Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Madeleine E Kieffer"'
Publikováno v:
Expert opinion on therapeutic patents. 30(11)
Toll-like receptors 7 and 8 (TLR7 and TLR8) are endosomal immune receptors that initiate an innate immune response and can facilitate activation of the adaptive immune system. Both preclinical and clinical studies have shown the downstream inflammato
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72dfb347da58879c0cf265ac554d59fa
https://pubmed.ncbi.nlm.nih.gov/33052748
https://pubmed.ncbi.nlm.nih.gov/33052748
Publikováno v:
Organic Letters. 18:4750-4753
A mild and general protocol for the Pd(0)-catalyzed heteroannulation of o-bromoanilines and alkynes is described. Application of a Pd(0)/P((t)Bu)3 catalyst system enables the efficient coupling of o-bromoanilines at 60 °C, mitigating deleterious sid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acd7b2f8630ba3cd778f7c78aefa704c
https://doi.org/10.1021/acs.orglett.6b02477
https://doi.org/10.1021/acs.orglett.6b02477
Publikováno v:
Asymmetric Dearomatization Reactions
This chapter covers recent advances in catalytic, asymmetric dearomatization reactions that proceed by cycloaddition. Despite its high stability, which renders it challenging to dearomatize via cycloaddition, Buchner and coworkers discovered the cycl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3608001412c647323ccddb1e0fa31fdf
https://doi.org/10.1002/9783527698479.ch7
https://doi.org/10.1002/9783527698479.ch7
Publikováno v:
Journal of the American Chemical Society. 134:5131-5137
The tandem Friedel-Crafts conjugate addition/asymmetric protonation reaction between 2-substituted indoles and methyl 2-acetamidoacrylate is reported. The reaction is catalyzed by (R)-3,3'-dibromo-BINOL in the presence of stoichiometric SnCl(4), and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acd8d48f314c933b04a1eaa9c8e48240
https://doi.org/10.1021/ja209390d
https://doi.org/10.1021/ja209390d
Publikováno v:
Biochemistry and Molecular Biology Education. 38:216-223
As computational modeling plays an increasingly central role in biochemical research, it is important to provide students with exposure to common modeling methods in their undergraduate curriculum. This article describes a series of computer labs des
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fefd81b1bb91a3853936fde3ac7f2c0e
https://doi.org/10.1002/bmb.20396
https://doi.org/10.1002/bmb.20396
A copper-catalyzed arylation of tryptophan derivatives is reported. The reaction proceeds with high site- and diastereoselectivity to provide aryl pyrroloindoline products in one step from simple starting materials. The utility of this transformation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef412d529ee48247223c8acac4a0117b
https://europepmc.org/articles/PMC3662218/
https://europepmc.org/articles/PMC3662218/
Publikováno v:
ChemInform. 44
An operationally simple, copper-catalyzed arylation of N-tosyltryptamines provides direct access to C3-aryl pyrroloindolines.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b029ec850c2cac740c0fa2d0d8c92add
https://doi.org/10.1002/chin.201313095
https://doi.org/10.1002/chin.201313095
Publikováno v:
ChemInform. 43
The reaction of substituted indoles with methyl 2-acetamidoacrylate (II) catalyzed by (R)-3,3′-dibromo-BINOL and SnCl4, leads to synthetic tryptophan derivatives in good yields and high enantioselectivities.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::57b79b5eecfdec0881c0dccd9038b905
https://doi.org/10.1002/chin.201233207
https://doi.org/10.1002/chin.201233207
Autor:
Philip A. Woods, Louis C. Morrill, Caroline Joannesse, Herbert Mayr, Madeleine E. Kieffer, Tobias A. Nigst, Craig P. Johnston, Ryan A. Bragg, Andrew D. Smith, Tomas Lebl, Douglas Philp
Publikováno v:
Chemistry (Weinheim an der Bergstrasse, Germany). 18(8)
The structural motif within a series of tetrahydropyrimidine-based isothioureas necessary for generating high asymmetric induction in the asymmetric Steglich rearrangement of oxazolyl carbonates is fully explored, with crossover and dynamic (19)F NMR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f9d5f5d9eccf0dbd15c1b571c6ee97a
https://pubmed.ncbi.nlm.nih.gov/22262624
https://pubmed.ncbi.nlm.nih.gov/22262624
Publikováno v:
Chemical Science. 3:3170
An operationally simple, copper-catalyzed arylation of N-tosyltryptamines provides direct access to C3-aryl pyrroloindolines. A range of electron-donating and electron-withdrawing substituents is tolerated on both the indole backbone and the aryl ele
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1785c21ab06bfc694f51867757b09b27
https://doi.org/10.1039/c2sc20914d
https://doi.org/10.1039/c2sc20914d