Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Madeline M Keenen"'
Autor:
Madeline M Keenen, David Brown, Lucy D Brennan, Roman Renger, Harrison Khoo, Christopher R Carlson, Bo Huang, Stephan W Grill, Geeta J Narlikar, Sy Redding
Publikováno v:
eLife, Vol 10 (2021)
In mammals, HP1-mediated heterochromatin forms positionally and mechanically stable genomic domains even though the component HP1 paralogs, HP1α, HP1β, and HP1γ, display rapid on-off dynamics. Here, we investigate whether phase-separation by HP1 p
Externí odkaz:
https://doaj.org/article/1e4bc5d189424ef491218ff0e4ff27e9
Autor:
Heather L Parrish, Caleb R Glassman, Madeline M Keenen, Neha R Deshpande, Matthew P Bronnimann, Michael S Kuhns
Publikováno v:
PLoS ONE, Vol 11, Iss 3, p e0150876 (2016)
Externí odkaz:
https://doaj.org/article/7effbf4322de4f2f945e7aa920a526a2
Autor:
Heather L Parrish, Caleb R Glassman, Madeline M Keenen, Neha R Deshpande, Matthew P Bronnimann, Michael S Kuhns
Publikováno v:
PLoS ONE, Vol 10, Iss 7, p e0132333 (2015)
CD4 interactions with class II major histocompatibility complex (MHC) molecules are essential for CD4+ T cell development, activation, and effector functions. While its association with p56lck (Lck), a Src kinase, is important for these functions CD4
Externí odkaz:
https://doaj.org/article/79b89e2d99744b9a8f4351238c1166a5
Phase separation of Polycomb-repressive complex 1 is governed by a charged disordered region of CBX2
Autor:
Christopher P. Davis, Sharon K. Marr, Gizem Rizki, Jongmin Kim, Madeline M. Keenen, Robert E. Kingston, Aaron J. Plys
Publikováno v:
Genes & Development. 33:799-813
Mammalian development requires effective mechanisms to repress genes whose expression would generate inappropriately specified cells. The Polycomb-repressive complex 1 (PRC1) family complexes are central to maintaining this repression. These include
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e410c823b7e111fd79922a2ab4ed8d49
https://doi.org/10.1101/gad.326488.119
https://doi.org/10.1101/gad.326488.119
Autor:
Roman Renger, Lucy D Brennan, Harrison Khoo, David Brown, Geeta J. Narlikar, Sy Redding, Christopher R. Carlson, Stephan W. Grill, Madeline M. Keenen, Bo Huang
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::23236ce4156104b7d649f6c7cc7d253c
https://doi.org/10.7554/elife.64563.sa2
https://doi.org/10.7554/elife.64563.sa2
Autor:
Stephan W. Grill, Harrison Khoo, Bo Huang, Lucy D Brennan, Madeline M. Keenen, David Brown, Christopher R. Carlson, Roman Renger, Geeta J. Narlikar, Sy Redding
In mammals HP1-mediated heterochromatin forms positionally and mechanically stable genomic domains even though the component HP1 paralogs, HP1α, HP1β, and HP1γ, display rapid on-off dynamics. Here we investigate whether phase-separation by HP1 pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::148cb88839e9e5766ece29d5b69a29ef
https://doi.org/10.1101/2020.10.30.362772
https://doi.org/10.1101/2020.10.30.362772
Publikováno v:
Methods Enzymol
The ability of the heterochromatin protein-1 (HP1) to phase separate into droplets suggests new mechanisms of gene organization in the cell nucleus. An accumulating body of work suggests that other nuclear proteins also display phase separation behav
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::473e3197c8605db8b664f0bc10b31420
https://pubmed.ncbi.nlm.nih.gov/30471698
https://pubmed.ncbi.nlm.nih.gov/30471698
Autor:
Christopher P. Davis, Gizem Rizki, Sharon K. Marr, Jongmin Kim, Madeline M. Keenen, Robert E. Kingston, Aaron J. Plys
SummaryMammalian development requires effective mechanisms to repress genes whose expression would generate inappropriately specified cells. The Polycomb Repressive Complex 1 (PRC1) family complexes are central to maintaining this repression1. These
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1bdb8af03d94b3e8189f615c149ae2b
Autor:
Geeta J. Narlikar, David A. Agard, Alma L. Burlingame, Madeline M. Keenen, Jonathan B. Johnston, Adam G. Larson, Sy Redding, Michael J. Trnka, Daniel Elnatan
Publikováno v:
Nature, vol 547, iss 7662
Nature
Nature
Gene silencing by heterochromatin is proposed to occur in part as a result of the ability of heterochromatin protein 1 (HP1) proteins to spread across large regions of the genome, compact the underlying chromatin and recruit diverse ligands. Here we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f5a703edd466f86d93bfe3e22dd1890
https://escholarship.org/uc/item/3vh8n30c
https://escholarship.org/uc/item/3vh8n30c
Publikováno v:
Biophysical Journal. 114:30a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4f32df09c1c953d89aa0c478264057bb
https://doi.org/10.1016/j.bpj.2017.11.209
https://doi.org/10.1016/j.bpj.2017.11.209