Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Madeline M. Butler"'
Autor:
Robert Mckay, James L. Graham, Kimber L. Stanhope, Susan F. Murray, Michael M. Swarbrick, Peter J. Havel, Lynnetta Watts, Sheri L. Booten, Arthur A. Levin, Madeline M. Butler, Andrew A. Bremer, Brett P. Monia, Sanjay Bhanot
Publikováno v:
Endocrinology, vol 150, iss 4
Swarbrick, Michael M; Havel, Peter J; Levin, Arthur A; Bremer, Andrew A; Stanhope, Kimber L; Butler, Madeline; et al.(2009). Inhibition of protein tyrosine phosphatase-1B with antisense oligonucleotides improves insulin sensitivity and increases adiponectin concentrations in monkeys.. Endocrinology, 150(4), 1670-1679. doi: 10.1210/en.2008-0885. UC Davis: Retrieved from: http://www.escholarship.org/uc/item/4bv2f7q5
Swarbrick, Michael M; Havel, Peter J; Levin, Arthur A; Bremer, Andrew A; Stanhope, Kimber L; Butler, Madeline; et al.(2009). Inhibition of protein tyrosine phosphatase-1B with antisense oligonucleotides improves insulin sensitivity and increases adiponectin concentrations in monkeys.. Endocrinology, 150(4), 1670-1679. doi: 10.1210/en.2008-0885. UC Davis: Retrieved from: http://www.escholarship.org/uc/item/4bv2f7q5
Protein tyrosine phosphatase (PTP)-1B antagonizes insulin signaling and is a potential therapeutic target for insulin resistance associated with obesity and type 2 diabetes. To date, studies of PTP-1B have been limited by the availability of specific
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32359c0acfa743548982c6ddacb9f408
https://doi.org/10.1210/en.2008-0885
https://doi.org/10.1210/en.2008-0885
Autor:
Xiao-Ying Hua, A Moore, Madeline M. Butler, Tony L. Yaksh, Nicholas M. Dean, Susan F. Murray, S Malkmus
Publikováno v:
Neuroscience. 113:99-107
Protein kinase C isoforms including the alpha isozyme have been implicated in morphine tolerance. In the present study, we examined the effect of intrathecal delivery of an antisense oligonucleotide targeting rat protein kinase Calpha mRNA on the exp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4c46c570ae39924d25ed7ff92d416a3
https://doi.org/10.1016/s0306-4522(02)00157-4
https://doi.org/10.1016/s0306-4522(02)00157-4
Autor:
Leigh Frost, Cathy Berg, Jill E. Clampit, Brett P. Monia, Rebecca J. Gum, Roger G. Ulrich, Madeline M. Butler, Michael R. Jirousek, Cristina M. Rondinone, Paul E. Kroeger, James M. Trevillyan, Bradley A. Zinker, Jeffrey F. Waring, Regina M. Reilly
Publikováno v:
Diabetes. 51:2405-2411
Protein tyrosine phosphatase 1B (PTP1B) has been implicated as a negative regulator of insulin action. Overexpression of PTP1B protein has been observed in insulin-resistant states associated with obesity. Mice lacking a functional PTP1B gene exhibit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d9ceb226219b523b3f68e3b581c7157
https://doi.org/10.2337/diabetes.51.8.2405
https://doi.org/10.2337/diabetes.51.8.2405
Autor:
Sanjay Bhanot, Susan Murray, William A. Gaarde, Madeline M. Butler, Ian Popoff, Nicholas M. Dean, Donna Witchell, Robert Mckay, Brett P. Monia
Publikováno v:
Diabetes. 51:1028-1034
Signaling through the phosphatidylinositol 3′-kinase (PI3K) pathway is crucial for metabolic responses to insulin, and defects in PI3K signaling have been demonstrated in type 2 diabetes. PTEN (MMAC1) is a lipid/protein phosphatase that can negativ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a81389fe8cfa0fe490f9d009783a16da
https://doi.org/10.2337/diabetes.51.4.1028
https://doi.org/10.2337/diabetes.51.4.1028
Autor:
C.F. Bennett, Arthur A. Levin, B.I. Axelsson, P.M. Åberg, Madeline M. Butler, Richard S. Geary, Mark J. Graham, Mike V. Templin
Publikováno v:
Antisense and Nucleic Acid Drug Development. 10:359-368
Antisense oligonucleotides are currently being investigated for the treatment of a variety of diseases. Antisense drugs are being administered primarily by parenteral injection. To explore more convenient patient delivery methods, we have characteriz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af6df35ec5908e94bbacfd8e66b32169
https://doi.org/10.1089/oli.1.2000.10.359
https://doi.org/10.1089/oli.1.2000.10.359
Publikováno v:
Nucleosides and Nucleotides. 16:1761-1764
The distribution of phosphorothioate oligodeoxynucleotides (P=S ODN) in rodent tissues was studied in vivo using three histological methods: direct fluorescence microscopy; immunohistochemistry; and autoradiography. All three methods gave essentially
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::94e5b6a5c14ea96fdcd513453e6406e2
https://doi.org/10.1080/07328319708006272
https://doi.org/10.1080/07328319708006272
Publikováno v:
Oligonucleotides. 20(5)
This study sought to determine if antisense oligodeoxynucleotides would inhibit E-selectin expression, which mediates leukocyte adhesion on endothelial cells, otherwise induced by in vivo endotoxin challenge. Six antisense phosphorothioate oligodeoxy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8660bee048acc713c871e413f53cdd25
https://pubmed.ncbi.nlm.nih.gov/20977376
https://pubmed.ncbi.nlm.nih.gov/20977376
Autor:
Andrew M. Siwkowski, Edward Wancewicz, Muthiah Manoharan, Bruce Ross, Guillermo Vasquez, Henri Sasmor, Oscar L. Acevedo, Elena A. Lesnik, Brett P. Monia, Gopal B. Inamati, Lijiang Shen, Madeline M. Butler, Donna Witchell
Publikováno v:
Antisensenucleic acid drug development. 13(3)
Inclusion of C-5 propynyl pyrimidines in phosphorothioate antisense oligonucleotides (ASOs) has been shown to significantly increase their potency for inhibiting gene expression in vitro. This increased potency is believed to be the result of enhance
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1ca60af2d2f705441f801f46f48564c
https://pubmed.ncbi.nlm.nih.gov/12954113
https://pubmed.ncbi.nlm.nih.gov/12954113
Autor:
Susan Murray, Anne Flanigan, Brenda F. Baker, Andrew M. Siwkowski, Karen Madsen, Deborah Goodfellow, Madeline M. Butler, Sreekant Murthy, Kathleen Myers, Donna Witchell
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 304(1)
Tumor necrosis factor-alpha (TNF-alpha) is a key cytokine involved in the pathogenesis of inflammatory bowel disease. We have developed a second-generation antisense oligonucleotide (ISIS 25302) specific for murine TNF-alpha and have evaluated this o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b75aaa946fe085a0e429d6b831682ac
https://pubmed.ncbi.nlm.nih.gov/12490618
https://pubmed.ncbi.nlm.nih.gov/12490618
Publikováno v:
Antisense Drug Technology: Principles: Strategies, and Applications
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3eb829c6bc154f4ebb95ea4dff140ad2
https://doi.org/10.1201/9781420002546.pt3
https://doi.org/10.1201/9781420002546.pt3
