Zobrazeno 1 - 10
of 406
pro vyhledávání: '"Madhav Thambisetty"'
Autor:
Keenan A. Walker, Yang An, Abhay Moghekar, Ruin Moaddel, Michael R. Duggan, Zhongsheng Peng, Qu Tian, Luke C. Pilling, Shannon M. Drouin, Mark A. Espeland, Stephen R Rapp, Kathleen M Hayden, Aladdin H. Shadyab, Ramon Casanova, Madhav Thambisetty, Peter R. Rapp, Dimitrios Kapogiannis, Luigi Ferrucci, Susan M. Resnick
Publikováno v:
Molecular Neurodegeneration, Vol 19, Iss 1, Pp 1-18 (2024)
Abstract Background Apolipoprotein E (APOE) ε4 allele is the strongest genetic risk factor for late onset Alzheimer’s disease (AD). This case-cohort study used targeted plasma biomarkers and large-scale proteomics to examine the biological mechani
Externí odkaz:
https://doaj.org/article/ee7fd18cf0994326a5954b2b904a2e34
Autor:
Przemysław R. Kac, Fernando González-Ortiz, Andreja Emeršič, Maciej Dulewicz, Srinivas Koutarapu, Michael Turton, Yang An, Denis Smirnov, Agnieszka Kulczyńska-Przybik, Vijay R. Varma, Nicholas J. Ashton, Laia Montoliu-Gaya, Elena Camporesi, Izabela Winkel, Bogusław Paradowski, Abhay Moghekar, Juan C. Troncoso, Tammaryn Lashley, Gunnar Brinkmalm, Susan M. Resnick, Barbara Mroczko, Hlin Kvartsberg, Milica Gregorič Kramberger, Jörg Hanrieder, Saša Čučnik, Peter Harrison, Henrik Zetterberg, Piotr Lewczuk, Madhav Thambisetty, Uroš Rot, Douglas Galasko, Kaj Blennow, Thomas K. Karikari
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Blood phosphorylated tau (p-tau) biomarkers, including p-tau217, show high associations with Alzheimer’s disease (AD) neuropathologic change and clinical stage. Certain plasma p-tau217 assays recognize tau forms phosphorylated additionally
Externí odkaz:
https://doaj.org/article/cd9a96562fae4bf787bc8b6e650f5603
Autor:
Nicholas J. Ashton, Shorena Janelidze, Ahmad Al Khleifat, Antoine Leuzy, Emma L. van der Ende, Thomas K. Karikari, Andrea L. Benedet, Tharick A. Pascoal, Alberto Lleó, Lucilla Parnetti, Daniela Galimberti, Laura Bonanni, Andrea Pilotto, Alessandro Padovani, Jan Lycke, Lenka Novakova, Markus Axelsson, Latha Velayudhan, Gil D. Rabinovici, Bruce Miller, Carmine Pariante, Naghmeh Nikkheslat, Susan M. Resnick, Madhav Thambisetty, Michael Schöll, Gorka Fernández-Eulate, Francisco J. Gil-Bea, Adolfo López de Munain, Ammar Al-Chalabi, Pedro Rosa-Neto, Andre Strydom, Per Svenningsson, Erik Stomrud, Alexander Santillo, Dag Aarsland, John C. van Swieten, Sebastian Palmqvist, Henrik Zetterberg, Kaj Blennow, Abdul Hye, Oskar Hansson
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Cerebrospinal fluid neurofilament light (NfL) is a biomarker for neurodegeneration that can also be assessed in blood. Here the authors show in a validation study the potential for plasma NfL as a biomarker for several neurodegenerative diseases.
