Zobrazeno 1 - 10
of 109
pro vyhledávání: '"Madeleine E. Lemieux"'
Autor:
Madeleine E. Lemieux, Xavier T. Reveles, Jennifer Rebeles, Lydia H. Bederka, Patricia R. Araujo, Jamila R. Sanchez, Marcia Grayson, Shao-Chiang Lai, Louis R. DePalo, Sheila A. Habib, David G. Hill, Kathleen Lopez, Lara Patriquin, Robert Sussman, Roby P. Joyce, Vivienne I. Rebel
Publikováno v:
Respiratory Research, Vol 24, Iss 1, Pp 1-16 (2023)
Abstract Background Low-dose spiral computed tomography (LDCT) may not lead to a clear treatment path when small to intermediate-sized lung nodules are identified. We have combined flow cytometry and machine learning to develop a sputum-based test (C
Externí odkaz:
https://doaj.org/article/d3f1133571fa41c98dbfa1a17abe84ab
Autor:
Wesley C. Warren, Tyler E. Boggs, Richard Borowsky, Brian M. Carlson, Estephany Ferrufino, Joshua B. Gross, LaDeana Hillier, Zhilian Hu, Alex C. Keene, Alexander Kenzior, Johanna E. Kowalko, Chad Tomlinson, Milinn Kremitzki, Madeleine E. Lemieux, Tina Graves-Lindsay, Suzanne E. McGaugh, Jeffrey T. Miller, Mathilda T. M. Mommersteeg, Rachel L. Moran, Robert Peuß, Edward S. Rice, Misty R. Riddle, Itzel Sifuentes-Romero, Bethany A. Stanhope, Clifford J. Tabin, Sunishka Thakur, Yoshiyuki Yamamoto, Nicolas Rohner
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Mexican Tetra cavefish have long been of interest in understanding adaptation to severe environmental change. Here the authors present a chromosome-level genome for the proxy-ancestral surface fish, and use CRISPR gene-editing to show the role of the
Externí odkaz:
https://doaj.org/article/e0b3331ea2974ca4af008dc49760b084
Autor:
Filipa C. Simões, Thomas J. Cahill, Amy Kenyon, Daria Gavriouchkina, Joaquim M. Vieira, Xin Sun, Daniela Pezzolla, Christophe Ravaud, Eva Masmanian, Michael Weinberger, Sarah Mayes, Madeleine E. Lemieux, Damien N. Barnette, Mala Gunadasa-Rohling, Ruth M. Williams, David R. Greaves, Le A. Trinh, Scott E. Fraser, Sarah L. Dallas, Robin P. Choudhury, Tatjana Sauka-Spengler, Paul R. Riley
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Macrophages mediate the fibrotic response after a heart attack by extracellular matrix turnover and cardiac fibroblasts activation. Here the authors identify an evolutionarily-conserved function of macrophages that contributes directly to the forming
Externí odkaz:
https://doaj.org/article/edf55153a7b34a528c084339f4ceeac3
Autor:
Helen G. Potts, Madeleine E. Lemieux, Edward S. Rice, Wesley Warren, Robin P. Choudhury, Mathilda T. M. Mommersteeg
Publikováno v:
Cells, Vol 11, Iss 4, p 608 (2022)
Advances in sequencing and assembly technology have led to the creation of genome assemblies for a wide variety of non-model organisms. The rapid production and proliferation of updated, novel assembly versions can create vexing problems for research
Externí odkaz:
https://doaj.org/article/158994f1a5ca40c5ac1716139f778947
Autor:
Ioana I. Nitulescu, Sara C. Meyer, Qiang Jeremy Wen, John D. Crispino, Madeleine E. Lemieux, Ross L. Levine, Henry E. Pelish, Matthew D. Shair
Publikováno v:
EBioMedicine, Vol 26, Iss C, Pp 112-125 (2017)
Constitutive JAK-STAT signaling drives the proliferation of most myeloproliferative neoplasms (MPN) and a subset of acute myeloid leukemia (AML), but persistence emerges with chronic exposure to JAK inhibitors. MPN and post-MPN AML are dependent on t
