Evaluation of mRNA-1273 Vaccine in Children 6 Months to 5 Years of Age

Autor: Evan J, Anderson, C Buddy, Creech, Vladimir, Berthaud, Arin, Piramzadian, Kimball A, Johnson, Marcus, Zervos, Fredric, Garner, Carl, Griffin, Khozema, Palanpurwala, Mark, Turner, Jeffrey, Gerber, Richard L, Bennett, Kashif, Ali, Madhavi, Ampajwala, Gary, Berman, Jennifer, Nayak, Carey, Chronis, Barbara, Rizzardi, William J, Muller, Christopher A, Smith, George, Fuchs, Daniel, Hsia, Joanne E, Tomassini, Dianne, DeLucia, Caroline, Reuter, Barbara, Kuter, Xiaoping, Zhao, Weiping, Deng, Honghong, Zhou, Daniela, Ramirez Schrempp, Kelly, Hautzinger, Bethany, Girard, Karen, Slobod, Roderick, McPhee, Rolando, Pajon, Anne, Aunins, Rituparna, Das, Jacqueline M, Miller, Sabine, Schnyder Ghamloush, Yamna, Ali

Publikováno v: The New England journal of medicine. 387(18)

The safety, reactogenicity, immunogenicity, and efficacy of the mRNA-1273 coronavirus disease 2019 (Covid-19) vaccine in young children are unknown.Part 1 of this ongoing phase 2-3 trial was open label for dose selection; part 2 was an observer-blind

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87d962af5aa5330e6d7710b72ead9c40
https://pubmed.ncbi.nlm.nih.gov/36260859

Oseltamivir, amantadine, and ribavirin combination antiviral therapy versus oseltamivir monotherapy for the treatment of influenza: a multicentre, double-blind, randomised phase 2 trial

Autor: John H Beigel, Yajing Bao, Joy Beeler, Weerawat Manosuthi, Alex Slandzicki, Sadia M Dar, John Panuto, Richard L Beasley, Santiago Perez-Patrigeon, Gompol Suwanpimolkul, Marcelo H Losso, Natalie McClure, Dawn R Bozzolo, Christopher Myers, H Preston Holley, Justin Hoopes, H Clifford Lane, Michael D Hughes, Richard T Davey, Michael Winnie, Dinh V Dinh, Raghu Seethala, Hiram Garcia, Joe Pouzar, Michael Seep, Ernie Riffer, Belinda Bart, Sadia Dar, Melanie Hoppers, Heather Rowe, Cameron Wolfe, Donna Desantis, Barr Baynton, Norman Markowitz, Zebediah A Stearns, Josalyn Cho, Marcy Goisse, Thomas A Wolf, Jennifer Kay, Nila Dharan, William Fitzgibbons, Mark Woodruff, Todd Bell, Thomas Lenzmeier, Robert Schooley, Marie-Carmelle Elie, Patricia Winokur, Robert Finberg, Christopher Hurt, Pablo Tebas, Fred R Sattler, Madhavi Ampajwala, Donald Batts, Mark Bloch, Richard Moore, Dominic Dwyer, Javier Romo-Garcia, Santiago Perez Patrigeon, Ana Patricia Rodríguez Zulueta, Ploenchan Chetchotisakd, Kiat Ruxrungtham, Anchalee Avihingsanon, Winai Ratanasuwan, Sergio Lupo, Liliana Trape, Laura M Macias, Gustavo Lopardo, Laura Barcelona, Analia Mykietuk, Maria F Alzogaray

Publikováno v: The Lancet. Infectious diseases

Summary Background Influenza continues to have a substantial socioeconomic and health impact despite a long established vaccination programme and approved antivirals. Preclinical data suggest that combining antivirals might be more effective than adm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::862b46a545f37ada255312740288945c
https://pubmed.ncbi.nlm.nih.gov/28958679