Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Madeleine Speck"'
Autor:
Isaac Rosado-Sánchez, Manjurul Haque, Kevin Salim, Madeleine Speck, Vivian C.W. Fung, Dominic A. Boardman, Majid Mojibian, Giorgio Raimondi, Megan K. Levings
Publikováno v:
JCI Insight, Vol 8, Iss 19 (2023)
Tregs expressing chimeric antigen receptors (CAR-Tregs) are a promising tool to promote transplant tolerance. The relationship between CAR structure and Treg function was studied in xenogeneic, immunodeficient mice, revealing advantages of CD28-encod
Externí odkaz:
https://doaj.org/article/cf2c48e413f44ef8a6d17ff698bc1b5b
Autor:
Dominika Nackiewicz, Meixia Dan, Madeleine Speck, Samuel Z. Chow, Yi-Chun Chen, J. Andrew Pospisilik, C. Bruce Verchere, Jan A. Ehses
Publikováno v:
iScience, Vol 23, Iss 1, Pp - (2020)
Summary: Macrophages play a dynamic role in tissue repair following injury. Here we found that following streptozotocin (STZ)-induced beta-cell death, mouse islet macrophages had increased Igf1 expression, decreased proinflammatory cytokine expressio
Externí odkaz:
https://doaj.org/article/185474ae2b97478a94b428034c20b27a
Autor:
Isaac Rosado-Sánchez, Manjurul Haque, Kevin Salim, Madeleine Speck, Vivian Fung, Dominic Boardman, Majid Mojibian, Giorgio Raimondi, Megan K Levings
Regulatory T cells (Tregs) expressing chimeric antigen receptors (CAR) are a promising tool to promote transplant tolerance. The relationship between CAR structure and Treg function was studied in xenogeneic, immunodeficient mice, revealing advantage
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::569d3c8d5eb087dbc241e2a78ee224c8
https://doi.org/10.1101/2022.11.10.516049
https://doi.org/10.1101/2022.11.10.516049
Autor:
null Avery J. Lam, null Manjurul Haque, null Kirsten A. Ward‐Hartstonge, null Prakruti Uday, null Christine M. Wardell, null Jana K. Gillies, null Madeleine Speck, null Majid Mojibian, null Ramon I. Klein Geltink, null Megan K. Levings
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53a00435ed284e5b2b8fed5fdb5a48a5
https://doi.org/10.1002/eji.202249888/v3/response1
https://doi.org/10.1002/eji.202249888/v3/response1
Autor:
Avery J. Lam, Manjurul Haque, Kirsten A. Ward-Hartstonge, Prakruti Uday, Christine M. Wardell, Jana K. Gillies, Madeleine Speck, Majid Mojibian, Ramon I. Klein Geltink, Megan K. Levings
Regulatory T cell (Treg) therapy is under clinical investigation for the treatment of transplant rejection, autoimmune disease, and graft-versus-host disease. With the advent of genome editing, attention has turned to reinforcing Treg function for th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5e13a459671c19adc4b4ca6174f8cf63
https://doi.org/10.1101/2022.03.06.483188
https://doi.org/10.1101/2022.03.06.483188
Autor:
Madeleine Speck, Caroline Lamarche, Megan K. Levings, May Wong, Isaac Rosado-Sánchez, Antoine Sicard, Nicolas Glaichenhaus, Majid Mojibian, Mathilde Blois
Publikováno v:
American Journal of Transplantation
Cell therapy with autologous donor-specific regulatory T cells (Tregs) is a promising strategy to minimize immunosuppression in transplant recipients. Chimeric antigen receptor (CAR) technology has recently been used successfully to generate donor-sp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e058907af6dfe810bec2f00579eaa0b9
https://doi.org/10.1111/ajt.15787
https://doi.org/10.1111/ajt.15787
Autor:
Jana Gillies, Qing Huang, Isaac Rosado-Sánchez, Emma McIver, Paul C. Orban, Megan K. Levings, Madeleine Speck, Nicholas A.J. Dawson, Grace Sun, Vivian C.W. Fung, Majid Mojibian, German E. Novakovsky
Publikováno v:
Science translational medicine. 12(557)
Antigen-specific regulatory T cells (Tregs) engineered with chimeric antigen receptors (CARs) are a potent immunosuppressive cellular therapy in multiple disease models and could overcome shortcomings of polyclonal Treg therapy. CAR therapy was initi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eccbc306d3720bbc94f5483c54cdf8b1
https://pubmed.ncbi.nlm.nih.gov/32817364
https://pubmed.ncbi.nlm.nih.gov/32817364
Autor:
Megan K. Levings, Madeleine Speck, Nicholas A.J. Dawson, Vivian C.W. Fung, German E. Novakovsky, Emma McIver, Majid Mojibian, Qing Huang, Grace Sun, Paul C. Orban, Jana Gillies, Isaac Rosado-Sánchez
SummaryAntigen-specific regulatory T cells (Tregs) engineered with chimeric antigen receptor (CARs) are a potent immunosuppressive cellular therapy in multiple disease models. To date the majority of CAR Treg studies employed second generation CARs,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3c0cd89dea68b3e90cc07b5f8030a8f
Autor:
Jonathan W. Bush, Jana Gillies, Madeleine Speck, Qing Huang, Megan K. Levings, Romy E. Hoeppli, Nicholas A.J. Dawson, Paul C. Orban, Caroline Lamarche, Emma McIver, Peter Bergqvist, Vivian C.W. Fung, Majid Mojibian
Publikováno v:
JCI Insight.
Chimeric antigen receptor (CAR) technology can be used to engineer the antigen specificity of regulatory T cells (Tregs) and improve their potency as an adoptive cell therapy in multiple disease models. As synthetic receptors, CARs carry the risk of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c4c7e638a5ec8196a5d0aa00c27312f
https://doi.org/10.1172/jci.insight.123672
https://doi.org/10.1172/jci.insight.123672
Autor:
Jan A. Ehses, Meixia Dan, J. Andrew Pospisilik, Yi-Chun Chen, Samuel Z. Chow, C. Bruce Verchere, Madeleine Speck, Dominika Nackiewicz
Publikováno v:
iScience, Vol 23, Iss 1, Pp-(2020)
iScience
iScience, 23 (1)
iScience
iScience, 23 (1)
Summary Macrophages play a dynamic role in tissue repair following injury. Here we found that following streptozotocin (STZ)-induced beta-cell death, mouse islet macrophages had increased Igf1 expression, decreased proinflammatory cytokine expression
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16e8d9673e62e76c5af766e1d67ac9df
https://doi.org/10.1016/j.isci.2019.100775
https://doi.org/10.1016/j.isci.2019.100775