Výsledky vyhledávání - "Madeleine A. Kane"

How Should Clinicians Respond to Race-Based Algorithms as Sources of Iatrogenic Harm?

Autor: Madeleine Maddy, Kane, Rachel, Bervell, Angela Y, Zhang, Jennifer, Tsai

Publikováno v: AMA journal of ethics. 24(8)

Some clinical algorithms use race as an epidemiological shorthand to "correct" for health determinants that are clinically influential but also variable because they are historical, social, cultural, or economic in origin. Such "correction factors" a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::cf62122c97c7c6b4524edee8ece49aef
https://pubmed.ncbi.nlm.nih.gov/35976927

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A phase II study of the orally administered negative enantiomer of gossypol (AT-101), a BH3 mimetic, in patients with advanced adrenal cortical carcinoma

Autor: Charles Erlichman, David R. Gandara, Hao Xie, Michael E. Menefee, Madeleine A. Kane, Alex A. Adjei, David I. Quinn, Jun Yin, Diane Reidy-Lagunes, Manisha H. Shah, Keith C. Bible

Publikováno v: Invest New Drugs

BACKGROUND: Adrenal cortical carcinoma (ACC) is a rare cancer with treatment options of limited efficacy, and poor prognosis if metastatic. AT-101 is a more potent inhibitor of B cell lymphoma 2 family apoptosis-related proteins than its racemic form

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9aef795f181376446ebbbe1daa8a5ca
https://doi.org/10.1007/s10637-019-00797-1

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Impact of Radiation Dose on Postoperative Complications in Esophageal and Gastroesophageal Junction Cancers

Publikováno v: Frontiers in Oncology
Frontiers in Oncology, Vol 11 (2021)

Introduction: The impact of radiation prescription dose on postoperative complications during standard of care trimodality therapy for operable stage II-III esophageal and gastroesophageal junction cancers has not been established.Methods: We retrosp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91d764f9bb3fd690280ec60509079469
https://doi.org/10.3389/fonc.2021.614640

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An International Phase 2 Study of Pazopanib in Progressive and Metastatic Thyroglobulin Antibody Negative Radioactive Iodine Refractory Differentiated Thyroid Cancer

Publikováno v: Thyroid

Introduction: Multikinase inhibitors have clinical activity in radioactive iodine refractory (RAIR) differentiated thyroid cancers (DTCs) but are not curative; optimal management and salvage therapies remain unclear. This study assessed clinical effe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::942d7cd4430789c5c4a9d69fe923e627
https://pubmed.ncbi.nlm.nih.gov/32538690

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Final Report of a Phase I Trial of Olaparib with Cetuximab and Radiation for Heavy Smoker Patients with Locally Advanced Head and Neck Cancer

Autor: Timothy V. Waxweiler, Aik Choo Tan, Patrick J. Blatchford, Xiao-Jing Wang, Dara L. Aisner, Christian D. Young, Antonio Jimeno, Carrie Marshall, David Raben, Ayman Oweida, Krishna Reddy, Daniel W. Bowles, Hilary Somerset, Sana D. Karam, Alicia M. DeLouize, Kurtis D. Davies, Madeleine A. Kane

Publikováno v: Clinical Cancer Research. 24:4949-4959

Purpose: Our goal was to evaluate the safety and toxicity of combining a PARP inhibitor, olaparib, with cetuximab and fractionated intensity-modulated radiotherapy for patients with locally advanced head and neck cancer and heavy smoking histories. P

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8af52cc22fafdf1735f058eb134d6bd
https://doi.org/10.1158/1078-0432.ccr-18-0467

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Treatment of advanced thyroid cancer with axitinib: Phase 2 study with pharmacokinetic/pharmacodynamic and quality-of-life assessments

Autor: Connie Chen, Antonella Ingrosso, Laura Agate, Laura D. Locati, Shukui Qin, Madeleine A. Kane, Ezra E.W. Cohen, Andrée Boucher, Paul Bycott, Barbara Jarzab, Lori J. Wirth, Yazdi K. Pithavala, Lisa Licitra, Sinil Kim, Sai-Hong Ignatius Ou

Publikováno v: Cancer. 120:2694-2703

BACKGROUND In a previous phase 2 trial, axitinib was active and well tolerated in patients with advanced thyroid cancer. In this second phase 2 trial, the efficacy and safety of axitinib were evaluated further in this population, and pharmacokinetic/

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0de86b4ca2072364510c58913d219ce5
https://doi.org/10.1002/cncr.28766

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Evolution of Skid Resistance of Different Materials for Metro Rolling Tracks

Autor: C. Khelifi, M. Adenot Meyer, Madeleine A. Kane

Publikováno v: DEStech Transactions on Environment, Energy and Earth Science.

This paper investigates the evolution of skid resistance against traffic of different tracks materials for rubber-tired metro. Experimental analysis based on the friction analysis of different track specimens at different polishing states is done. Th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e982fbf16bb6a230b9684342019f9a94
https://doi.org/10.12783/dteees/seeie2016/4684

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Phase I trial of vandetanib in combination with gemcitabine and capecitabine in patients with advanced solid tumors with an expanded cohort in pancreatic and biliary cancers

Autor: Christopher H. Lieu, Todd M. Pitts, Cindy L. O’byrant, Jennifer L. Spratlin, Stephen Leong, Sarah Eppers, Sujatha Nallapreddy, S. Gail Eckhardt, Elizabeth R. Kessler, Madeleine A. Kane, Erica L. Bradshaw-Pierce, Wells A. Messersmith, Colin D. Weekes, Elizabeth Freas

Background Vandetanib is a multitargeted tyrosine kinase inhibitor that affects vascular endothelial growth factor receptor (VEGF), epidermal growth factor (EGF), and rearranged during transfection (RET) mediated receptors which are important for gro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffe4e0d5baa3ed421cbdcf0a4384b59c
https://europepmc.org/articles/PMC4788525/

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Approach to the Thyroid Cancer Patient with Extracervical Metastases

Autor: Madeleine A. Kane, Bryan R. Haugen

Publikováno v: The Journal of Clinical Endocrinology & Metabolism. 95:987-993

Patients with distant, or extracervical, metastases from differentiated thyroid cancer require multimodality diagnostic, therapeutic, and monitoring approaches. Whereas cure is the initial goal, especially in those with small, radioiodine-avid pulmon

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99f12e5c622e085a13894759d9a238b8
https://doi.org/10.1210/jc.2009-2305

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