Externí odkaz:
https://doaj.org/article/5a53b0a732414b4ca05246e46c25baa3
Autor:
Vijay R. Varma, H. Büşra Lüleci, Anup M. Oommen, Sudhir Varma, Chad T. Blackshear, Michael E. Griswold, Yang An, Jackson A. Roberts, Richard O’Brien, Olga Pletnikova, Juan C. Troncoso, David A. Bennett, Tunahan Çakır, Cristina Legido-Quigley, Madhav Thambisetty
Publikováno v:
npj Aging and Mechanisms of Disease, Vol 7, Iss 1, Pp 1-14 (2021)
Abstract The role of brain cholesterol metabolism in Alzheimer’s disease (AD) remains unclear. Peripheral and brain cholesterol levels are largely independent due to the impermeability of the blood brain barrier (BBB), highlighting the importance o
Externí odkaz:
https://doaj.org/article/9b5faa98d6754c758ecbe26dd59288c8
Autor:
Caroline Trumpff, Edward Owusu-Ansah, Hans-Ulrich Klein, Annie J. Lee, Vladislav Petyuk, Thomas S. Wingo, Aliza P. Wingo, Madhav Thambisetty, Luigi Ferrucci, Nicholas T. Seyfried, David A. Bennett, Philip L. De Jager, Martin Picard
Publikováno v:
Heliyon, Vol 8, Iss 5, Pp e09353- (2022)
Mitochondrial respiratory chain (RC) function requires the stoichiometric interaction among dozens of proteins but their co-regulation has not been defined in the human brain. Here, using quantitative proteomics across three independent cohorts we sy
Externí odkaz:
https://doaj.org/article/9f44588325f64b968b1c84d118e209d3
Autor:
Aliza P. Wingo, Eric B. Dammer, Michael S. Breen, Benjamin A. Logsdon, Duc M. Duong, Juan C. Troncosco, Madhav Thambisetty, Thomas G. Beach, Geidy E. Serrano, Eric M. Reiman, Richard J. Caselli, James J. Lah, Nicholas T. Seyfried, Allan I. Levey, Thomas S. Wingo
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Cognitive abilities tend to decline over time in advanced age, yet some individuals experience stable abilities or rapid decline. Here the authors present a proteome-wide association study of cognitive trajectory, and identify 38 proteins associated
Externí odkaz:
https://doaj.org/article/9b58a9346e234b21a9e82096eeb3d508
Autor:
Vijay R Varma, Youjin Wang, Yang An, Sudhir Varma, Murat Bilgel, Jimit Doshi, Cristina Legido-Quigley, João C Delgado, Anup M Oommen, Jackson A Roberts, Dean F Wong, Christos Davatzikos, Susan M Resnick, Juan C Troncoso, Olga Pletnikova, Richard O'Brien, Eelko Hak, Brenda N Baak, Ruth Pfeiffer, Priyanka Baloni, Siamak Mohmoudiandehkordi, Kwangsik Nho, Rima Kaddurah-Daouk, David A Bennett, Shahinaz M Gadalla, Madhav Thambisetty
Publikováno v:
PLoS Medicine, Vol 18, Iss 5, p e1003615 (2021)
BackgroundWhile Alzheimer disease (AD) and vascular dementia (VaD) may be accelerated by hypercholesterolemia, the mechanisms underlying this association are unclear. We tested whether dysregulation of cholesterol catabolism, through its conversion t
Externí odkaz:
https://doaj.org/article/2c8a7f7dbbcf4006bcc57756f0be9c11
Autor:
Lori L. Beason‐Held, Cailey I. Kerley, Shikha Chaganti, Abhay Moghekar, Madhav Thambisetty, Luigi Ferrucci, Susan M. Resnick, Bennett A. Landman
Publikováno v:
Annals of Neurology. 93:805-818
We examined medical records to determine health conditions associated with dementia at varied intervals prior to dementia diagnosis in participants from the Baltimore Longitudinal Study of Aging (BLSA).Data were available for 347 Alzheimer's disease
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea8228da779ffca17270b5d852d01c4d
https://doi.org/10.1002/ana.26584
https://doi.org/10.1002/ana.26584
Autor:
Qu Tian, Manuel Montero‐Odasso, Aron S. Buchman, Michelle M. Mielke, Sara Espinoza, Charles S. DeCarli, Anne B. Newman, Stephen B. Kritchevsky, George W. Rebok, Susan M. Resnick, Madhav Thambisetty, Joe Verghese, Luigi Ferrucci
Publikováno v:
Alzheimer's & Dementia. 19:1579-1586
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c2bdfbb20e3250fcf39f85782e7c955d
https://doi.org/10.1002/alz.12905
https://doi.org/10.1002/alz.12905
Autor:
Vijay R. Varma, Rishi J. Desai, Sheeja Navakkode, Lik-Wei Wong, Carlos Anerillas, Tina Loeffler, Irene Schilcher, Mufaddal Mahesri, Kristyn Chin, Daniel B. Horton, Seoyoung C. Kim, Tobias Gerhard, Jodi B. Segal, Sebastian Schneeweiss, Myriam Gorospe, Sreedharan Sajikumar, Madhav Thambisetty
Publikováno v:
Molecular Psychiatry. 28:1312-1326
We recently nominated cytokine signaling through the Janus-kinase–signal transducer and activator of transcription (JAK/STAT) pathway as a potential AD drug target. As hydroxychloroquine (HCQ) has recently been shown to inactivate STAT3, we hypothe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0fa84daf8efd2044d43e38d81342535d
https://doi.org/10.1038/s41380-022-01912-0
https://doi.org/10.1038/s41380-022-01912-0