Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Madeleine K D Scott"'
Autor:
Audrey Lee, Madeleine K. D. Scott, Florian Wimmers, Prabhu S. Arunachalam, Wei Luo, Christopher B. Fox, Mark Tomai, Purvesh Khatri, Bali Pulendran
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
Adjuvants provide additional impetus for the immune response to vaccination regimens, however their modes of activity and impact on particular compartments of the immune response are currently not well understood. Here the authors perform high resolu
Externí odkaz:
https://doaj.org/article/c4581bcc26564fe192f49148678f0969
Autor:
Prabhu S. Arunachalam, Madeleine K. D. Scott, Thomas Hagan, Chunfeng Li, Yupeng Feng, Florian Wimmers, Lilit Grigoryan, Meera Trisal, Venkata Viswanadh Edara, Lilin Lai, Sarah Esther Chang, Allan Feng, Shaurya Dhingra, Mihir Shah, Alexandra S. Lee, Sharon Chinthrajah, Sayantani B. Sindher, Vamsee Mallajosyula, Fei Gao, Natalia Sigal, Sangeeta Kowli, Sheena Gupta, Kathryn Pellegrini, Gregory Tharp, Sofia Maysel-Auslender, Sydney Hamilton, Hadj Aoued, Kevin Hrusovsky, Mark Roskey, Steven E. Bosinger, Holden T. Maecker, Scott D. Boyd, Mark M. Davis, Paul J. Utz, Mehul S. Suthar, Purvesh Khatri, Kari C. Nadeau, Bali Pulendran
Publikováno v:
Nature.
Autor:
Nigam H. Shah, Lawrence Bai, Laurynas Kalesinskas, Madeleine K D Scott, Ethan Steinberg, Aida Habtezion, Purvesh Khatri
Publikováno v:
Journal of the American Medical Informatics Association : JAMIA
Objective Ulcerative colitis (UC) is a chronic inflammatory disorder with limited effective therapeutic options for long-term treatment and disease maintenance. We hypothesized that a multi-cohort analysis of independent cohorts representing real-wor
Autor:
Meera Trisal, Prabhu S. Arunachalam, Bali Pulendran, Thomas Hagan, Allan Feng, Lilit Grigoryan, Natalia Sigal, Sheena Gupta, Kathryn L. Pellegrini, Mark Roskey, Kari C. Nadeau, Sarah Esther Chang, Steven E. Bosinger, Mehul S. Suthar, Sharon Chinthrajah, Venkata Viswanadh Edara, Mihir Shah, Mark M. Davis, Vamsee Mallajosyula, Fei Gao, Sayantani B. Sindher, Florian Wimmers, Yupeng Feng, Scott D. Boyd, Alexandra S. Lee, Holden T. Maecker, Sydney Hamilton, Chunfeng Li, Madeleine K D Scott, Lilin Lai, Purvesh Khatri, Sofia Maysel-Auslender, Shaurya Dhingra, Hadj Aoued, Paul J. Utz, Sangeeta Kowli, Gregory K. Tharp, Kevin Hrusovsky
Publikováno v:
Nature. 596:410-416
The emergency use authorization of two mRNA vaccines in less than a year from the emergence of SARS-CoV-2 represents a landmark in vaccinology1,2. Yet, how mRNA vaccines stimulate the immune system to elicit protective immune responses is unknown. He
Autor:
Traci Legere, Pradeep B. J. Reddy, Korey A. Walter, Bali Pulendran, Prabhu S. Arunachalam, Shankar Subramaniam, Florian Wimmers, Madeleine K D Scott, Celia C. LaBranche, Bertrand Z. Yeung, John P. Vasilakos, Venkata S. Bollimpelli, Samantha L. Burton, Sailaja Gangadhara, Sudhir Pai Kasturi, Shakti Gupta, Cynthia A. Derdeyn, Caroline Petitdemange, Pamela A. Kozlowski, David C. Montefiori, Tiffany M. Styles, Thomas J. Ketas, John P. Moore, Chil Yong Kang, Rama Rao Amara, Eric Hunter, George M. Shaw, Purvesh Khatri, Mark A. Tomai, Anthony Tsai, David Masopust, Vineet Joag, Clare F. Quarnstrom, Tysheena P. Charles
