Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Madeleine C Klein"'
Publikováno v:
eLife, Vol 7 (2018)
Pain behaviors in a Fabry mouse model are associated with the accumulation of a fat molecule that disrupts sodium ion channels in small fiber neurons.
Externí odkaz:
https://doaj.org/article/d5576465d7bf4a99a96f8ab902437b4c
Autor:
Elisabeth S. Butz, Mika O. Ruonala, Uma Chandrachud, Anton Petcherski, Stephen J. Haggarty, Surya A. Reis, Wen-Ning Zhao, Madeleine C Klein, Susan L. Cotman
Publikováno v:
Cells
Volume 8
Issue 12
Volume 8
Issue 12
Alterations in the autophagosomal&ndash
lysosomal pathway are a major pathophysiological feature of CLN3 disease, which is the most common form of childhood-onset neurodegeneration. Accumulating autofluorescent lysosomal storage material in CLN3
lysosomal pathway are a major pathophysiological feature of CLN3 disease, which is the most common form of childhood-onset neurodegeneration. Accumulating autofluorescent lysosomal storage material in CLN3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6748895c2beba6f340e22eb02091dd8f
http://publikationen.ub.uni-frankfurt.de/files/51693/container.zip
http://publikationen.ub.uni-frankfurt.de/files/51693/container.zip
Autor:
Stephanie Norton, Uma Chandrachud, Anton Petcherski, Sasja Heetveld, Stephen J. Haggarty, Pavlina Wolf, Hye Jin Oh, Susan L. Cotman, Madeleine C Klein, Alexandra M. Simas, Wen-Ning Zhao, Mathew W. Walker, Emyr Lloyd-Evans
Publikováno v:
Journal of Biological Chemistry. 290:14361-14380
Abnormal accumulation of undigested macromolecules, often disease-specific, is a major feature of lysosomal and neurodegenerative disease and is frequently attributed to defective autophagy. The mechanistic underpinnings of the autophagy defects are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ace6ca77dfebd7e3e4eacc54e024612c
https://doi.org/10.1074/jbc.m114.621706
https://doi.org/10.1074/jbc.m114.621706