Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Madeleine P. J. White"'
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-14 (2024)
Abstract The adaptability of glioblastoma (GBM) cells, encouraged by complex interactions with the tumour microenvironment (TME), currently renders GBM an incurable cancer. Despite intensive research, with many clinical trials, GBM patients rely on s
Externí odkaz:
https://doaj.org/article/e7e4e6c2f4ec42e0acf2fa0cb7cc91e3
Autor:
Bergithe E. Oftedal, Stefano Maio, Adam E. Handel, Madeleine P. J. White, Duncan Howie, Simon Davis, Nicolas Prevot, Ioanna A. Rota, Mary E. Deadman, Benedikt M. Kessler, Roman Fischer, Nikolaus S. Trede, Erdinc Sezgin, Rick M. Maizels, Georg A. Holländer
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
Oftedal et al. generate mice lacking the chaperonin subunit CCT8 in T cells. They find that loss of CCT8 leads to reduced formation of nuclear actin filaments, changes in proteostasis, defective Th2 cell polarization and T cell metabolism and a faile
Externí odkaz:
https://doaj.org/article/f3b7f22ef77541f089085a26cdea4934
Autor:
Madeleine P. J. White, Chris J. C. Johnston, John R. Grainger, Joanne E. Konkel, Richard A. O'Connor, Stephen M. Anderton, Rick M. Maizels
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Helminth parasites are effective in biasing Th2 immunity and inducing regulatory pathways that minimize excessive inflammation within their hosts, thus allowing chronic infection to occur whilst also suppressing bystander atopic or autoimmune disease
Externí odkaz:
https://doaj.org/article/44678ea415b2410ba3cc2dbfdfecedc5
Autor:
Chris J. C. Johnston, Danielle J. Smyth, Ravindra B. Kodali, Madeleine P. J. White, Yvonne Harcus, Kara J. Filbey, James P. Hewitson, Cynthia S. Hinck, Alasdair Ivens, Andrea M. Kemter, Anna O. Kildemoes, Thierry Le Bihan, Dinesh C. Soares, Stephen M. Anderton, Thomas Brenn, Stephen J. Wigmore, Hannah V. Woodcock, Rachel C. Chambers, Andrew P. Hinck, Henry J. McSorley, Rick M. Maizels
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Heligmosomoides polygyrus can activate mammalian TGF-β signalling pathways, but how it does so is not known. Here the authors identify and isolate a H. polygyrus TFG-β mimic that can bind both mammalian TGF-β receptor subunits, activate Smad signa
Externí odkaz:
https://doaj.org/article/8966a9c3f97c4921a792b74844b1800f
Autor:
Danielle J Smyth, Madeleine P J White, Chris J C Johnston, Anne-Marie Donachie, Marta Campillo Poveda, Henry J McSorley, Rick M Maizels
Publikováno v:
Discovery Immunology. 2
In animal models of inflammatory colitis, pathology can be ameliorated by several intestinal helminth parasites, including the mouse nematode Heligmosomoides polygyrus. To identify parasite products that may exert anti-inflammatory effects in vivo, w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2fcd2421999a5086e3894c33c345c8a9
https://doi.org/10.1093/discim/kyad001
https://doi.org/10.1093/discim/kyad001
Autor:
Danielle J. Smyth, Megan K. Levings, Laura Cook, Madeleine P. J. White, Steven F. Ziegler, Rick M. Maizels
Publikováno v:
Immunology & Cell Biology. 99:848-864
Transforming growth factor-beta (TGF-β) family proteins mediate many vital biological functions in growth, development and regulation of the immune system. TGF-β itself controls immune homeostasis and inflammation, including conversion of naive CD4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf014778ff2c35c3be69cff98ee8d148
https://doi.org/10.1111/imcb.12479
https://doi.org/10.1111/imcb.12479
Autor:
Steven F. Ziegler, Jana Gillies, Laura Cook, Shigeru Tanaka, Kyle T Reid, Danielle J. Smyth, Madeleine P. J. White, Elmeri Hakkinen, Qing Huang, Brett de Bie, May Q. Wong, Megan K. Levings, Rick M. Maizels
Publikováno v:
Immunology and Cell Biology
Immune homeostasis in the intestine is tightly controlled by FOXP3+ regulatory T cells (Tregs), defects of which are linked to the development of chronic conditions, such as inflammatory bowel disease (IBD). As a mechanism of immune evasion, several
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a445c9bf182130405d4bb0a8e794e40e
http://europepmc.org/articles/PMC8453874
http://europepmc.org/articles/PMC8453874
Publikováno v:
Immunology
Summary Helminth parasites infect an alarmingly large proportion of the world's population, primarily within tropical regions, and their ability to down‐modulate host immunity is key to their persistence. Helminths have developed multiple mechanism
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c92f833261c669359a0a9ecba9152401
https://doi.org/10.1111/imm.13190
https://doi.org/10.1111/imm.13190
Autor:
Bijie Ren, Jagroop Pandhal, Stephen P. Mayfield, Francis J. Fields, Caitlin M. McManus, Vivien Shek, Madeleine P. J. White, Caroline A. Evans, Danielle J. Smyth, Rick M. Maizels, Holly Webster
Publikováno v:
Journal of Biotechnology
Inflammatory bowel disease (IBD) is a set of immunological disorders which can generate chronic pain and fatigue associated with the inflammatory symptoms. The treatment of IBD remains a significant hurdle with current therapies being only partially
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d8ea7866401d33706af814c95c186fc
https://escholarship.org/uc/item/9wd8z662
https://escholarship.org/uc/item/9wd8z662
Autor:
Chris J. C. Johnston, Madeleine P. J. White, Joanne E. Konkel, Stephen M. Anderton, John R. Grainger, Rick M. Maizels, Richard A. O’Connor
Publikováno v:
Frontiers in Immunology
White, M P J, Johnston, C J C, Grainger, J R, Konkel, J E, O'Connor, R A, Anderton, S M & Maizels, R M 2020, ' The helminth parasite heligmosomoides polygyrus attenuates EAE in an IL-4Rα-dependent manner ', Frontiers in Immunology, vol. 11, 1830 . https://doi.org/10.3389/fimmu.2020.01830
Frontiers in Immunology, Vol 11 (2020)
White, M P J, Johnston, C J C, Grainger, J R, Konkel, J E, O'Connor, R A, Anderton, S M & Maizels, R M 2020, ' The helminth parasite heligmosomoides polygyrus attenuates EAE in an IL-4Rα-dependent manner ', Frontiers in Immunology, vol. 11, 1830 . https://doi.org/10.3389/fimmu.2020.01830
Frontiers in Immunology, Vol 11 (2020)
Helminth parasites are effective in biasing Th2 immunity and inducing regulatory pathways that minimize excessive inflammation within their hosts, thus allowing chronic infection to occur whilst also suppressing bystander atopic or autoimmune disease
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5b938b4198e20ebf5772fb2c938116c