Zobrazeno 1 - 10
of 88
pro vyhledávání: '"Madhavi J Rane"'
Publikováno v:
Innate Immunity, Vol 25 (2019)
LPS delays neutrophil apoptosis by a process generally assumed to involve cell-intrinsic TLR4 signaling. However, neutrophil survival responses to LPS have been reported to be monocyte-dependent, which would indicate more complexity than is currently
Externí odkaz:
https://doaj.org/article/37ab62359240437aaeedac625e827880
Autor:
Shunying Jin, Michael L Merchant, Jeffrey D Ritzenthaler, Kenneth R McLeish, Eleanor D Lederer, Edilson Torres-Gonzalez, Mostafa Fraig, Michelle T Barati, Alex B Lentsch, Jesse Roman, Jon B Klein, Madhavi J Rane
Publikováno v:
PLoS ONE, Vol 10, Iss 4, p e0121637 (2015)
Immune-complexes play an important role in the inflammatory diseases of the lung. Neutrophil activation mediates immune-complex (IC) deposition-induced acute lung injury (ALI). Components of gamma amino butyric acid (GABA) signaling, including GABA B
Externí odkaz:
https://doaj.org/article/241d62c110c54c75a52fcfa8b728e13c
Autor:
Othello Del Rosario, Karthik Suresh, Medha Kallem, Gayatri Singh, Anika Shah, Linda Zheng, Xin Yun, Nicolas M. Philip, Nirupama Putcha, Marni B. McClure, Haiyang Jiang, Franco D’Alessio, Meera Srivastava, Alakesh Bera, Larissa A. Shimoda, Michael Merchant, Madhavi J. Rane, Carolyn E. Machamer, Jason Mock, Robert Hagan, Abigail L. Koch, Naresh M. Punjabi, Todd M. Kolb, Mahendra Damarla
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 324:L700-L711
We have previously identified mitogen-activated protein kinase-activated protein kinase 2 (MK2) is required for caspase-3 nuclear translocation in the execution of apoptosis; however, little is known of the underlying mechanisms. Therefore, we sought
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::48de92817e39ab7746442bb9e635edfa
https://doi.org/10.1152/ajplung.00340.2022
https://doi.org/10.1152/ajplung.00340.2022
Autor:
Karthik Suresh, Othello Del Rosario, Medha Kallem, Gayatri Singh, Anika Shah, Linda Zheng, Xin Yun, Nicolas M. Philip, Nirupama Putcha, Marni B. McClure, Haiyang Jiang, Franco D’Alessio, Meera Srivastava, Alakesh Bera, Larissa A. Shimoda, Michael Merchant, Madhavi J. Rane, Carolyn E. Machamer, Jason Mock, Robert Hagan, Abigail L. Koch, Naresh M. Punjabi, Todd M. Kolb, Mahendra Damarla
Publikováno v:
Physiological Genomics. 55:168-178
MK2, known to promote caspase-3 nuclear translocation in the execution of apoptosis, is reduced in non-small cell lung cancer cells. In adenocarcinomas of patients, higher MK2 expression is associated with early-stage disease, better clinical respons
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4858e57e9d5950f2a285f4ab23fa97ee
https://doi.org/10.1152/physiolgenomics.00155.2022
https://doi.org/10.1152/physiolgenomics.00155.2022
Publikováno v:
Journal of Cellular and Molecular Medicine
Transcription factor Krüppel‐like factor 5 (KLF5) is a member of the Krüppel‐like factors’ (KLFs) family. KLF5 regulates a number of cellular functions, such as apoptosis, proliferation and differentiation. Therefore, KLF5 can play a role in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ea6a19d36470c0fb68c2a44a6a040f2
https://doi.org/10.1111/jcmm.16332
https://doi.org/10.1111/jcmm.16332
Autor:
Kenneth R. McLeish, Rejeena Shrestha, Aruna Vashishta, Madhavi J. Rane, Michelle T. Barati, Michael E. Brier, Mario Gutierrez Lau, Xiaoling Hu, Oscar Chen, Caitlin R. Wessel, Travis Spalding, Sarah E. Bush, Kenechi Ijemere, C. Danielle Hopkins, Elizabeth A. Cooke, Shweta Tandon, Terri Manning, Silvia M. Uriarte, Jiapeng Huang, Jun Yan
Publikováno v:
Frontiers in Immunology. 13
Neutrophils play a significant role in determining disease severity following SARS-CoV-2 infection. Gene and protein expression defines several neutrophil clusters in COVID-19, including the emergence of low density neutrophils (LDN) that are associa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1186f512ea9ffac2cd7697b11da6862a
Autor:
Othello Del Rosario, Karthik Suresh, Medha Kallem, Gayatri Singh, Anika Shah, Yun Xin, Nicolas M. Philip, Haiyang Jiang, Franco D’Alessio, Meera Srivastava, Alakesh Bera, Larissa A. Shimoda, Michael Merchant, Madhavi J. Rane, Carolyn E. Machamer, Jason Mock, Robert Hagan, Todd M. Kolb, Mahendra Damarla
Non-small cell lung cancers demonstrate intrinsic resistance to cell death even in response to chemotherapy. Previous work suggested that defective nuclear translocation of active caspase 3 may play a role in resistance to cell death. Separately, our
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c5f3aa606f557d4748e0f31076bd9cd5
https://doi.org/10.1101/2021.11.30.470656
https://doi.org/10.1101/2021.11.30.470656
Autor:
Susan Coventry, Michelle T. Barati, Eleanor D. Lederer, Leah J. Siskind, Tess V. Dupre, Adrienne M. Bushau-Sprinkle, Caryl Conklin, Syed J. Khundmiri, Barbara J. Clark, Madhavi J. Rane, Kenneth B. Gagnon, Michael E. Brier, Mark A. Doll
Publikováno v:
The American Journal of Pathology. 189:1190-1200
Na+/H+ exchange regulatory cofactor (NHERF)-1, a scaffolding protein, anchors multiple membrane proteins in renal proximal tubules. Cultured proximal tubule cells deficient in Nherf1 and proximal tubules from Nherf1-deficient mice exhibit aberrant tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f26882d04950d1ec8a90b9fd883b8d1e
https://doi.org/10.1016/j.ajpath.2019.02.010
https://doi.org/10.1016/j.ajpath.2019.02.010
Autor:
Steven S. An, Madhavi J. Rane, Laura Johnston, Steven M. Dudek, Laura Servinsky, Kathleen Carino, Hong Lam, Mahendra Damarla, Karthik Suresh, Carolyn E. Machamer, Larissa A. Shimoda, Todd M. Kolb
Publikováno v:
Am J Physiol Lung Cell Mol Physiol
Noncanonical roles for caspase-3 are emerging in the fields of cancer and developmental biology. However, little is known of nonapoptotic functions of caspase-3 in most cell types. We have recently demonstrated a disassociation between caspase-3 acti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edc17cafe9c1f81b2e5de7cec3de309b
https://doi.org/10.1152/ajplung.00487.2018
https://doi.org/10.1152/ajplung.00487.2018
Publikováno v:
EBioMedicine, Vol 40, Iss, Pp 743-750 (2019)
EBioMedicine
EBioMedicine
Dysregulated Krϋppel-like factor (KLF) gene expression appears in many disease-associated pathologies. In this review, we discuss physiological functions of KLFs in the kidney with a focus on potential pharmacological modulation/therapeutic applicat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd285da21981527b66a0c90f7c96a0b6
http://www.sciencedirect.com/science/article/pii/S235239641930026X
http://www.sciencedirect.com/science/article/pii/S235239641930026X