Data from Selective Alanine Transporter Utilization Creates a Targetable Metabolic Niche in Pancreatic Cancer

Autor: Alec C. Kimmelman, Joseph D. Mancias, Dafna Bar-Sagi, Mark R. Philips, Huamin Wang, Drew R. Jones, Steven P. Gygi, Joao A. Paulo, Doug E. Biancur, Albert S.W. Sohn, Madeleine M. LaRue, Rebecca E. Rose, Joel Encarnación-Rosado, Keisuke Yamamoto, Qijia Yu, Kate E.R. Hollinshead, Caroline R. Amendola, Seth J. Parker

Pancreatic ductal adenocarcinoma (PDAC) evolves a complex microenvironment comprised of multiple cell types, including pancreatic stellate cells (PSC). Previous studies have demonstrated that stromal supply of alanine, lipids, and nucleotides support

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::09d4144fd59409f3ac6db0c6f0233288
https://doi.org/10.1158/2159-8290.c.6547766.v1

Selective Alanine Transporter Utilization Creates a Targetable Metabolic Niche in Pancreatic Cancer

Autor: Joseph D. Mancias, Seth J. Parker, Mark R. Philips, Drew R. Jones, Alec C. Kimmelman, Doug E. Biancur, Steven P. Gygi, Joao A. Paulo, Qijia Yu, Albert S. W. Sohn, Kate E.R. Hollinshead, Keisuke Yamamoto, Rebecca E. Rose, Joel Encarnación-Rosado, Madeleine M. LaRue, Caroline R. Amendola, Huamin Wang, Dafna Bar-Sagi

Publikováno v: Cancer Discov

Pancreatic ductal adenocarcinoma (PDAC) evolves a complex microenvironment comprised of multiple cell types, including pancreatic stellate cells (PSC). Previous studies have demonstrated that stromal supply of alanine, lipids, and nucleotides support

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c91019722e5bddd9dc300472d58443e1
https://doi.org/10.1158/2159-8290.cd-19-0959

Route of self-amplifying mRNA vaccination modulates the establishment of pulmonary resident memory CD8 and CD4 T cells.

Autor: Künzli M; Center for Immunology, Department of Microbiology and Immunology, University of Minnesota, Minneapolis, MN, USA., O'Flanagan SD; Center for Immunology, Department of Microbiology and Immunology, University of Minnesota, Minneapolis, MN, USA., LaRue M; Center for Immunology, Department of Microbiology and Immunology, University of Minnesota, Minneapolis, MN, USA., Talukder P; Tiba Biotech LLC, Cambridge, MA, USA., Dileepan T; Center for Immunology, Department of Microbiology and Immunology, University of Minnesota, Minneapolis, MN, USA., Stolley JM; Center for Immunology, Department of Microbiology and Immunology, University of Minnesota, Minneapolis, MN, USA., Soerens AG; Center for Immunology, Department of Microbiology and Immunology, University of Minnesota, Minneapolis, MN, USA., Quarnstrom CF; Center for Immunology, Department of Microbiology and Immunology, University of Minnesota, Minneapolis, MN, USA., Wijeyesinghe S; Center for Immunology, Department of Microbiology and Immunology, University of Minnesota, Minneapolis, MN, USA., Ye Y; Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA, USA., McPartlan JS; Tiba Biotech LLC, Cambridge, MA, USA., Mitchell JS; Center for Immunology, Department of Microbiology and Immunology, University of Minnesota, Minneapolis, MN, USA., Mandl CW; Tiba Biotech LLC, Cambridge, MA, USA., Vile R; Department of Molecular Medicine, Mayo Clinic, Rochester, MN, USA., Jenkins MK; Center for Immunology, Department of Microbiology and Immunology, University of Minnesota, Minneapolis, MN, USA., Ahmed R; Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA, USA., Vezys V; Center for Immunology, Department of Microbiology and Immunology, University of Minnesota, Minneapolis, MN, USA., Chahal JS; Tiba Biotech LLC, Cambridge, MA, USA., Masopust D; Center for Immunology, Department of Microbiology and Immunology, University of Minnesota, Minneapolis, MN, USA.

Publikováno v: Science immunology [Sci Immunol] 2022 Dec 09; Vol. 7 (78), pp. eadd3075. Date of Electronic Publication: 2022 Dec 02.