Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Madhavi P. Kadakia"'
Autor:
Amjad A. Aljagthmi, Akshay Hira, Jin Zhang, Mariana Cooke, Marcelo G. Kazanietz, Madhavi P. Kadakia
Publikováno v:
Cell Death Discovery, Vol 10, Iss 1, Pp 1-8 (2024)
Abstract ΔNp63α, a member of the p53 family of transcription factors, plays a critical role in maintaining the proliferative potential of stem cells in the stratified epithelium. Although ΔNp63α is considered an oncogene and is frequently overexp
Externí odkaz:
https://doaj.org/article/055e3aa304f34c3ab1657697ec0e9d62
Autor:
Eid S. Alshammari, Amjad A. Aljagthmi, Andrew J. Stacy, Mike Bottomley, H. Nicholas Shamma, Madhavi P. Kadakia, Weiwen Long
Publikováno v:
BMC Cancer, Vol 21, Iss 1, Pp 1-12 (2021)
Abstract Background p63, a member of the p53 gene family, is an important regulator for epithelial tissue growth and development. ∆Np63α is the main isoform of p63 and highly expressed in Non-melanoma skin cancer (NMSC). Extracellular signal-regul
Externí odkaz:
https://doaj.org/article/b91dda3109c34727af0adb4d89f0e177
Autor:
Kristina Hertzler-Schaefer, Grinu Mathew, Ally-Khan Somani, Sunil Tholpady, Madhavi P. Kadakia, Yiping Chen, Dan F. Spandau, Xin Zhang
Publikováno v:
Cell Reports, Vol 6, Iss 5, Pp 818-826 (2014)
Inactivation of the Pten tumor suppressor negatively regulates the PI3K-mTOR pathway. In a model of cutaneous squamous cell carcinoma (SCC), we demonstrate that deletion of Pten strongly elevates Fgf10 protein levels without increasing Fgf10 transcri
Externí odkaz:
https://doaj.org/article/ba469c189cb9470e81ae9d4479c0b9d7
Publikováno v:
Cancer Research. 83:400-400
About 5.4 million basal and squamous cell skin cancers are diagnosed each year in the US. The chemotherapeutic drug, Cisplatin is often used to treat squamous cell carcinoma (SCC) patients, but low response rates and disease recurrence is common. ΔN
Publikováno v:
J Biol Chem
An estimated 5.4 million cases of nonmelanoma skin cancer are reported in the United States at an associated cost of $4.8 billion. ΔNp63α, a proto-oncogene in the p53 family of transcription factors, is overexpressed in squamous cell carcinoma (SCC
Autor:
Cameron M. Crasto, Joshua A. Hagen, Rajesh R. Naik, Oksana M. Pavlyuk, Joseph M. Slocik, Nancy Kelley-Loughnane, Ming-Siao Hsiao, Lawrence F. Drummy, Yen Ngo, Steve S. Kim, Li Xing, Rhett L. Martineau, Ahmad E. Islam, Cheri M. Hampton, Madhavi P. Kadakia
Publikováno v:
ACS Applied Materials & Interfaces. 11:13927-13934
Transmission electron microscopy (TEM) is being pushed to new capabilities which enable studies on systems that were previously out of reach. Among recent innovations, TEM through liquid cells (LC-TEM) enables in operando observation of biological ph
Autor:
Elie Ghanem, S. Louis Bridges, Christian Kelly, Gabriel Touliatos, Jasvinder A. Singh, Jeremy McAdam, Jin Zhang, Scott E. Schutzler, Derek Wiggins, Michael P. Craig, Sufen Yang, Marcas M. Bamman, Madhavi P. Kadakia, Inmaculada Aban, Herrick Siegel, Lowry Barnes, Arny A. Ferrando, Regina Seay, Kaleen M. Lavin, Devin Drummer
Publikováno v:
Medicine & Science in Sports & Exercise. 53:465-466
Autor:
Jason A Lehman, Paula M Hauck, Jaimie M Gendron, Christopher N Batuello, Jacob A Eitel, Allan Albig, Madhavi P Kadakia, Lindsey D Mayo
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e74741 (2013)
Serdemetan (JNJ-26854165), an antagonist to Mdm2, was anticipated to promote the activation of p53. While regulation of p53 by Mdm2 is important, Mdm2 also regulates numerous proteins involved in diverse cellular functions. We investigated if Serdeme
Externí odkaz:
https://doaj.org/article/7275d8cc4eaa42faa9106b18ff10b8e3
Autor:
Andrew J. Stacy, Mike Bottomley, H. Nicholas Shamma, Madhavi P. Kadakia, Eid S. Alshammari, Amjad Ahmed Aljagthmi, Weiwen Long
Publikováno v:
BMC Cancer
BMC Cancer, Vol 21, Iss 1, Pp 1-12 (2021)
BMC Cancer, Vol 21, Iss 1, Pp 1-12 (2021)
Background p63, a member of the p53 gene family, is an important regulator for epithelial tissue growth and development. ∆Np63α is the main isoform of p63 and highly expressed in Non-melanoma skin cancer (NMSC). Extracellular signal-regulated kina
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bffba543eb26dab8f7c843d85c70064
https://doi.org/10.21203/rs.2.23512/v1
https://doi.org/10.21203/rs.2.23512/v1
Autor:
Nikhil Reddy, Sangeeta Agrawal, Jin Zhang, Madhavi P. Kadakia, Sumudu Rajakaruna, Srivats Madhavan, Michael P. Craig, Oleg Paliy, Michael Bottomley, Mumtaz Sajjad
Publikováno v:
Clinical and Translational Gastroenterology
Objectives Barrett's esophagus (BE) is the precursor lesion and a major risk factor for esophageal adenocarcinoma (EAC). Although patients with BE undergo routine endoscopic surveillance, current screening methodologies have proven ineffective at ide