Zobrazeno 1 - 5
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pro vyhledávání: '"Madeleine S. Gastonguay"'
Publikováno v:
PLoS Genetics, Vol 18, Iss 5, p e1010184 (2022)
Genetic studies often seek to establish a causal chain of events originating from genetic variation through to molecular and clinical phenotypes. When multiple phenotypes share a common genetic association, one phenotype may act as an intermediate fo
Externí odkaz:
https://doaj.org/article/72d0915fdb7d445a88a4acb36baf78d9
Publikováno v:
GENETICS. 224
Mediation analysis is used in genetic mapping studies to identify candidate gene mediators of quantitative trait loci (QTL). We consider genetic mediation analysis of triplets—sets of three variables consisting of a target trait, the genotype at a
Autor:
Madeleine S Gastonguay, Gregory R. Keele, Wesley L. Crouse, William Valdar, Gary A. Churchill
Publikováno v:
PLOS Genetics. 18:e1010184
Genetic studies often seek to establish a causal chain of events originating from genetic variation through to molecular and clinical phenotypes. When multiple phenotypes share a common genetic association, one phenotype may act as an intermediate fo
Autor:
Sean Russell, Ahmed Elmokadem, Madeleine S Gastonguay, Matthew M Riggs, Reed Freling, Kiersten Utsey
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 48(10)
Tissue:plasma partition coefficients are key parameters in physiologically based pharmacokinetic (PBPK) models, yet the coefficients are challenging to measure in vivo. Several mechanistic-based equations have been developed to predict partition coef
Autor:
Hakon Hakonarson, Jonathan P. Bradfield, Madeleine S Gastonguay, Athena F. Zuppa, Marc R. Gastonguay, Nicole R. Zane, Ganesh S. Moorthy, Martha A. Q. Curley, Daniela J Conrado, Janice L. Prodell
Publikováno v:
Critical care medicine. 47(6)
To develop a pharmacokinetic-pharmacogenomic population model of midazolam in critically ill children with primary respiratory failure.Prospective pharmacokinetic-pharmacogenomic observational study.Thirteen PICUs across the United States.Pediatric s