Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Madelyn Cueva"'
Autor:
Haritha Mathsyaraja, Benjamin Wolf, Chari Cortez, Adam Kashishian, Alison Karst, Madelyn Cueva, Min Wang, Kathleen S. Keegan, Jennifer Cain
Publikováno v:
Cancer Research. 82:2079-2079
Tumor cells employ mechanisms to evade anti-tumor immune responses that can include the downregulation or silencing of cytosolic nucleic acid sensing pathway components to dampen Type I IFN signaling. It has been documented that genomic instability a
Autor:
Kaustav Biswas, Ning Chen, Ji Ma, Xiaoning Zhao, Randall W. Hungate, Carl Davis, Jessica Able, Madelyn Cueva, James J. S. Treanor, Matthew P. Bourbeau, Samer Chmait, Paul E. Harrington, Dianna Lester-Zeiner, Roxanne Kunz, Jianxia Shi, Hang Chen, Jennifer R. Allen, Amy Porter, Kristin L. Andrews, Essa Hu, Jean Danao, Santosh Talreja, Thomas Kornecook
Publikováno v:
Journal of medicinal chemistry. 57(15)
We report the identification of a PDE10A clinical candidate by optimizing potency and in vivo efficacy of promising keto-benzimidazole leads 1 and 2. Significant increase in biochemical potency was observed when the saturated rings on morpholine 1 an
Publikováno v:
Biological psychiatry. 61(2)
Background Most antidepressant medications target central monoamine systems and are often characterized by limited efficacies and unwanted side effects. Thus, significant efforts are ongoing to identify novel targets for the treatment of depression.