Publikováno v:
Nature Medicine
Recent efforts toward an HIV vaccine focus on inducing broadly neutralizing antibodies, but eliciting both neutralizing antibodies (nAbs) and cellular responses may be superior. Here, we immunized macaques with an HIV envelope trimer, either alone to
Autor:
Chunfeng Li, Audrey Lee, Lilit Grigoryan, Prabhu S. Arunachalam, Madeleine K. D. Scott, Meera Trisal, Florian Wimmers, Mrinmoy Sanyal, Payton A. Weidenbacher, Yupeng Feng, Julia Z. Adamska, Erika Valore, Yanli Wang, Rohit Verma, Noah Reis, Diane Dunham, Ruth O’Hara, Helen Park, Wei Luo, Alexander D. Gitlin, Peter Kim, Purvesh Khatri, Kari C. Nadeau, Bali Pulendran
Publikováno v:
Nature immunology. 23(4)
Despite the success of the BNT162b2 mRNA vaccine, the immunological mechanisms that underlie its efficacy are poorly understood. Here we analyzed the innate and adaptive responses to BNT162b2 in mice, and show that immunization stimulated potent anti
Autor:
Jessika Baral, Joshua C. Denny, Katie J. Quinn, Francesco Vallania, Jonathan A. Kropski, Kimberly Koloms, Robert J. Carroll, Hayley Warsinske, Monique Hinchcliff, Erica L. Herzog, Naftali Kaminski, Jongmin Lee, Jose D. Herazo-Maya, Mary Carns, Shirley Chen, Madeleine K D Scott, Jiehuan Sun, Kathleen Aren, Purvesh Khatri, Nigam H. Shah, Hongyu Zhao, Qin Li, Fernando J. Martinez, Bethany B. Moore
Publikováno v:
The Lancet. Respiratory Medicine
Summary Background There is an urgent need for biomarkers to better stratify patients with idiopathic pulmonary fibrosis by risk for lung transplantation allocation who have the same clinical presentation. We aimed to investigate whether a specific i
Autor:
Michael C. Bassik, Andrew C. Yang, David Gate, Jian Luo, Michael S. Haney, Liana Bonanno, Tal Iram, Madeleine K D Scott, Davis P. Lee, David W. Morgens, Lulin Li, John V. Pluvinage, Benjamin A. H. Smith, Carolyn R. Bertozzi, Jerry Sun, Tony Wyss-Coray, Steven R. Shuken, Purvesh Khatri
Publikováno v:
Nature
Microglia maintain homeostasis in the central nervous system through phagocytic clearance of protein aggregates and cellular debris. This function deteriorates during ageing and neurodegenerative disease, concomitant with cognitive decline. However,
Autor:
Madeleine K D, Scott, Maneesha, Limaye, Steven, Schaffert, Robert, West, Michael G, Ozawa, Pauline, Chu, Viswam S, Nair, Albert C, Koong, Purvesh, Khatri
Publikováno v:
Pac Symp Biocomput
An early biomarker would transform our ability to screen and treat patients with cancer. The large amount of multi-scale molecular data in public repositories from various cancers provide unprecedented opportunities to find such a biomarker. However,
Autor:
Sophia Mahoney, Madeleine K D Scott, John J. Tanner, Ashley Loureiro, Gary K. Scott, Lisa M. Ellerby, Christopher C. Benz, Alejandro Lopez-Ramirez
Publikováno v:
Amino Acids
Proline dehydrogenase (PRODH) is a mitochondrial inner membrane flavoprotein critical for cancer cell survival under stress conditions and newly recognized as a potential target for cancer drug development. Reversible (competitive) and irreversible (