Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Madeleine Böckers"'
Publikováno v:
Journal of Advanced Research, Vol 16, Iss , Pp 145-156 (2019)
Polo-like kinase 1 (PLK1), a member of the Polo-like kinase family, plays an important regulatory role in mitosis and cell cycle progression. PLK1 overexpression is correlated with tumourigenesis and poor prognosis in cancer patients. Therefore, the
Externí odkaz:
https://doaj.org/article/e992528721764425979602b0ba4ad0a3
Publikováno v:
Journal of Advanced Research, Vol 16, Iss, Pp 145-156 (2019)
Journal of Advanced Research
Journal of Advanced Research
Graphical abstract
Highlights • We were able to identify a novel anticancer molecule that targets PLK1. • The compound shows good activity in leukaemia-sensitive and -resistant cells. • Compound (1) induces mitotic arrest and interferes wi
Highlights • We were able to identify a novel anticancer molecule that targets PLK1. • The compound shows good activity in leukaemia-sensitive and -resistant cells. • Compound (1) induces mitotic arrest and interferes wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::498b4b6cf155d7b1326b3097bbd033cc
http://www.sciencedirect.com/science/article/pii/S2090123218301073
http://www.sciencedirect.com/science/article/pii/S2090123218301073
Publikováno v:
World Academy of Sciences Journal. 3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::75f2b1b447209ae9218d6ae7bd1c2a42
https://doi.org/10.3892/wasj.2021.92
https://doi.org/10.3892/wasj.2021.92
Autor:
Madeleine Böckers, Thomas Efferth, Sabine M. Klauck, Mona Dawood, Matthias M. Weber, Ge Yan, Christian Fottner
Publikováno v:
Phytomedicine : international journal of phytotherapy and phytopharmacology. 79
Background The paucity of effective treatment in neuroendocrine tumors (NETs) encouraged us to investigate the therapeutic value of artesunate (ART) promised by its inhibitory effect against various tumors and broad safety profile. Methods We evaluat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a8a4134db1f8541cd814f61166a1404
https://pubmed.ncbi.nlm.nih.gov/32957040
https://pubmed.ncbi.nlm.nih.gov/32957040
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 129, Iss, Pp 110454-(2020)
HDAC6 is a crucial epigenetic modifier that plays a vital role in tumor progression and carcinogenesis due to its multiple biological functions. It is a unique member of class-II HDAC enzymes. It possesses two catalytic domains, which function indepe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::416fc82108211c721449e5eb72ae1d44
https://pubmed.ncbi.nlm.nih.gov/32768947
https://pubmed.ncbi.nlm.nih.gov/32768947
Publikováno v:
Toxicology and applied pharmacology. 396
Currently, the environmental impact of ubiquitous plastic debris triggered quite some public attention. However, the global impact of microplastic on human health is by and large either unknown or neglected. By looking at the underlying biochemical m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::962320ca3066ba5d66ce52fdb50a33be
https://pubmed.ncbi.nlm.nih.gov/32251684
https://pubmed.ncbi.nlm.nih.gov/32251684
Autor:
Edmond Fleischer, Anette Klinger, Thomas Efferth, Maitane Asensio, Sara Abdelfatah, Madeleine Böckers, Onat Kadioglu
Publikováno v:
Phytomedicine. 86:153196
Background A major problem of cancer treatment is the development of multidrug resistance (MDR) to chemotherapy. MDR is caused by different mechanisms such as the expression of the ABC-transporters P-glycoprotein (P-gp, MDR1, ABCB1) and breast cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13df3a2ac9cfcc9fb5b17dd679ead21b
https://doi.org/10.1016/j.phymed.2020.153196
https://doi.org/10.1016/j.phymed.2020.153196
Publikováno v:
Toxicology and Applied Pharmacology. 399:115030
Plasticizers released from microplastic are increasingly viewed with concern. While adverse health effects induced by bisphenol A and its analogues on marine animals are well documented in the literature, the endocrine potential of bisphenolic compou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aaef12f4125ee56d1e39ba456f2c8c3c
https://doi.org/10.1016/j.taap.2020.115030
https://doi.org/10.1016/j.taap.2020.115030
Publikováno v:
Toxicology and Applied Pharmacology. 395:114977
Plastic in the ocean degrades to microplastic, thereby enhancing the leaching of incorporated plasticizers due to the increased particle surface. The uptake of microplastic-derived plasticizers by marine animals and the subsequent entry in the food c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e58afc038c90e0bcf1a2f6531de970c
https://doi.org/10.1016/j.taap.2020.114977
https://doi.org/10.1016/j.taap.2020.114977
Autor:
Zahir Yasin, Lígia Salgueiro, Olipa D Ngassapa, Sara Abdelfatah, Mita Banerjee, Marta R. Romero, Edna Ooko, Hesham R. El-Seedi, Dominic O. Ochwang’i, Markus Horneber, Sami Hamdoun, Madeleine Böckers, Jacob O. Midiwo, Hiroshi Nakagawa, Chunlan Hong, Ge Yan, Henry Johannes Greten, Armelle T. Mbaveng, Ömür L. Demirezer, Mohamed E.M. Saeed, Janine Naß, Ean-Jeong Seo, Victor Kuete, Nadire Özenver, Jose J.G. Marin, M. S. Abu-Darwish, Monika Efferth, Vanderlan da Silva Bolzani, Leonida K. Omosa, Elfatih M. Saeed, Sami A. Khalid, Onat Kadioglu, Salah Daak, Mona Dawood, Hassan E. Khalid, Nuha Mahmoud, Thomas Efferth, Paramasivan Poornima, Dipita Bhakta-Guha, Nicolas Fischer, Norbert W. Paul
Publikováno v:
Phytomedicine : international journal of phytotherapy and phytopharmacology. 53
Background Practices of biopiracy to use genetic resources and indigenous knowledge by Western companies without benefit-sharing of those, who generated the traditional knowledge, can be understood as form of neocolonialism. Hypothesis The One-World
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::598bb5f5f09b642e366a55ab356939a7
https://pubmed.ncbi.nlm.nih.gov/30190231
https://pubmed.ncbi.nlm.nih.gov/30190231