Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Madeleine, Wakeling"'
Autor:
Simon Mead, Azadeh Khalili-Shirazi, Caroline Potter, Tzehow Mok, Akin Nihat, Harpreet Hyare, Stephanie Canning, Christian Schmidt, Tracy Campbell, Lee Darwent, Nicola Muirhead, Nicolette Ebsworth, Patrick Hextall, Madeleine Wakeling, Jacqueline Linehan, Vincenzo Libri, Bryan Williams, Zane Jaunmuktane, Sebastian Brandner, Peter Rudge, John Collinge
Publikováno v:
The Lancet Neurology. 21:342-354
Human prion diseases, including Creutzfeldt-Jakob disease (CJD), are rapidly progressive, invariably fatal neurodegenerative conditions with no effective therapies. Their pathogenesis involves the obligate recruitment of cellular prion protein (PrPWe
Autor:
Igor, Klyubin, Andrew J, Nicoll, Azadeh, Khalili-Shirazi, Michael, Farmer, Stephanie, Canning, Alexandra, Mably, Jacqueline, Linehan, Alexander, Brown, Madeleine, Wakeling, Sebastian, Brandner, Dominic M, Walsh, Michael J, Rowan, John, Collinge
Publikováno v:
The Journal of neuroscience : the official journal of the Society for Neuroscience. 34(18)
Alzheimer's disease (AD) is associated with pathological assembly states of amyloid-β protein (Aβ). Aβ-related synaptotoxicity can be blocked by anti-prion protein (PrP) antibodies, potentially allowing therapeutic targeting of this aspect of AD n
Autor:
Emma Turnbull, Yvonne McGrath, Madeleine Wakeling, Suzanne Thomas, Philip Reay, Mei Yi-Sun, Binlei Liu, Justin John, R. S. Coffin
Publikováno v:
Molecular Therapy. 9:S102
Dendritic cell (DC)-based vaccines are promising for cancer treatment. However, there are significant problems of efficient antigen loading and practicality of current approaches. Herpes simplex virus (HSV), unlike most viruses, infects DC very effic