Výsledky vyhledávání - "Madeleine H. Li"

MMP-13 selective α-sulfone hydroxamates: a survey of P1' heterocyclic amide isosteres

Autor: Karl J. Mathis, Madeleine H. Li, Alan M. Easton, Clara I. Villamil, Barta Thomas E, Grace E. Munie, Daniel P. Becker, Jennifer M. Williams, James R. Kiefer, Louis J. Bedell, Rico Joseph G, Susan L. Hockerman

Publikováno v: Bioorganicmedicinal chemistry letters. 21(10)

Seeking compounds preferentially potent and selective for MMP-13, we reported in the preceding Letter on a series of hydroxamic acids with a flexible benzamide tail groups.(1a) Here, we replace the amide moiety with non-hydrolyzable heterocycles in a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78ffe35bcbf17ed83e09ea89e7da6550
https://pubmed.ncbi.nlm.nih.gov/21507637

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Orally active MMP-1 sparing α-tetrahydropyranyl and α-piperidinyl sulfone matrix metalloproteinase (MMP) inhibitors with efficacy in cancer, arthritis, and cardiovascular disease

Publikováno v: Journal of medicinal chemistry. 53(18)

α-Sulfone-α-piperidine and α-tetrahydropyranyl hydroxamates were explored that are potent inhibitors of MMP's-2, -9, and -13 that spare MMP-1, with oral efficacy in inhibiting tumor growth in mice and left-ventricular hypertrophy in rats and in th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9685357a0ce79c92aebc66064d268699
https://pubmed.ncbi.nlm.nih.gov/20726512

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Synthesis and structure-activity relationships of beta- and alpha-piperidine sulfone hydroxamic acid matrix metalloproteinase inhibitors with oral antitumor efficacy

Autor: Chris P. Carron, Craig Swearingen, Louis J. Bedell, John N. Freskos, Getman Daniel P, Clara I. Villamil, Grace E. Munie, Pramod P. Mehta, Boehm Terri L, Barta Thomas E, Madeleine H. Li, Daniel P. Becker, Susan L. Hockerman, Susan C. Howard, Heintz Robert M, Joseph J. McDonald, Chris L. Funckes-Shippy, Decrescenzo Gary A

Publikováno v: Journal of medicinal chemistry. 48(21)

alpha-Piperidine-beta-sulfone hydroxamate derivatives were explored that are potent for matrix metalloproteinases (MMP)-2, -9, and -13 and are sparing of MMP-1. The investigation of the beta-sulfones subsequently led to the discovery of hitherto unkn

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0539500154a05a00e3a097afebbcc7a1
https://pubmed.ncbi.nlm.nih.gov/16220987

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Akademický článek

Orally Active MMP-1 Sparing Î±-Tetrahydropyranyl and Î±-Piperidinyl Sulfone Matrix Metalloproteinase (MMP) Inhibitors with Efficacy in Cancer, Arthritis, and Cardiovascular Disease.

Publikováno v: Journal of Medicinal Chemistry; Sep2010, Vol. 53 Issue 18, p6653-6680, 28p

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