Výsledky vyhledávání - "Madhavi, Cheruvu"

Concomitant angiotensin AT1 receptor antagonism and neprilysin inhibition produces omapatrilat-like antihypertensive effects without promoting tracheal plasma extravasation in the rat

Autor: Rachael Olsufka, Craig M. Hill, Travis Renner, Uwe Klein, Scott Armstrong, Harold Thibodeaux, Sharath S. Hegde, Timothy Park, Joe Budman, Cecile Yu, Madhavi Cheruvu, Laxminarayan G Hegde, Erik R Sandvik, Cassie E Lane

Publikováno v: Journal of cardiovascular pharmacology. 57(4)

Dual inhibition of angiotensin-converting enzyme (ACE) and neprilysin (NEP) by drugs such as omapatrilat produces superior antihypertensive efficacy but cause high incidence of angioedema. We examined whether dual inhibition of angiotensin AT1 recept

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::903e94b8f8056c648408192979b7339b
https://pubmed.ncbi.nlm.nih.gov/21297495

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Comparative preclinical assessment of angioedema risk of inhibitors of renin‐angiotensin system and neprilysin in the anesthetized rat tracheal plasma extravasation assay

Autor: Jennifer Villarreal, Sharathchandra S Hegde, Laxminarayan G Hegde, Rachael Olsufka, Scott Armstrong, Cecile Yu, Madhavi Cheruvu, Harold Thibodeaux, Carrie Richardson

Publikováno v: The FASEB Journal. 23

Angiotensin converting enzyme inhibitors (ACEi) and dual acting ACEi-neprilysin (NEP) inhibitors are associated with risk of angioedema in the clinic. In the present study, we used a rodent model t...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e1462fd21136004792b95f0222b8ac7d
https://doi.org/10.1096/fasebj.23.1_supplement.lb379

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