Externí odkaz:
https://doaj.org/article/fed4a5b27cf64d74986dc79cb947a5fb
Autor:
Tomasz Sewastianik, Meng Jiang, Kumar Sukhdeo, Sanjay S. Patel, Kathryn Roberts, Yue Kang, Ahmad Alduaij, Peter S. Dennis, Brian Lawney, Ruiyang Liu, Zeyuan Song, Jessie Xiong, Yunyu Zhang, Madeleine E. Lemieux, Geraldine S. Pinkus, Jeremy N. Rich, David M. Weinstock, Charles G. Mullighan, Norman E. Sharpless, Ruben D. Carrasco
Publikováno v:
Blood Advances, Vol 1, Iss 25, Pp 2361-2374 (2017)
Abstract: Despite recent advances in treatment, human precursor B-cell acute lymphoblastic leukemia (B-ALL) remains a challenging clinical entity. Recent genome-wide studies have uncovered frequent genetic alterations involving RAS pathway mutations
Externí odkaz:
https://doaj.org/article/0bffaf03598f493abbda75d7dff75772
Autor:
William T. Stockdale, Madeleine E. Lemieux, Abigail C. Killen, Juanjuan Zhao, Zhilian Hu, Joey Riepsaame, Noémie Hamilton, Tetsuhiro Kudoh, Paul R. Riley, Ronny van Aerle, Yoshiyuki Yamamoto, Mathilda T.M. Mommersteeg
Publikováno v:
Cell Reports, Vol 25, Iss 8, Pp 1997-2007.e7 (2018)
Summary: Although Astyanax mexicanus surface fish regenerate their hearts after injury, their Pachón cave-dwelling counterparts cannot and, instead, form a permanent fibrotic scar, similar to the human heart. Myocardial proliferation peaks at simila
Externí odkaz:
https://doaj.org/article/50b4dde1883046998c94a2044fce2a44
Autor:
Tatiana V. Kolesnikova, Alexander R. Kazarov, Madeleine E. Lemieux, Marc A. Lafleur, Santosh Kesari, Andrew L. Kung, Martin E. Hemler
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 11, Iss 1, Pp 77-86 (2009)
EWI-2, a cell surface IgSF protein, is highly expressed in normal human brain but is considerably diminished in glioblastoma tumors and cell lines. Moreover, loss of EWI-2 expression correlated with a shorter survival time in human glioma patients, s
Externí odkaz:
https://doaj.org/article/f81b28a80d654531bfba39a55afd3d4e
Autor:
Marcello Rubino, Joshua G. Travers, Alaina L. Headrick, Blake T. Enyart, Madeleine E. Lemieux, Maria A. Cavasin, Jessica A. Schwisow, Elizabeth J. Hardy, Keenan J. Kaltenbacher, Marina B. Felisbino, Eric Jonas, Amrut V. Ambardekar, Michael R. Bristow, Keith A. Koch, Timothy A. McKinsey
Publikováno v:
Circulation Research. 132:10-29
Background: Organ fibrosis due to excessive production of extracellular matrix by resident fibroblasts is estimated to contribute to >45% of deaths in the Western world, including those due to cardiovascular diseases such as heart failure. Here, we s
Autor:
Christopher A. French, Mitzi I. Kuroda, Philip A. Cole, Madeleine E. Lemieux, Prafulla C. Gokhale, Kristen L. Jones, David A. Scott, Yeying Huang, Nhi M. Luong, Tatiana M. Knox, Ivona Filic, Zhipeng A. Wang, Artyom A. Alekseyenko, Hitoshi Shiota
NUT carcinoma (NC), characterized most commonly by the BRD4-NUTM1 fusion, is a rare, aggressive variant of squamous carcinoma with no effective treatment. BRD4-NUT drives growth and maintains the poorly differentiated state of NC by activating pro-gr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1830c1380d8fc853fdbe60b26eeb0400
https://doi.org/10.1158/1541-7786.c.6544953.v1
https://doi.org/10.1158/1541-7786.c.6544953.v1