Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Madeline M Dekarske"'
Autor:
Gabriel L. Hendricks, Kiho Lee, Xiaowen Huang, Taylor P. A. Hari, Jenna Port, Frederick M. Ausubel, Madeline M Dekarske, Noelly Queiroz Ribeiro, Hammad A. Faizi, Jake L Rosen, Andrew D. Steele, Wen Pan, Beth Burgwyn Fuchs, Guijin Zou, William M. Wuest, Eleftherios Mylonakis, Wenpeng Zhu, Nicolas Galle, Erika E Csatary, Petia M. Vlahovska, Huajian Gao, Ingrid K. Wilt, Katerina Tori, Wooseong Kim
Publikováno v:
Proceedings of the National Academy of Sciences. 116:16529-16534
Treatment of Staphylococcus aureus infections is complicated by the development of antibiotic tolerance, a consequence of the ability of S. aureus to enter into a nongrowing, dormant state in which the organisms are referred to as persisters. We repo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::efc41c3b5b07eb24c9c9bbde7a6a55e4
https://doi.org/10.1073/pnas.1904700116
https://doi.org/10.1073/pnas.1904700116
Autor:
Madeline M, Dekarske, Lewis Oscar, Felix, Carlos Monteagudo, Ortiz, Erika E, Csatary, Elefterios, Mylonakis, William M, Wuest
Publikováno v:
Bioorg Med Chem Lett
nTZDpa kills both growing and persister Staphylococcus aureus. However, due to toxicity liabilities, our lab conducted two structure–activity relationship (SAR) studies focusing on the core scaffold and obtained a new lead compound that was more po
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0896ee2906feea4edc15e07c8944507
https://doi.org/10.1016/j.bmcl.2022.128678
https://doi.org/10.1016/j.bmcl.2022.128678
Autor:
Marcus Nowlan, Cristian Ochoa, Madeline M Dekarske, William M. Wuest, Amy E. Solinski, Marisa C. Kozlowski
Publikováno v:
ACS Infect Dis
Targeting Streptococcus mutans is the primary focus in reducing dental caries, one of the most common maladies in the world. Previously, our groups discovered a potent bactericidal biaryl compound that was inspired by the natural product honokiol. He
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79a246cf24862bb77b25fd2c4d3172ef
https://pubmed.ncbi.nlm.nih.gov/31663323
https://pubmed.ncbi.nlm.nih.gov/31663323
Autor:
Wooseong, Kim, Guijin, Zou, Taylor P A, Hari, Ingrid K, Wilt, Wenpeng, Zhu, Nicolas, Galle, Hammad A, Faizi, Gabriel L, Hendricks, Katerina, Tori, Wen, Pan, Xiaowen, Huang, Andrew D, Steele, Erika E, Csatary, Madeline M, Dekarske, Jake L, Rosen, Noelly de Queiroz, Ribeiro, Kiho, Lee, Jenna, Port, Beth Burgwyn, Fuchs, Petia M, Vlahovska, William M, Wuest, Huajian, Gao, Frederick M, Ausubel, Eleftherios, Mylonakis
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 116(33)
Treatment of Staphylococcus aureus infections is complicated by the development of antibiotic tolerance, a consequence of the ability of S. aureus to enter into a nongrowing, dormant state in which the organisms are referred to as persisters. We repo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ef3cb844a37d0fd07a5d583a031da77c
https://pubmed.ncbi.nlm.nih.gov/31358625
https://pubmed.ncbi.nlm.nih.gov/31358625
Autor:
Wooseong Kim, Nico Fricke, Huajian Gao, William M. Wuest, Erika E Csatary, Bumsup Kwon, Frederick M. Ausubel, Andrew D. Steele, Madeline M Dekarske, Elamparithi Jayamani, Wen Pan, Petia M. Vlahovska, Annie L. Conery, Wenpeng Zhu, Jake L Rosen, Beth Burgwyn Fuchs, Isabelle Sinitsa, Eleftherios Mylonakis
Conventional antibiotics are not effective in treating infections caused by drug-resistant or persistent nongrowing bacteria, creating a dire need for the development of new antibiotics. We report that the small molecule nTZDpa, previously characteri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99f0e34866439648dea6accbe29a166e
https://europepmc.org/articles/PMC6468991/
https://europepmc.org/articles/PMC6468991/
Publikováno v:
The Journal of organic chemistry. 83(11)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdfad3b468c8b15008f9c54036b8e433
https://pubmed.ncbi.nlm.nih.gov/29086565
https://pubmed.ncbi.nlm.nih.gov/29086565
Publikováno v:
The Journal of organic chemistry. 82(23)
The pentacyclic alkaloid calothrixin B (1) has been synthesized in 5 steps from murrayaquinone A (9). The key step involved the union of boryl aniline 31 with brominated murrayaquinone A (26). In this transformation, alkylquinone 26 undergoes tautome
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81ddf535867019fd79b3e9a4f7419999
https://pubmed.ncbi.nlm.nih.gov/29767515
https://pubmed.ncbi.nlm.nih.gov/29767515
Autor:
Santa Jansone-Popova, Vyacheslav S. Bryantsev, Ilja Popovs, Madeline M. Dekarske, Radu Custelcean, Bruce A. Moyer, Alexander S. Ivanov, Frederick V. Sloop
Publikováno v:
Inorganic chemistry. 56(10)
We report a new family of preorganized bis-lactam-1,10-phenanthroline (BLPhen) complexants that possess both hard and soft donor atoms within a convergent cavity and show unprecedented extraction strength for the trivalent f-block metal ions. BLPhen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::def4d6f7063f4299b61721f09c5d95be
https://pubmed.ncbi.nlm.nih.gov/28471188
https://pubmed.ncbi.nlm.nih.gov/28471188