab291c
https://doi.org/10.1016/j.bmcl.2007.03.076
https://doi.org/10.1016/j.bmcl.2007.03.076
Autor:
Hari Babu Mereyala, Madhavi Pannala
Publikováno v:
Journal of the Chemical Society, Perkin Transactions 1. :1755-1758
myo-Inositol 8 has been converted to biscyclohexylidene ketals 9–11. The inseparable mixture of isomers 9 and 11 has been utilised as such to obtain the synthetically useful (±)-trans-cyclohexa-3,5-diene-1,2-diol derivative 24 via the intermediate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1e3f85d50cf41b68efa4716a8d976733
https://doi.org/10.1039/a605576a
https://doi.org/10.1039/a605576a
Autor:
Madhavi Pannala, Hari Babu Mereyala
Publikováno v:
Tetrahedron Letters. 36:2121-2124
Synthesis of (meso)1,2-O-cyclohexylidene-cyclohexa-3,4-diene (4) in four steps from myo-inositol and its exclusive conversion to the vinylic epoxide 13 is described.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b8d1869c75d3fd473dd690a965786877
https://doi.org/10.1016/0040-4039(95)00188-i
https://doi.org/10.1016/0040-4039(95)00188-i
Publikováno v:
Tetrahedron Letters. 42:1475-1477
Heterocyclic 5-amino uracil derivatives were prepared by catalytic amination of 1,3-dibenzyl-5-iodouracil using (CuOTf)2·PhH, 1,10-phenanthroline, dibenzylidene acetone, and Cs2CO3 as base in xylenes at 95°C. Imidazole and 2-amino thiazoline were p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::909839dfbfac3067ab422e3eaacde2ba
https://doi.org/10.1016/s0040-4039(00)02315-7
https://doi.org/10.1016/s0040-4039(00)02315-7
Autor:
Hari Babu Mereyala, Madhavi Pannala
Publikováno v:
ChemInform. 26
Synthesis of (meso)1,2-O-cyclohexylidene-cyclohexa-3,4-diene (4) in four steps from myo-inositol and its exclusive conversion to the vinylic epoxide 13 is described.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ad39cf8ab810386c48d91d1fe4409248
https://doi.org/10.1002/chin.199530137
https://doi.org/10.1002/chin.199530137
Autor:
Madhavi Pannala, Hari Babu Mereyala
Publikováno v:
ChemInform. 28
myo-Inositol 8 has been converted to biscyclohexylidene ketals 9–11. The inseparable mixture of isomers 9 and 11 has been utilised as such to obtain the synthetically useful (±)-trans-cyclohexa-3,5-diene-1,2-diol derivative 24 via the intermediate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0b8429b456644a50e79e5c074c845e71
https://doi.org/10.1002/chin.199743220
https://doi.org/10.1002/chin.199743220
Publikováno v:
Tetrahedron Letters. 41:7847-7849
Catalytic transfer hydrogenation using palladium(II) chloride, formate and aqueous sodium hydroxide is effective for the reduction of unsaturated carboxylic acids, azalactones, and α-ketocarboxylic acids. This method is convenient, economical, avoid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3c652cbe34d4c58f11ec2ccb94396179
https://doi.org/10.1016/s0040-4039(00)01365-4
https://doi.org/10.1016/s0040-4039(00)01365-4
Autor:
Sunil Kher, Alexei Bakhirev, Madhavi Pannala, Naoki Sakurai, Norma Wilson, Frank Gorcsan, Ila Sircar, Guang Yang, Shao-Hui Zhang, Jie-Fei Cheng, John A. Gaudette, Miguel Barbosa, Phoebe Yuen
Publikováno v:
Bioorganicmedicinal chemistry letters. 17(21)
Synthesis and structure–activity relationship of a series of 4-(2-aryl-cyclopropylamino)-quinoline-3-carbonitrile derivatives as EGFR inhibitors is described. Compounds 29 and 30 showed potent in vitro inhibitory activity in the enzymatic assay as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18bfca4f8571d6fa7497bc1c707df1aa
https://pubmed.ncbi.nlm.nih.gov/17827009
https://pubmed.ncbi.nlm.nih.gov/17827009
Publikováno v:
ChemInform. 31
Catalytic transfer hydrogenation using palladium(II) chloride, formate and aqueous sodium hydroxide is effective for the reduction of unsaturated carboxylic acids, azalactones, and α-ketocarboxylic acids. This method is convenient, economical, avoid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f1d05a588350b55e2556f360321d9181
https://doi.org/10.1002/chin.200052078
https://doi.org/10.1002/chin.200052078