A Modified Cell-Penetrating Peptide Enhances Insulin and Oxytocin Delivery across an RPMI 2650 Nasal Epithelial Cell Barrier In Vitro

Autor: Sara Wong, Alexander D. Brown, Abigail B. Abrahams, An Nisaa Nurzak, Hoda M. Eltaher, David A. Sykes, Dmitry B. Veprintsev, Kevin C. F. Fone, James E. Dixon, Madeleine V. King

Publikováno v: Pharmaceutics, Vol 16, Iss 10, p 1267 (2024)

Background/Objectives: Peptide-based treatments represent an expanding area and require innovative approaches to enhance bioavailability. Combination with cell-penetrating peptides (CPPs) is an attractive strategy to improve non-invasive delivery acr

Externí odkaz: https://doaj.org/article/46e3a3fb62ff4c11b57c91f0106aeaf4

Gestational poly(I:C) attenuates, not exacerbates, the behavioral, cytokine and mTOR changes caused by isolation rearing in a rat ‘dual-hit’ model for neurodevelopmental disorders

Autor: Saoirse E. O'Sullivan, Jen-Yin Goh, Kevin C. F. Fone, Madeleine V. King, Harry G. Potter, S.E. Shortall, Nicole Zordan, Anna M. Piccinini

Publikováno v: Goh, J-Y, O'Sullivan, S E, Shortall, S E, Zordan, N, Piccinini, A M, Potter, H, Fone, K C F & King, M V 2020, ' Gestational poly(I:C) attenuates, not exacerbates, the behavioral, cytokine and mTOR changes caused by isolation rearing in a rat ‘dual-hit’ model for neurodevelopmental disorders ', Brain, Behavior, and Immunity . https://doi.org/10.1016/j.bbi.2020.05.076

Many psychiatric illnesses have a multifactorial etiology involving genetic and environmental risk factors that trigger persistent neurodevelopmental impairments. Several risk factors have been individually replicated in rodents, to understand diseas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57cb545235998851083241c1545106e6
https://doi.org/10.1016/j.bbi.2020.05.076

P.083 Peripheral oxytocin administration increases social interaction in the rat through activity at nucleus accumbens oxytocin receptors

Autor: Madeleine V. King, K.C.F. Fone, A.B. Abrahams, S. Wong, D.J. Watson

Publikováno v: European Neuropsychopharmacology. 40:S54-S55

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7e56387bae13cece22ef5e72b78b9f16
https://doi.org/10.1016/j.euroneuro.2020.09.075

Contribution of serotonin and dopamine to changes in core body temperature and locomotor activity in rats following repeated administration of mephedrone

Autor: S.E. Shortall, Francis J. P. Ebling, Madeleine V. King, Kevin C. F. Fone, Clare H. Spicer, A. Richard Green

Publikováno v: Addiction Biology. 21:1127-1139

The psychoactive effects of mephedrone are commonly compared with those of 3,4-methylenedioxymethamphetamine, but because of a shorter duration of action, users often employ repeated administration to maintain its psychoactive effects. This study exa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e31e9b7d4348cff6efa8dfead9d07b63
https://doi.org/10.1111/adb.12283

Impact of cafeteria feeding during lactation in the rat on novel object discrimination in the offspring

Autor: William G. Davey, Simon C. Langley-Evans, Madeleine V. King, Jörg-Peter W. Voigt, Thomas M. Wright

Publikováno v: British Journal of Nutrition. 112:1933-1937

There is increasing evidence that hyperenergetic diets have an impact on memory in rodents. However, it is largely unknown how diets, such as a cafeteria diet (CD), that mimic a Western-type diet act on learning and memory, in particular when fed dur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::312a2c848f5535764b54bafddb75c821
https://doi.org/10.1017/s0007114514003134