Výsledky vyhledávání - "Madhavi Challa-Malladi"

zRICH, a protein induced during optic nerve regeneration in zebrafish, promotes neuritogenesis and interacts with tubulin

Autor: Madhavi Challa-Malladi, Rafael P. Ballestero, Karthik R. Chamakura, Cheryl J. Claunch, Satya Pathi, Suman Govindaraju, Soumia Jose, Maribel González-García, Hannah E. Romo, Juan A. Conde, Ana Benito-Martín

Publikováno v: Brain Research. 1474:29-39

Mammals do not regenerate axons in their central nervous system (CNS) spontaneously. This phenomenon is the cause of numerous medical conditions after damage to nerve fibers in the CNS of humans. The study of the mechanisms of nerve regeneration in o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5c4f2b40f4b02d125a4ae0123412a80
https://doi.org/10.1016/j.brainres.2012.07.057

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Nuclear factor-κB-inducing kinase (NIK) contains an amino-terminal inhibitor of apoptosis (IAP)-binding motif (IBM) that potentiates NIK degradation by cellular IAP1 (c-IAP1)

Autor: Sunhee Lee, Madhavi Challa-Malladi, Shawn B. Bratton, Casey W. Wright

Publikováno v: The Journal of biological chemistry. 289(44)

Activation of the noncanonical NF-κB pathway hinges on the stability of the NF-κB-inducing kinase (NIK), which is kept at low levels basally by a protein complex consisting of the E3 ubiquitin ligases cellular inhibitor of apoptosis 1 and 2 (c-IAP1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::489ba81ca57c6f298d65bffc757c15d9
https://pubmed.ncbi.nlm.nih.gov/25246529

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Apoptosis

Autor: Madhavi Challa-Malladi, Shawn B. Bratton, Srinivas Malladi

Apoptosis plays a critical role during normal development and homeostasis of adult tissues. Consequently, deregulation of apoptosis is commonly associated with diseases ranging from cancer to neurodegeneration. Toxicants also induce cell death via ap

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d8c314d91e91b0867ce8d142ee714a2a
https://doi.org/10.1016/b978-0-08-046884-6.00231-1

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The apaf-1•procaspase-9 apoptosome complex functions as a proteolytic-based molecular timer

Autor: Srinivas Malladi, Howard O. Fearnhead, Madhavi Challa-Malladi, Shawn B. Bratton

During stress-induced apoptosis, the initiator caspase-9 is activated by the Apaf-1 apoptosome and must remain bound to retain significant catalytic activity. Nevertheless, in apoptotic cells the vast majority of processed caspase-9 is paradoxically

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9475520a5a6d93e6fd390b454444369b
http://hdl.handle.net/10379/12614

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