Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Madhan Mohan Chandra Sekhar Jaggarapu"'
Autor:
Sahil Inamdar, Abhirami P. Suresh, Joslyn L. Mangal, Nathan D. Ng, Alison Sundem, Christopher Wu, Kelly Lintecum, Abhirami Thumsi, Taravat Khodaei, Michelle Halim, Nicole Appel, Madhan Mohan Chandra Sekhar Jaggarapu, Arezoo Esrafili, Jordan R. Yaron, Marion Curtis, Abhinav P. Acharya
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Abstract Inhibition of glycolysis in immune cells and cancer cells diminishes their activity, and thus combining immunotherapies with glycolytic inhibitors is challenging. Herein, a strategy is presented where glycolysis is inhibited in cancer cells
Externí odkaz:
https://doaj.org/article/1b742fa55db040f2888e0d48066e3a19
Autor:
Joslyn L. Mangal, Sahil Inamdar, Abhirami P. Suresh, Madhan Mohan Chandra Sekhar Jaggarapu, Arezoo Esrafili, Nathan D. Ng, Abhinav P. Acharya
Publikováno v:
Biomaterials Science. 10:6688-6697
Activated effector T cells induce pro-inflammatory responses in rheumatoid arthritis (RA) which then lead to inflammation of the joints. In this report, we demonstrate that polymeric nanoparticles with alpha keto-glutarate (aKG) in their polymer back
Autor:
Sahil Inamdar, Tina Tylek, Abhirami Thumsi, Abhirami P. Suresh, Madhan Mohan Chandra Sekhar Jaggarapu, Michelle Halim, Shivani Mantri, Arezoo Esrafili, Nathan D. Ng, Elizabeth Schmitzer, Kelly Lintecum, Camila de Ávila, John D. Fryer, Ying Xu, Kara L. Spiller, Abhinav P. Acharya
Publikováno v:
Biomaterials. 293:121973
Although different metabolic pathways have been associated with distinct macrophage phenotypes, the field of utilizing metabolites to modulate macrophage phenotype is in a nascent stage. In this report, we developed microparticles based on polymeriza
Autor:
Sudhakar Jinka, Bhowmira Rathore, Kathyayani Sridharan, Hari Krishna Reddy Rachamalla, Yousuf, Rajkumar Banerjee, Madhan Mohan Chandra Sekhar Jaggarapu
Publikováno v:
Molecular Pharmaceutics. 18:1208-1228
Hydrocortisone, a natural glucocorticoid secreted by adrenal and extra-adrenal tissues, locally governs the transcription of genes involved in inflammation, immune response, metabolism, and energy homeostasis via binding to its cognate glucocorticoid
Autor:
Chandra Kumar Elechalawar, Sumana Chakravarty, Muthusamy Eswaramoorthy, Piyush Chaturbedy, Rajkumar Banerjee, Kathyayani Sridharan, Halley Gora, Sarmistha Halder Sinha, Madhan Mohan Chandra Sekhar Jaggarapu, Mohammed Tanveer Ahmed, Dwaipayan Bhattacharya, Tapas K. Kundu, Kumar Pranav Narayan
Publikováno v:
Nanoscale advances. 1(9)
Glioblastoma multiforme (GBM), the highly invasive form of glioma, exhibits the highest mortality in patients with brain malignancies. Increasing glioma patients' survivability is challenging, as targeting only tumor-associated malignant cells would
Autor:
Bhowmira Rathore, Anirban Ganguly, Rajkumar Banerjee, Madhan Mohan Chandra Sekhar Jaggarapu, Hari Krishna Reddy Rachamalla
Publikováno v:
European Journal of Medicinal Chemistry. 108:309-321
Hydrocortisone, the endogenously expressed steroidal, hormonal ligand for glucocorticoid receptor (GR), is body's natural anti-inflammatory and xenobiotic metabolizing agent. It has both palliative as well as adverse effects in different cancer patie
Autor:
Madhan Mohan Chandra Sekhar Jaggarapu, Hari Krishna Reddy Rachamalla, Rajkumar Banerjee, Narendra Varma Nimmu
Publikováno v:
Journal of Drug Delivery Science and Technology. 58:101798
Cancer treatment necessitates targeted and efficient drug delivery to reduce drug-mediated adverse collateral effects. We develop herein a new liposomal delivery system which targets both CD13 receptor-positive cancer epithelial and angiogenic endoth