Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Madeline J Price"'
Autor:
Christopher D. Scharer, Dillon G. Patterson, Tian Mi, Madeline J. Price, Sakeenah L. Hicks, Jeremy M. Boss
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
The development of activated B cells into antibody-secreting cells (ASC) is a critical step for humoral immunity. Here the authors show, using adoptive transfers and single cell RNA sequencing, that commitment to ASC occurs soon following B cell acti
Externí odkaz:
https://doaj.org/article/279286b32b4a46bfa72d332ce28e2321
Publikováno v:
Cell Reports, Vol 23, Iss 11, Pp 3152-3159 (2018)
Summary: Transitioning from a metabolically quiescent naive B cell to an antibody-secreting plasmablast requires division-dependent cellular differentiation. Though cell division demands significant ATP and metabolites, the metabolic processes used f
Externí odkaz:
https://doaj.org/article/09e41b60301b41b4a981eb4ac38ec6bd
Autor:
Benjamin G. Barwick, Christopher D. Scharer, Ryan J. Martinez, Madeline J. Price, Alexander N. Wein, Robert R. Haines, Alexander P. R. Bally, Jacob E. Kohlmeier, Jeremy M. Boss
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
DNA methylation is known to contribute to B cell differentiation, but de novo methylation has not been studied in this context. Here the authors use a conditional Dnmt3a/b knockout mouse to map the function of de novo DNA methylation in B cell differ
Externí odkaz:
https://doaj.org/article/33af14121bb04d5cbdd45624b424b0e7
Autor:
Christopher D. Scharer, James R. Rose, Madeline J. Price, Anna K. Kania, Jeremy M. Boss, Dillon G. Patterson
Publikováno v:
J Immunol
Cell division is an essential component of B cell differentiation to Ab-secreting plasma cells, with critical reprogramming occurring during the initial stages of B cell activation. However, a complete understanding of the factors that coordinate ear
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::295cc11b9b7abbe93a826fea021a83ea
https://doi.org/10.4049/jimmunol.2100440
https://doi.org/10.4049/jimmunol.2100440
Autor:
Anna K. Kania, Madeline J. Price, Lou-Ella George-Alexander, Dillon G. Patterson, Sakeenah L. Hicks, Christopher D. Scharer, Jeremy M. Boss
Publikováno v:
J Immunol
B cell differentiation is associated with substantial transcriptional, metabolic, and epigenetic remodeling, including redistribution of histone 3 lysine 27 trimethylation (H3K27me3), which is associated with a repressive chromatin state and gene sil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e31bf75340854ccc07015a3a9e912776
https://pubmed.ncbi.nlm.nih.gov/35346967
https://pubmed.ncbi.nlm.nih.gov/35346967
Autor:
Jeremy M. Boss, Anna K. Kania, Madeline J. Price, Christopher D. Scharer, James R. Rose, Dillon G. Patterson
Cell division is an essential component of B cell differentiation to antibody-secreting plasma cells, with critical reprogramming occurring during the initial stages of B cell activation. However, a complete understanding of the factors that coordina
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::547e49cfcee74ed51e680df386da520a
https://doi.org/10.1101/2021.06.20.449155
https://doi.org/10.1101/2021.06.20.449155
Memory B cells (MBCs) have enhanced capabilities to differentiate to plasma cells and generate a rapid burst of antibodies upon secondary stimulation. To determine if MBCs harbor an epigenetic landscape that contributes to increased differentiation p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32ffdcbe4728f32442c5abee4a2d5709
https://doi.org/10.1101/2021.01.20.427446
https://doi.org/10.1101/2021.01.20.427446
Autor:
Madeline J. Price, Christopher D. Scharer, Tian Mi, Jeremy M. Boss, Sakeenah L. Hicks, Dillon G. Patterson
Publikováno v:
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Upon stimulation, B cells assume heterogeneous cell fates, with only a fraction differentiating into antibody-secreting cells (ASC). Here we investigate B cell fate programming and heterogeneity during ASC differentiation using T cell-independent mod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd0bf8e7311aa4aed3c3632c618f6827
http://europepmc.org/articles/PMC7417592
http://europepmc.org/articles/PMC7417592
Autor:
Christopher D. Scharer, Jeremy M. Boss, John E. Bradley, Madeline J. Price, Troy D. Randall, Sakeenah L. Hicks
Publikováno v:
J Immunol
Ab-secreting cells (ASC) or plasma cells are essential components of the humoral immune system. Although Abs of different isotypes have distinct functions, it is not known if the ASC that secrete each isotype are also distinct. ASC downregulate their
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91eae6e0b5c0b2038b138555490e8167
https://pubmed.ncbi.nlm.nih.gov/31501259
https://pubmed.ncbi.nlm.nih.gov/31501259
Autor:
Sakeenah L. Hicks, Christopher D. Scharer, Madeline J. Price, Jeremy M. Boss, Dillon G. Patterson, Tian Mi
Publikováno v:
Cancer Immunology Research. 8:A74-A74
Plasma cells engineered to produce and secrete de novo proteins have the potential to be used as biologic therapeutics for the treatment of cancer and other diseases. Genetic manipulation, expansion, and differentiation of naive B cells has been perf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::124648619ed6659e1151692a165273dd
https://doi.org/10.1158/2326-6074.tumimm19-a74
https://doi.org/10.1158/2326-6074.tumimm19-a74